Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/tri.13865 http://hdl.handle.net/11449/210427 |
Resumo: | This retrospective multicenter (n = 18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87.7% among centers. Risk factors ((lower-bound-95%CI) OR (upper-bound-95%CI)) were male gender ((1.066)1.249(1.463)), diabetic kidney disease ((1.053)1.296(1.595)), time on dialysis ((1.005)1.007(1.009)), retransplantation ((1.035)1.397(1.885)), preformed anti-HLA antibodies ((1.011)1.383(1.892)), HLA mismatches ((1.006)1.066(1.130)), donor age ((1.011)1.017(1.023)), donor final serum creatinine (sCr) ((1.239)1.317(1.399)), cold ischemia time (CIT) ((1.031)1.043(1.056)), machine perfusion ((0.401)0.542(0.733)), and induction therapy with rabbit antithymocyte globulin (rATG) ((0.658)0.800(0.973)). Duration of DGF > 4 days was associated with inferior renal function and DGF > 14 days with the higher incidences of acute rejection, graft loss, and death. In conclusion, the incidence and duration of DGF were high and associated with inferior graft outcomes. While late referral and poor donor maintenance account for the high overall incidence of DGF, variability in donor and recipient selection, organ preservation method, and type of induction agent may account for the wide variation observed among transplant centers. |
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Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter studyBrazildelayed graft functionkidney transplantThis retrospective multicenter (n = 18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87.7% among centers. Risk factors ((lower-bound-95%CI) OR (upper-bound-95%CI)) were male gender ((1.066)1.249(1.463)), diabetic kidney disease ((1.053)1.296(1.595)), time on dialysis ((1.005)1.007(1.009)), retransplantation ((1.035)1.397(1.885)), preformed anti-HLA antibodies ((1.011)1.383(1.892)), HLA mismatches ((1.006)1.066(1.130)), donor age ((1.011)1.017(1.023)), donor final serum creatinine (sCr) ((1.239)1.317(1.399)), cold ischemia time (CIT) ((1.031)1.043(1.056)), machine perfusion ((0.401)0.542(0.733)), and induction therapy with rabbit antithymocyte globulin (rATG) ((0.658)0.800(0.973)). Duration of DGF > 4 days was associated with inferior renal function and DGF > 14 days with the higher incidences of acute rejection, graft loss, and death. In conclusion, the incidence and duration of DGF were high and associated with inferior graft outcomes. While late referral and poor donor maintenance account for the high overall incidence of DGF, variability in donor and recipient selection, organ preservation method, and type of induction agent may account for the wide variation observed among transplant centers.Associacao Brasileira de Transplantes de Orgaos, ABTOUniv Fed Cear, Dept Med Clin, Fortaleza, CE, BrazilHosp Geral Fortaleza, Fortaleza, CE, BrazilHosp Clin Univ Campinas, Campinas, SP, BrazilHosp Clin Porto Alegre, Porto Alegre, RS, BrazilUniv Estadual Paulista, Dept Med Interna, Botucatu, SP, BrazilFundacao Oswaldo Ramos, Hosp Rim, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, BrazilSanta Casa Miserordia Porto Alegre, Porto Alegre, RS, BrazilHosp Sao Francisco Providencia Deus, Rio De Janeiro, RJ, BrazilHosp Univ Walter Cantidio, Fortaleza, CE, BrazilHosp Santa Isabel, Blumenau, SC, BrazilFundacao Prorim, Hosp Municipal Sao Jos Joinville, Joinville, SC, BrazilUniv Sao Paulo, Hosp Clin, Sao Paulo, SP, BrazilReal Hosp Portugues Benefencia Pernambuco, Recife, PE, BrazilHosp Israelita Albert Einstein, Sao Paulo, SP, BrazilSanta Casa Miserordia Juiz De Fora, Juiz De Fora, MG, BrazilHosp Felicio Rocho, Belo Horizonte, MG, BrazilHosp Univ Cajuru, Curitiba, PR, BrazilSanta Casa Montes Claros, Montes Claros, MG, BrazilHosp Univ Ciencias Med, Belo Horizonte, MG, BrazilUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, BrazilUniv Estadual Paulista, Dept Med Interna, Botucatu, SP, BrazilWiley-BlackwellUniv Fed CearHosp Geral FortalezaUniversidade Estadual de Campinas (UNICAMP)Hosp Clin Porto AlegreUniversidade Estadual Paulista (Unesp)Fundacao