Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/219189 |
Resumo: | Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to he EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained. |
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Repositório Institucional da UNESP |
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spelling |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein geneBoth Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to he EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained.Departments of Pathology City of Hope National Medical Center, Duarte, CAState University of Sao Paulo, BotucatuUniversity of Campinas (UNICAMP), Campinas, Sao PauloDivision of Pathology City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010City of Hope National Medical CenterUniversidade de São Paulo (USP)Universidade Estadual de Campinas (UNICAMP)Chen, Wen-GangChen, Yuan-YuanBacchi, Maura M.Bacchi, Carlos E.Alvarenga, MarceloWeiss, Lawrence M.2022-04-28T18:54:09Z2022-04-28T18:54:09Z1996-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17-23American Journal of Pathology, v. 148, n. 1, p. 17-23, 1996.0002-9440http://hdl.handle.net/11449/2191892-s2.0-0030044326Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Pathologyinfo:eu-repo/semantics/openAccess2022-04-28T18:54:09Zoai:repositorio.unesp.br:11449/219189Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T18:54:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
title |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
spellingShingle |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene Chen, Wen-Gang |
title_short |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
title_full |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
title_fullStr |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
title_full_unstemmed |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
title_sort |
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene |
author |
Chen, Wen-Gang |
author_facet |
Chen, Wen-Gang Chen, Yuan-Yuan Bacchi, Maura M. Bacchi, Carlos E. Alvarenga, Marcelo Weiss, Lawrence M. |
author_role |
author |
author2 |
Chen, Yuan-Yuan Bacchi, Maura M. Bacchi, Carlos E. Alvarenga, Marcelo Weiss, Lawrence M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
City of Hope National Medical Center Universidade de São Paulo (USP) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Chen, Wen-Gang Chen, Yuan-Yuan Bacchi, Maura M. Bacchi, Carlos E. Alvarenga, Marcelo Weiss, Lawrence M. |
description |
Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to he EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-01-01 2022-04-28T18:54:09Z 2022-04-28T18:54:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
American Journal of Pathology, v. 148, n. 1, p. 17-23, 1996. 0002-9440 http://hdl.handle.net/11449/219189 2-s2.0-0030044326 |
identifier_str_mv |
American Journal of Pathology, v. 148, n. 1, p. 17-23, 1996. 0002-9440 2-s2.0-0030044326 |
url |
http://hdl.handle.net/11449/219189 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17-23 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789827470458880 |