Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1123/JPAH.2020-0442 http://hdl.handle.net/11449/207945 |
Resumo: | Background: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile. |
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Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide SynthaseAgingCardiovascular healthChronic diseaseTreadmill walkBackground: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile.Department of Physical Education School of Sciences Saõ Paulo State University (UNESP)Department of Genetics Faculty of Medicine University of Saõ PauloDepartment of Pharmacology Ribeiraõ Preto Medical School University of Saõ PauloRibeiraõ Preto College of Nursing University of Saõ PauloBauru School of Dentistry University of Saõ PauloDepartment of Physical Education School of Sciences Saõ Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)University of Saõ PauloReia, Thaís Amanda [UNESP]Silva, Roberta Fernanda Da [UNESP]Jacomini, André Mouraõ [UNESP]Moreno, Ana Maria Guilmo [UNESP]Ferezin, Letícia PerticarraPereira, Sherliane CarlaLacchini, RiccardoDionísio, Thiago JoséSantos, Carlos FerreiraZago, Anderson Saranz [UNESP]2021-06-25T11:03:39Z2021-06-25T11:03:39Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article516-523http://dx.doi.org/10.1123/JPAH.2020-0442Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021.1543-54741543-3080http://hdl.handle.net/11449/20794510.1123/JPAH.2020-04422-s2.0-85105587049Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Physical Activity and Healthinfo:eu-repo/semantics/openAccess2024-08-15T18:47:15Zoai:repositorio.unesp.br:11449/207945Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:47:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
title |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
spellingShingle |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase Reia, Thaís Amanda [UNESP] Aging Cardiovascular health Chronic disease Treadmill walk |
title_short |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
title_full |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
title_fullStr |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
title_full_unstemmed |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
title_sort |
Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase |
author |
Reia, Thaís Amanda [UNESP] |
author_facet |
Reia, Thaís Amanda [UNESP] Silva, Roberta Fernanda Da [UNESP] Jacomini, André Mouraõ [UNESP] Moreno, Ana Maria Guilmo [UNESP] Ferezin, Letícia Perticarra Pereira, Sherliane Carla Lacchini, Riccardo Dionísio, Thiago José Santos, Carlos Ferreira Zago, Anderson Saranz [UNESP] |
author_role |
author |
author2 |
Silva, Roberta Fernanda Da [UNESP] Jacomini, André Mouraõ [UNESP] Moreno, Ana Maria Guilmo [UNESP] Ferezin, Letícia Perticarra Pereira, Sherliane Carla Lacchini, Riccardo Dionísio, Thiago José Santos, Carlos Ferreira Zago, Anderson Saranz [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Saõ Paulo |
dc.contributor.author.fl_str_mv |
Reia, Thaís Amanda [UNESP] Silva, Roberta Fernanda Da [UNESP] Jacomini, André Mouraõ [UNESP] Moreno, Ana Maria Guilmo [UNESP] Ferezin, Letícia Perticarra Pereira, Sherliane Carla Lacchini, Riccardo Dionísio, Thiago José Santos, Carlos Ferreira Zago, Anderson Saranz [UNESP] |
dc.subject.por.fl_str_mv |
Aging Cardiovascular health Chronic disease Treadmill walk |
topic |
Aging Cardiovascular health Chronic disease Treadmill walk |
description |
Background: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:03:39Z 2021-06-25T11:03:39Z 2021-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1123/JPAH.2020-0442 Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021. 1543-5474 1543-3080 http://hdl.handle.net/11449/207945 10.1123/JPAH.2020-0442 2-s2.0-85105587049 |
url |
http://dx.doi.org/10.1123/JPAH.2020-0442 http://hdl.handle.net/11449/207945 |
identifier_str_mv |
Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021. 1543-5474 1543-3080 10.1123/JPAH.2020-0442 2-s2.0-85105587049 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Physical Activity and Health |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
516-523 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128175293595648 |