Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase

Detalhes bibliográficos
Autor(a) principal: Reia, Thaís Amanda [UNESP]
Data de Publicação: 2021
Outros Autores: Silva, Roberta Fernanda Da [UNESP], Jacomini, André Mouraõ [UNESP], Moreno, Ana Maria Guilmo [UNESP], Ferezin, Letícia Perticarra, Pereira, Sherliane Carla, Lacchini, Riccardo, Dionísio, Thiago José, Santos, Carlos Ferreira, Zago, Anderson Saranz [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1123/JPAH.2020-0442
http://hdl.handle.net/11449/207945
Resumo: Background: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile.
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spelling Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide SynthaseAgingCardiovascular healthChronic diseaseTreadmill walkBackground: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile.Department of Physical Education School of Sciences Saõ Paulo State University (UNESP)Department of Genetics Faculty of Medicine University of Saõ PauloDepartment of Pharmacology Ribeiraõ Preto Medical School University of Saõ PauloRibeiraõ Preto College of Nursing University of Saõ PauloBauru School of Dentistry University of Saõ PauloDepartment of Physical Education School of Sciences Saõ Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)University of Saõ PauloReia, Thaís Amanda [UNESP]Silva, Roberta Fernanda Da [UNESP]Jacomini, André Mouraõ [UNESP]Moreno, Ana Maria Guilmo [UNESP]Ferezin, Letícia PerticarraPereira, Sherliane CarlaLacchini, RiccardoDionísio, Thiago JoséSantos, Carlos FerreiraZago, Anderson Saranz [UNESP]2021-06-25T11:03:39Z2021-06-25T11:03:39Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article516-523http://dx.doi.org/10.1123/JPAH.2020-0442Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021.1543-54741543-3080http://hdl.handle.net/11449/20794510.1123/JPAH.2020-04422-s2.0-85105587049Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Physical Activity and Healthinfo:eu-repo/semantics/openAccess2024-08-15T18:47:15Zoai:repositorio.unesp.br:11449/207945Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:47:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
title Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
spellingShingle Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
Reia, Thaís Amanda [UNESP]
Aging
Cardiovascular health
Chronic disease
Treadmill walk
title_short Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
title_full Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
title_fullStr Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
title_full_unstemmed Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
title_sort Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults with Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase
author Reia, Thaís Amanda [UNESP]
author_facet Reia, Thaís Amanda [UNESP]
Silva, Roberta Fernanda Da [UNESP]
Jacomini, André Mouraõ [UNESP]
Moreno, Ana Maria Guilmo [UNESP]
Ferezin, Letícia Perticarra
Pereira, Sherliane Carla
Lacchini, Riccardo
Dionísio, Thiago José
Santos, Carlos Ferreira
Zago, Anderson Saranz [UNESP]
author_role author
author2 Silva, Roberta Fernanda Da [UNESP]
Jacomini, André Mouraõ [UNESP]
Moreno, Ana Maria Guilmo [UNESP]
Ferezin, Letícia Perticarra
Pereira, Sherliane Carla
Lacchini, Riccardo
Dionísio, Thiago José
Santos, Carlos Ferreira
Zago, Anderson Saranz [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Saõ Paulo
dc.contributor.author.fl_str_mv Reia, Thaís Amanda [UNESP]
Silva, Roberta Fernanda Da [UNESP]
Jacomini, André Mouraõ [UNESP]
Moreno, Ana Maria Guilmo [UNESP]
Ferezin, Letícia Perticarra
Pereira, Sherliane Carla
Lacchini, Riccardo
Dionísio, Thiago José
Santos, Carlos Ferreira
Zago, Anderson Saranz [UNESP]
dc.subject.por.fl_str_mv Aging
Cardiovascular health
Chronic disease
Treadmill walk
topic Aging
Cardiovascular health
Chronic disease
Treadmill walk
description Background: This study aimed to analyze the acute effect of physical exercise on nitric oxide concentration and blood pressure (BP) in older adults with different levels of training status (TS) and verified the influence of endothelial nitric oxide synthase polymorphisms on these variables. Methods: A total of 145 older adults were divided into good TS (G1) and weak TS (G2). Participants were subjected to a 40-minute treadmill walk (40%-60% of maximum oxygen consumption) with BP measurements and blood collections for plasma nitrite and oxidative stress biomarkers at pretest and posttest moments. Data were analyzed by 2-way repeated-measures with Sidak post hoc test (P < .05) and multivariate linear analysis. Results: After acute exercise, G2 showed an increase in oxidative stress biomarkers (P = .008), and both groups showed an increase in systolic BP (P < .001). Polymorphisms 894G > T and intron 4b/a had no association with nitrite and BP. However,-786T > C polymorphism showed an association with reduced systolic and diastolic BP (TT genotype) and increased diastolic BP (TC genotype). Higher TS level was also associated with lower BP. Conclusion: The maintenance of good TS levels may have a protective effect on cardiovascular risks regardless of the genetic profile.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:03:39Z
2021-06-25T11:03:39Z
2021-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1123/JPAH.2020-0442
Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021.
1543-5474
1543-3080
http://hdl.handle.net/11449/207945
10.1123/JPAH.2020-0442
2-s2.0-85105587049
url http://dx.doi.org/10.1123/JPAH.2020-0442
http://hdl.handle.net/11449/207945
identifier_str_mv Journal of Physical Activity and Health, v. 18, n. 5, p. 516-523, 2021.
1543-5474
1543-3080
10.1123/JPAH.2020-0442
2-s2.0-85105587049
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Physical Activity and Health
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 516-523
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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