Evaluation of the biocompatibility of silicone gel implants - histomorphometric study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5455/aim.2013.21.93-97 http://hdl.handle.net/11449/75428 |
Resumo: | Breast implants are medical devices that are used to augment breast size or to reconstruct the breast following mastectomy or to correct a congenital abnormality. Breast implants consist of a silicone outer shell and a filler (most commonly silicone gel or saline). Approximately 5 to 10 million women worldwide have breast implants. Histomorphometric study to evaluate the biological tissue compatibility of silicone implants suitable for plastic surgery and the adverse effects and risks of this material. Thirty Wistar white rats received subcutaneous implants and the revestiment of silicone gel Silimed ®®, and randomized into six groups of five animals each, according to the type of implanted material and the time of sacrifice. Eight areas of 60.11mm2 corresponding to the obtained surgical pieces were analyzed, counting mesenchymal cells, eosinophils, and foreign body giant cells, observing an acceptable biocompatibility in all implants, for subsequent statistical analysis by Tukey test. Silicone gel showed inflammation slightly greater than for other groups, with tissue reactions varying from light to moderate, whose result was the formation of a fibrous capsule around the material, recognized by the organism as a foreign body. Despite frequent local complications and adverse outcomes, this research showed that the silicone and top layer presented an acceptable chronic inflammatory reaction, which did not significantly differ from the control group. In general, it is possible to affirm that silicone gel had acceptable levels of biocompatibility, confirmed the rare presence of foreign body giant cells, and when of the rupture, formed a fibrous capsule around the material, separating the material of the organism. © AVICENA 2013. |
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Evaluation of the biocompatibility of silicone gel implants - histomorphometric studyBreast ImplantationMaterials TestingRatsSilicone GelsWistarsilicone geladverse outcomeanimal experimentanimal tissuebiocompatibilitycontrolled studyeosinophilevaluationfibroblastgiant cellhistocompatibilityinflammationinflammatory cellinflammatory infiltratemorphometricsnonhumanplastic surgeryqualitative analysisratrisk assessmentsilicone prosthesistissue reactionBreast implants are medical devices that are used to augment breast size or to reconstruct the breast following mastectomy or to correct a congenital abnormality. Breast implants consist of a silicone outer shell and a filler (most commonly silicone gel or saline). Approximately 5 to 10 million women worldwide have breast implants. Histomorphometric study to evaluate the biological tissue compatibility of silicone implants suitable for plastic surgery and the adverse effects and risks of this material. Thirty Wistar white rats received subcutaneous implants and the revestiment of silicone gel Silimed ®®, and randomized into six groups of five animals each, according to the type of implanted material and the time of sacrifice. Eight areas of 60.11mm2 corresponding to the obtained surgical pieces were analyzed, counting mesenchymal cells, eosinophils, and foreign body giant cells, observing an acceptable biocompatibility in all implants, for subsequent statistical analysis by Tukey test. Silicone gel showed inflammation slightly greater than for other groups, with tissue reactions varying from light to moderate, whose result was the formation of a fibrous capsule around the material, recognized by the organism as a foreign body. Despite frequent local complications and adverse outcomes, this research showed that the silicone and top layer presented an acceptable chronic inflammatory reaction, which did not significantly differ from the control group. In general, it is possible to affirm that silicone gel had acceptable levels of biocompatibility, confirmed the rare presence of foreign body giant cells, and when of the rupture, formed a fibrous capsule around the material, separating the material of the organism. © AVICENA 2013.Pediatric Dentistry, Araçatuba School of Dentistry, UNESP Stomatologist of CEOPE - State Center of Dentistry for Patients with Special Needs Department of Univag- Academic Center, Várzea Grande, MTPathology and Clinical Propaedeutics Department - Unesp Araçatuba School of Dentistry São Paulo State University, SPSocial and Pediatric Dentistry-Unesp Araçatuba School of Dentistry São Paulo State University, SPDepartment of Prosthodontics Unesp, Araçatuba School of Dentistry São Paulo State University, SPPediatric Dentistry, Araçatuba School of Dentistry, UNESP Stomatologist of CEOPE - State Center of Dentistry for Patients with Special Needs Department of Univag- Academic Center, Várzea Grande, MTPathology and Clinical Propaedeutics Department - Unesp Araçatuba School of Dentistry São Paulo State University, SPSocial and Pediatric Dentistry-Unesp Araçatuba School of Dentistry São Paulo State University, SPDepartment of Prosthodontics Unesp, Araçatuba School of Dentistry São Paulo State University, SPUniversidade Estadual Paulista (Unesp)França, Diurianne Caroline Campos [UNESP]Castro, Alvimar Lima de [UNESP]Soubhia, Ana Maria Pires [UNESP]Aguiar, Sandra Maria Herondina Coelho Ávila de [UNESP]Goiato, Marcelo Coelho [UNESP]2014-05-27T11:29:32Z2014-05-27T11:29:32Z2013-05-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-97application/pdfhttp://dx.doi.org/10.5455/aim.2013.21.93-97Acta Informatica Medica, v. 21, n. 2, p. 93-97, 2013.0353-81091986-5988http://hdl.handle.net/11449/7542810.5455/aim.2013.21.93-972-s2.0-848778822992-s2.0-84877882299.pdf8039557526741132642103216914689497198838148725820000-0002-3800-3050Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Informatica Medica0,275info:eu-repo/semantics/openAccess2023-12-19T06:26:28Zoai:repositorio.unesp.br:11449/75428Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-19T06:26:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
