Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties

Detalhes bibliográficos
Autor(a) principal: de Lima Fontes, Marina
Data de Publicação: 2018
Outros Autores: Meneguin, Andréia Bagliotti, Tercjak, Agnieszka, Gutierrez, Junkal, Cury, Beatriz Stringhetti Ferreira [UNESP], dos Santos, Aline Martins [UNESP], Ribeiro, Sidney J.L. [UNESP], Barud, Hernane S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.carbpol.2017.09.061
http://hdl.handle.net/11449/175271
Resumo: Bacterial cellulose/carboxymethylcelullose (BC/CMC) biocomposites with different DS-CMC (DS from 0.7 to 1.2) were developed in order to evaluate their impact as a drug delivery system. Biocomposites were loaded with methotrexate (MTX) as an alternative for the topical treatment of psoriasis. Scanning electron microscopy and atomic force microscopy showed that the CMC coated the cellulose nanofibers, leading to the decrease of the elastic modulus as the DS of CMC increased. BC/CMC0.9 exhibited the lower liquid uptake (up to 11 times lower), suggesting that the more linear structure of the intermediate substitute CMC grade (0.9) was able to interact more strongly with BC, resulting in a denser structure. All samples showed a typical burst release effect in the first 15 min of test, however the BC/CMC0.9 biocomposite promoted a slight lowering of MTX release rates, suggesting that the DS of CMC can be considered the key factor to modulate the BC properties.
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spelling Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release propertiesBacterial celluloseCarboxymethylcelluloseControlled releaseIn situ modificationMethotrexateBacterial cellulose/carboxymethylcelullose (BC/CMC) biocomposites with different DS-CMC (DS from 0.7 to 1.2) were developed in order to evaluate their impact as a drug delivery system. Biocomposites were loaded with methotrexate (MTX) as an alternative for the topical treatment of psoriasis. Scanning electron microscopy and atomic force microscopy showed that the CMC coated the cellulose nanofibers, leading to the decrease of the elastic modulus as the DS of CMC increased. BC/CMC0.9 exhibited the lower liquid uptake (up to 11 times lower), suggesting that the more linear structure of the intermediate substitute CMC grade (0.9) was able to interact more strongly with BC, resulting in a denser structure. All samples showed a typical burst release effect in the first 15 min of test, however the BC/CMC0.9 biocomposite promoted a slight lowering of MTX release rates, suggesting that the DS of CMC can be considered the key factor to modulate the BC properties.University of Araraquara – U NIARAInstitute of Chemistry São Paulo State University – UNESPInterdisciplinary Laboratory of Advanced Materials Centro de Ciências da Natureza- CNN Federal University of Piaui – UFPIGroup ‘Materials + Technologies’ (GMT) Department of Chemical and Environmental Engineering Engineering College of Gipuzkoa University of the Basque Country (UPV/EHU)Department of Drugs and Pharmaceuticals School of Pharmaceutical Sciences SãoPaulo State University – UNESPInstitute of Chemistry São Paulo State University – UNESPDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences SãoPaulo State University – UNESPNIARAUniversidade Estadual Paulista (Unesp)Federal University of Piaui – UFPIUniversity of the Basque Country (UPV/EHU)de Lima Fontes, MarinaMeneguin, Andréia BagliottiTercjak, AgnieszkaGutierrez, JunkalCury, Beatriz Stringhetti Ferreira [UNESP]dos Santos, Aline Martins [UNESP]Ribeiro, Sidney J.L. [UNESP]Barud, Hernane S. [UNESP]2018-12-11T17:15:05Z2018-12-11T17:15:05Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article126-134application/pdfhttp://dx.doi.org/10.1016/j.carbpol.2017.09.061Carbohydrate Polymers, v. 179, p. 126-134.0144-8617http://hdl.handle.net/11449/17527110.1016/j.carbpol.2017.09.0612-s2.0-850301588022-s2.0-85030158802.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymers1,428info:eu-repo/semantics/openAccess2024-06-24T13:45:38Zoai:repositorio.unesp.br:11449/175271Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:47:08.842810Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
title Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
spellingShingle Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
de Lima Fontes, Marina
Bacterial cellulose
Carboxymethylcellulose
Controlled release
In situ modification
Methotrexate
title_short Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
title_full Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
title_fullStr Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
title_full_unstemmed Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
title_sort Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties
author de Lima Fontes, Marina
author_facet de Lima Fontes, Marina
Meneguin, Andréia Bagliotti
Tercjak, Agnieszka
Gutierrez, Junkal
Cury, Beatriz Stringhetti Ferreira [UNESP]
dos Santos, Aline Martins [UNESP]
Ribeiro, Sidney J.L. [UNESP]
Barud, Hernane S. [UNESP]
author_role author
author2 Meneguin, Andréia Bagliotti
Tercjak, Agnieszka
Gutierrez, Junkal
Cury, Beatriz Stringhetti Ferreira [UNESP]
dos Santos, Aline Martins [UNESP]
Ribeiro, Sidney J.L. [UNESP]
Barud, Hernane S. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NIARA
Universidade Estadual Paulista (Unesp)
Federal University of Piaui – UFPI
University of the Basque Country (UPV/EHU)
dc.contributor.author.fl_str_mv de Lima Fontes, Marina
Meneguin, Andréia Bagliotti
Tercjak, Agnieszka
Gutierrez, Junkal
Cury, Beatriz Stringhetti Ferreira [UNESP]
dos Santos, Aline Martins [UNESP]
Ribeiro, Sidney J.L. [UNESP]
Barud, Hernane S. [UNESP]
dc.subject.por.fl_str_mv Bacterial cellulose
Carboxymethylcellulose
Controlled release
In situ modification
Methotrexate
topic Bacterial cellulose
Carboxymethylcellulose
Controlled release
In situ modification
Methotrexate
description Bacterial cellulose/carboxymethylcelullose (BC/CMC) biocomposites with different DS-CMC (DS from 0.7 to 1.2) were developed in order to evaluate their impact as a drug delivery system. Biocomposites were loaded with methotrexate (MTX) as an alternative for the topical treatment of psoriasis. Scanning electron microscopy and atomic force microscopy showed that the CMC coated the cellulose nanofibers, leading to the decrease of the elastic modulus as the DS of CMC increased. BC/CMC0.9 exhibited the lower liquid uptake (up to 11 times lower), suggesting that the more linear structure of the intermediate substitute CMC grade (0.9) was able to interact more strongly with BC, resulting in a denser structure. All samples showed a typical burst release effect in the first 15 min of test, however the BC/CMC0.9 biocomposite promoted a slight lowering of MTX release rates, suggesting that the DS of CMC can be considered the key factor to modulate the BC properties.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:15:05Z
2018-12-11T17:15:05Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.carbpol.2017.09.061
Carbohydrate Polymers, v. 179, p. 126-134.
0144-8617
http://hdl.handle.net/11449/175271
10.1016/j.carbpol.2017.09.061
2-s2.0-85030158802
2-s2.0-85030158802.pdf
url http://dx.doi.org/10.1016/j.carbpol.2017.09.061
http://hdl.handle.net/11449/175271
identifier_str_mv Carbohydrate Polymers, v. 179, p. 126-134.
0144-8617
10.1016/j.carbpol.2017.09.061
2-s2.0-85030158802
2-s2.0-85030158802.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carbohydrate Polymers
1,428
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 126-134
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128857339854848

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