Oswaldo RamosUniversidade Federal de São Paulo (UNIFESP)Santa Casa Miserordia Porto AlegreHosp Sao Francisco Providencia DeusHosp Univ Walter CantidioHosp Santa IsabelFundacao ProrimUniversidade de São Paulo (USP)Real Hosp Portugues Benefencia PernambucoHosp Israelita Albert EinsteinSanta Casa Miserordia Juiz De ForaHosp Felicio RochoHosp Univ CajuruSanta Casa Montes ClarosHosp Univ Ciencias MedUniv Fed Ciencias Saude Porto AlegreSandes-Freitas, Taina Veras deMazzali, MarildaManfro, Roberto CerattiAndrade, Luis Gustavo Modelli de [UNESP]Vicari, Alessandra RosaSousa, Marcos Vinicius deMedina Pestana, Jose OsmarGarcia, Valter DuroCarvalho, Deise Rosa de Boni Monteiro deMatos Esmeraldo, Ronaldo deOliveira, Claudia Maria Costa deSimao, Denise RodriguesDeboni, Luciane MonicaDavid-Neto, EliasCavalcanti, Frederico Castelo BrancoPacheco-Silva, AlvaroFerreira, Gustavo FernandesMadeira, Rafael LageBignelli, Alexandre TortozaMeira, Geraldo Sergio GoncalvesLasmar, Euler PaceKeitel, ElizeteAzevedo Matuck, Tereza deCosta, Silvana Daher daNga, Hong Si [UNESP]Fernandes, Paula Frassinetti Castelo Branco CamurcaNarciso, Humberto RebelloVieira, Marcos AlexandreAgena, FabianaFonseca, Ivailda BarbosaMatos, Ana Cristina Carvalho deBastos, JulianaVillaca, Sandra SimoneHokazono, Silvia ReginaSilva, Alberto Rafael BaleeiroLasmar, MarcusTedesco-Silva, HelioDGF-Brazil Study Grp2021-06-25T15:20:12Z2021-06-25T15:20:12Z2021-04-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.1111/tri.13865Transplant International. Hoboken: Wiley, 12 p., 2021.0934-0874http://hdl.handle.net/11449/21042710.1111/tri.13865WOS:000643915300001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTransplant Internationalinfo:eu-repo/semantics/openAccess2021-10-23T20:17:31Zoai:repositorio.unesp.br:11449/210427Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T20:17:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
title |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
spellingShingle |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study Sandes-Freitas, Taina Veras de Brazil delayed graft function kidney transplant |
title_short |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
title_full |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
title_fullStr |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
title_full_unstemmed |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
title_sort |
Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study |
author |
Sandes-Freitas, Taina Veras de |
author_facet |
Sandes-Freitas, Taina Veras de Mazzali, Marilda Manfro, Roberto Ceratti Andrade, Luis Gustavo Modelli de [UNESP] Vicari, Alessandra Rosa Sousa, Marcos Vinicius de Medina Pestana, Jose Osmar Garcia, Valter Duro Carvalho, Deise Rosa de Boni Monteiro de Matos Esmeraldo, Ronaldo de Oliveira, Claudia Maria Costa de Simao, Denise Rodrigues Deboni, Luciane Monica David-Neto, Elias Cavalcanti, Frederico Castelo Branco Pacheco-Silva, Alvaro Ferreira, Gustavo Fernandes Madeira, Rafael Lage Bignelli, Alexandre Tortoza Meira, Geraldo Sergio Goncalves Lasmar, Euler Pace Keitel, Elizete Azevedo Matuck, Tereza de Costa, Silvana Daher da Nga, Hong Si [UNESP] Fernandes, Paula Frassinetti Castelo Branco Camurca Narciso, Humberto Rebello Vieira, Marcos Alexandre Agena, Fabiana Fonseca, Ivailda Barbosa Matos, Ana Cristina Carvalho de Bastos, Juliana Villaca, Sandra Simone Hokazono, Silvia Regina Silva, Alberto Rafael Baleeiro Lasmar, Marcus Tedesco-Silva, Helio DGF-Brazil Study Grp |
author_role |
author |
author2 |
