A control theoretic approach to the treatment of AIDS
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.23919/ecc.2001.7076465 http://hdl.handle.net/11449/220497 |
Resumo: | This work concerns the problem of optimizing the drug doses in the treatment of AIDS by looking for a balance between the therapeutic response and the side effects. Extensive computer simulation and comparison with the constant dose scheme evaluate the results. For some few cases the results are also compared with actual clinical data. A mathematical model describing the dynamics of HIV virus and CD4 cells is initially fitted to actual published clinical data. The identified model is then used to compute the sub-optimal drug doses for the treatment of AIDS by a direct method of optimization using a performance index of Bolza type. The sub-optimal treatment scheme is shown to achieve a therapeutic response close to the constant dose strategy, but with lower cost, as measured by the proposed performance index. |
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Repositório Institucional da UNESP |
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2946 |
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A control theoretic approach to the treatment of AIDSfarmacotherapyOptimal controloptimizationsimulationviral infectionsThis work concerns the problem of optimizing the drug doses in the treatment of AIDS by looking for a balance between the therapeutic response and the side effects. Extensive computer simulation and comparison with the constant dose scheme evaluate the results. For some few cases the results are also compared with actual clinical data. A mathematical model describing the dynamics of HIV virus and CD4 cells is initially fitted to actual published clinical data. The identified model is then used to compute the sub-optimal drug doses for the treatment of AIDS by a direct method of optimization using a performance index of Bolza type. The sub-optimal treatment scheme is shown to achieve a therapeutic response close to the constant dose strategy, but with lower cost, as measured by the proposed performance index.Department of Electromechanical Eng. UBI - Universidade Beira InteriorDepartment of Statistics Comp. and Applied Maths UNESP Univ. Estadual PaulistaITA - Institute Tecnológico de AeronáUticaDepartment of Statistics Comp. and Applied Maths UNESP Univ. Estadual PaulistaUBI - Universidade Beira InteriorUniversidade Estadual Paulista (UNESP)ITA - Institute Tecnológico de AeronáUticaDe Souza, José A. M. FelippeCaetano, Marco Antonio Leonel [UNESP]Yoneyama, Takashi2022-04-28T19:01:45Z2022-04-28T19:01:45Z2001-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject3434-3439http://dx.doi.org/10.23919/ecc.2001.70764652001 European Control Conference, ECC 2001, p. 3434-3439.http://hdl.handle.net/11449/22049710.23919/ecc.2001.70764652-s2.0-84947484304Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPeng2001 European Control Conference, ECC 2001info:eu-repo/semantics/openAccess2022-04-28T19:01:45Zoai:repositorio.unesp.br:11449/220497Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:06:33.993666Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A control theoretic approach to the treatment of AIDS |
title |
A control theoretic approach to the treatment of AIDS |
spellingShingle |
A control theoretic approach to the treatment of AIDS De Souza, José A. M. Felippe farmacotherapy Optimal control optimization simulation viral infections |
title_short |
A control theoretic approach to the treatment of AIDS |
title_full |
A control theoretic approach to the treatment of AIDS |
title_fullStr |
A control theoretic approach to the treatment of AIDS |
title_full_unstemmed |
A control theoretic approach to the treatment of AIDS |
title_sort |
A control theoretic approach to the treatment of AIDS |
author |
De Souza, José A. M. Felippe |
author_facet |
De Souza, José A. M. Felippe Caetano, Marco Antonio Leonel [UNESP] Yoneyama, Takashi |
author_role |
author |
author2 |
Caetano, Marco Antonio Leonel [UNESP] Yoneyama, Takashi |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
UBI - Universidade Beira Interior Universidade Estadual Paulista (UNESP) ITA - Institute Tecnológico de AeronáUtica |
dc.contributor.author.fl_str_mv |
De Souza, José A. M. Felippe Caetano, Marco Antonio Leonel [UNESP] Yoneyama, Takashi |
dc.subject.por.fl_str_mv |
farmacotherapy Optimal control optimization simulation viral infections |
topic |
farmacotherapy Optimal control optimization simulation viral infections |
description |
This work concerns the problem of optimizing the drug doses in the treatment of AIDS by looking for a balance between the therapeutic response and the side effects. Extensive computer simulation and comparison with the constant dose scheme evaluate the results. For some few cases the results are also compared with actual clinical data. A mathematical model describing the dynamics of HIV virus and CD4 cells is initially fitted to actual published clinical data. The identified model is then used to compute the sub-optimal drug doses for the treatment of AIDS by a direct method of optimization using a performance index of Bolza type. The sub-optimal treatment scheme is shown to achieve a therapeutic response close to the constant dose strategy, but with lower cost, as measured by the proposed performance index. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-01-01 2022-04-28T19:01:45Z 2022-04-28T19:01:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.23919/ecc.2001.7076465 2001 European Control Conference, ECC 2001, p. 3434-3439. http://hdl.handle.net/11449/220497 10.23919/ecc.2001.7076465 2-s2.0-84947484304 |
url |
http://dx.doi.org/10.23919/ecc.2001.7076465 http://hdl.handle.net/11449/220497 |
identifier_str_mv |
2001 European Control Conference, ECC 2001, p. 3434-3439. 10.23919/ecc.2001.7076465 2-s2.0-84947484304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2001 European Control Conference, ECC 2001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3434-3439 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128756540243968 |