EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

Detalhes bibliográficos
Autor(a) principal: Lombardi, Raúl
Data de Publicação: 2019
Outros Autores: Ferreiro, Alejandro, Granado, Rolando Claure-Del, Burdmann, Emmanuel A., Rosa-Diez, Guillermo, Yu, Luis, Younes-Ibrahim, Mauricio, Carlino, Cristina, Chávez-Iñiguez, Jonathan S., Pereira, Mariana B., Varela, Carlos F., Zamoner, Welder [UNESP], Janiques, Diego, Lecueder, Soledad, Cerrón-Millán, Víctor, Cueto-Manzano, Alfonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1371/journal.pone.0224655
http://hdl.handle.net/11449/201084
Resumo: Introduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model. Results Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50–74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%. Conclusions AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.
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spelling EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin AmericaIntroduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model. Results Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50–74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%. Conclusions AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.Dept. of Nephrology School of Medicine Universidad de la RepúblicaDivision of Nephrology Hospital Obrero #2 - C.N.S. Universidad Mayor de San Simon School of MedicineLIM 12 Division of Nephrology University of Sao Paulo Medical SchoolDept. of Nehrology Hospital ItalianoDept. of Internal Medicine University of Rio de JaneiroHospital ProvincialHospital Civil de Guadalajara Centro Universitario de Ciencias de la SaludNephrology Division Hospital do Servidor Público Estadual Universidade Nove de JulhoBotucatu School of Medicine São Paulo State University-UNESPClinica Renalle Pontifícia Universidade Católica PetrópolisSanatorio Casa de GaliciaHospital Nacional Daniel Alcides Carrión Dept. de Medicina Servicio de NefrologíaMedical Research Unit of Renal Diseases Hospital de Especialidades CMNO IMSSBotucatu School of Medicine São Paulo State University-UNESPUniversidad de la RepúblicaUniversidad Mayor de San Simon School of MedicineUniversidade de São Paulo (USP)Hospital ItalianoUniversity of Rio de JaneiroHospital ProvincialCentro Universitario de Ciencias de la SaludUniversidade Nove de JulhoUniversidade Estadual Paulista (Unesp)PetrópolisSanatorio Casa de GaliciaServicio de NefrologíaIMSSLombardi, RaúlFerreiro, AlejandroGranado, Rolando Claure-DelBurdmann, Emmanuel A.Rosa-Diez, GuillermoYu, LuisYounes-Ibrahim, MauricioCarlino, CristinaChávez-Iñiguez, Jonathan S.Pereira, Mariana B.Varela, Carlos F.Zamoner, Welder [UNESP]Janiques, DiegoLecueder, SoledadCerrón-Millán, VíctorCueto-Manzano, Alfonso2020-12-12T02:23:43Z2020-12-12T02:23:43Z2019-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0224655PLoS ONE, v. 14, n. 11, 2019.1932-6203http://hdl.handle.net/11449/20108410.1371/journal.pone.02246552-s2.0-85075071489Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2024-08-14T17:23:32Zoai:repositorio.unesp.br:11449/201084Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
title EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
spellingShingle EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
Lombardi, Raúl
title_short EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
title_full EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
title_fullStr EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
title_full_unstemmed EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
title_sort EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
author Lombardi, Raúl
author_facet Lombardi, Raúl
Ferreiro, Alejandro
Granado, Rolando Claure-Del
Burdmann, Emmanuel A.
Rosa-Diez, Guillermo
Yu, Luis
Younes-Ibrahim, Mauricio
Carlino, Cristina
Chávez-Iñiguez, Jonathan S.
Pereira, Mariana B.
Varela, Carlos F.
Zamoner, Welder [UNESP]
Janiques, Diego
Lecueder, Soledad
Cerrón-Millán, Víctor
Cueto-Manzano, Alfonso
author_role author
author2 Ferreiro, Alejandro
Granado, Rolando Claure-Del
Burdmann, Emmanuel A.
Rosa-Diez, Guillermo
Yu, Luis
Younes-Ibrahim, Mauricio
Carlino, Cristina
Chávez-Iñiguez, Jonathan S.
Pereira, Mariana B.
Varela, Carlos F.
Zamoner, Welder [UNESP]
Janiques, Diego
Lecueder, Soledad
Cerrón-Millán, Víctor
Cueto-Manzano, Alfonso
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de la República
Universidad Mayor de San Simon School of Medicine
Universidade de São Paulo (USP)
Hospital Italiano
University of Rio de Janeiro
Hospital Provincial
Centro Universitario de Ciencias de la Salud
Universidade Nove de Julho
Universidade Estadual Paulista (Unesp)
Petrópolis
Sanatorio Casa de Galicia
Servicio de Nefrología
IMSS
dc.contributor.author.fl_str_mv Lombardi, Raúl
Ferreiro, Alejandro
Granado, Rolando Claure-Del
Burdmann, Emmanuel A.
Rosa-Diez, Guillermo
Yu, Luis
Younes-Ibrahim, Mauricio
Carlino, Cristina
Chávez-Iñiguez, Jonathan S.
Pereira, Mariana B.
Varela, Carlos F.
Zamoner, Welder [UNESP]
Janiques, Diego
Lecueder, Soledad
Cerrón-Millán, Víctor
Cueto-Manzano, Alfonso
description Introduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model. Results Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50–74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%. Conclusions AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-01
2020-12-12T02:23:43Z
2020-12-12T02:23:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1371/journal.pone.0224655
PLoS ONE, v. 14, n. 11, 2019.
1932-6203
http://hdl.handle.net/11449/201084
10.1371/journal.pone.0224655
2-s2.0-85075071489
url http://dx.doi.org/10.1371/journal.pone.0224655
http://hdl.handle.net/11449/201084
identifier_str_mv PLoS ONE, v. 14, n. 11, 2019.
1932-6203
10.1371/journal.pone.0224655
2-s2.0-85075071489
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE
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dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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