title |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
spellingShingle |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study França, Diurianne Caroline Campos [UNESP] Breast Implantation Materials Testing Rats Silicone Gels Wistar silicone gel adverse outcome animal experiment animal tissue biocompatibility controlled study eosinophil evaluation fibroblast giant cell histocompatibility inflammation inflammatory cell inflammatory infiltrate morphometrics nonhuman plastic surgery qualitative analysis rat risk assessment silicone prosthesis tissue reaction |
title_short |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
title_full |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
title_fullStr |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
title_full_unstemmed |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
title_sort |
Evaluation of the biocompatibility of silicone gel implants - histomorphometric study |
author |
França, Diurianne Caroline Campos [UNESP] |
author_facet |
França, Diurianne Caroline Campos [UNESP] Castro, Alvimar Lima de [UNESP] Soubhia, Ana Maria Pires [UNESP] Aguiar, Sandra Maria Herondina Coelho Ávila de [UNESP] Goiato, Marcelo Coelho [UNESP] |
author_role |
author |
author2 |
Castro, Alvimar Lima de [UNESP] Soubhia, Ana Maria Pires [UNESP] Aguiar, Sandra Maria Herondina Coelho Ávila de [UNESP] Goiato, Marcelo Coelho [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
França, Diurianne Caroline Campos [UNESP] Castro, Alvimar Lima de [UNESP] Soubhia, Ana Maria Pires [UNESP] Aguiar, Sandra Maria Herondina Coelho Ávila de [UNESP] Goiato, Marcelo Coelho [UNESP] |
dc.subject.por.fl_str_mv |
Breast Implantation Materials Testing Rats Silicone Gels Wistar silicone gel adverse outcome animal experiment animal tissue biocompatibility controlled study eosinophil evaluation fibroblast giant cell histocompatibility inflammation inflammatory cell inflammatory infiltrate morphometrics nonhuman plastic surgery qualitative analysis rat risk assessment silicone prosthesis tissue reaction |
topic |
Breast Implantation Materials Testing Rats Silicone Gels Wistar silicone gel adverse outcome animal experiment animal tissue biocompatibility controlled study eosinophil evaluation fibroblast giant cell histocompatibility inflammation inflammatory cell inflammatory infiltrate morphometrics nonhuman plastic surgery qualitative analysis rat risk assessment silicone prosthesis tissue reaction |
description |
Breast implants are medical devices that are used to augment breast size or to reconstruct the breast following mastectomy or to correct a congenital abnormality. Breast implants consist of a silicone outer shell and a filler (most commonly silicone gel or saline). Approximately 5 to 10 million women worldwide have breast implants. Histomorphometric study to evaluate the biological tissue compatibility of silicone implants suitable for plastic surgery and the adverse effects and risks of this material. Thirty Wistar white rats received subcutaneous implants and the revestiment of silicone gel Silimed ®®, and randomized into six groups of five animals each, according to the type of implanted material and the time of sacrifice. Eight areas of 60.11mm2 corresponding to the obtained surgical pieces were analyzed, counting mesenchymal cells, eosinophils, and foreign body giant cells, observing an acceptable biocompatibility in all implants, for subsequent statistical analysis by Tukey test. Silicone gel showed inflammation slightly greater than for other groups, with tissue reactions varying from light to moderate, whose result was the formation of a fibrous capsule around the material, recognized by the organism as a foreign body. Despite frequent local complications and adverse outcomes, this research showed that the silicone and top layer presented an acceptable chronic inflammatory reaction, which did not significantly differ from the control group. In general, it is possible to affirm that silicone gel had acceptable levels of biocompatibility, confirmed the rare presence of foreign body giant cells, and when of the rupture, formed a fibrous capsule around the material, separating the material of the organism. © AVICENA 2013. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05-23 2014-05-27T11:29:32Z 2014-05-27T11:29:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5455/aim.2013.21.93-97 Acta Informatica Medica, v. 21, n. 2, p. 93-97, 2013. 0353-8109 1986-5988 http://hdl.handle.net/11449/75428 10.5455/aim.2013.21.93-97 2-s2.0-84877882299 2-s2.0-84877882299.pdf 8039557526741132 6421032169146894 9719883814872582 0000-0002-3800-3050 |
url |
http://dx.doi.org/10.5455/aim.2013.21.93-97 http://hdl.handle.net/11449/75428 |
identifier_str_mv |
Acta Informatica Medica, v. 21, n. 2, p. 93-97, 2013. 0353-8109 1986-5988 10.5455/aim.2013.21.93-97 2-s2.0-84877882299 2-s2.0-84877882299.pdf 8039557526741132 6421032169146894 9719883814872582 0000-0002-3800-3050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Informatica Medica 0,275 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
93-97 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965341265166336 |