Mazzali, Marilda Manfro, Roberto Ceratti Andrade, Luis Gustavo Modelli de [UNESP] Vicari, Alessandra Rosa Sousa, Marcos Vinicius de Medina Pestana, Jose Osmar Garcia, Valter Duro Carvalho, Deise Rosa de Boni Monteiro de Matos Esmeraldo, Ronaldo de Oliveira, Claudia Maria Costa de Simao, Denise Rodrigues Deboni, Luciane Monica David-Neto, Elias Cavalcanti, Frederico Castelo Branco Pacheco-Silva, Alvaro Ferreira, Gustavo Fernandes Madeira, Rafael Lage Bignelli, Alexandre Tortoza Meira, Geraldo Sergio Goncalves Lasmar, Euler Pace Keitel, Elizete Azevedo Matuck, Tereza de Costa, Silvana Daher da Nga, Hong Si [UNESP] Fernandes, Paula Frassinetti Castelo Branco Camurca Narciso, Humberto Rebello Vieira, Marcos Alexandre Agena, Fabiana Fonseca, Ivailda Barbosa Matos, Ana Cristina Carvalho de Bastos, Juliana Villaca, Sandra Simone Hokazono, Silvia Regina Silva, Alberto Rafael Baleeiro Lasmar, Marcus Tedesco-Silva, Helio DGF-Brazil Study Grp |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Cear Hosp Geral Fortaleza Universidade Estadual de Campinas (UNICAMP) Hosp Clin Porto Alegre Universidade Estadual Paulista (Unesp) Fundacao Oswaldo Ramos Universidade Federal de São Paulo (UNIFESP) Santa Casa Miserordia Porto Alegre Hosp Sao Francisco Providencia Deus Hosp Univ Walter Cantidio Hosp Santa Isabel Fundacao Prorim Universidade de São Paulo (USP) Real Hosp Portugues Benefencia Pernambuco Hosp Israelita Albert Einstein Santa Casa Miserordia Juiz De Fora Hosp Felicio Rocho Hosp Univ Cajuru Santa Casa Montes Claros Hosp Univ Ciencias Med Univ Fed Ciencias Saude Porto Alegre |
dc.contributor.author.fl_str_mv |
Sandes-Freitas, Taina Veras de Mazzali, Marilda Manfro, Roberto Ceratti Andrade, Luis Gustavo Modelli de [UNESP] Vicari, Alessandra Rosa Sousa, Marcos Vinicius de Medina Pestana, Jose Osmar Garcia, Valter Duro Carvalho, Deise Rosa de Boni Monteiro de Matos Esmeraldo, Ronaldo de Oliveira, Claudia Maria Costa de Simao, Denise Rodrigues Deboni, Luciane Monica David-Neto, Elias Cavalcanti, Frederico Castelo Branco Pacheco-Silva, Alvaro Ferreira, Gustavo Fernandes Madeira, Rafael Lage Bignelli, Alexandre Tortoza Meira, Geraldo Sergio Goncalves Lasmar, Euler Pace Keitel, Elizete Azevedo Matuck, Tereza de Costa, Silvana Daher da Nga, Hong Si [UNESP] Fernandes, Paula Frassinetti Castelo Branco Camurca Narciso, Humberto Rebello Vieira, Marcos Alexandre Agena, Fabiana Fonseca, Ivailda Barbosa Matos, Ana Cristina Carvalho de Bastos, Juliana Villaca, Sandra Simone Hokazono, Silvia Regina Silva, Alberto Rafael Baleeiro Lasmar, Marcus Tedesco-Silva, Helio DGF-Brazil Study Grp |
dc.subject.por.fl_str_mv |
Brazil delayed graft function kidney transplant |
topic |
Brazil delayed graft function kidney transplant |
description |
This retrospective multicenter (n = 18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87.7% among centers. Risk factors ((lower-bound-95%CI) OR (upper-bound-95%CI)) were male gender ((1.066)1.249(1.463)), diabetic kidney disease ((1.053)1.296(1.595)), time on dialysis ((1.005)1.007(1.009)), retransplantation ((1.035)1.397(1.885)), preformed anti-HLA antibodies ((1.011)1.383(1.892)), HLA mismatches ((1.006)1.066(1.130)), donor age ((1.011)1.017(1.023)), donor final serum creatinine (sCr) ((1.239)1.317(1.399)), cold ischemia time (CIT) ((1.031)1.043(1.056)), machine perfusion ((0.401)0.542(0.733)), and induction therapy with rabbit antithymocyte globulin (rATG) ((0.658)0.800(0.973)). Duration of DGF > 4 days was associated with inferior renal function and DGF > 14 days with the higher incidences of acute rejection, graft loss, and death. In conclusion, the incidence and duration of DGF were high and associated with inferior graft outcomes. While late referral and poor donor maintenance account for the high overall incidence of DGF, variability in donor and recipient selection, organ preservation method, and type of induction agent may account for the wide variation observed among transplant centers. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T15:20:12Z 2021-06-25T15:20:12Z 2021-04-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/tri.13865 Transplant International. Hoboken: Wiley, 12 p., 2021. 0934-0874 http://hdl.handle.net/11449/210427 10.1111/tri.13865 WOS:000643915300001 |
url |
http://dx.doi.org/10.1111/tri.13865 http://hdl.handle.net/11449/210427 |
identifier_str_mv |
Transplant International. Hoboken: Wiley, 12 p., 2021. 0934-0874 10.1111/tri.13865 WOS:000643915300001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transplant International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964873294086144 |