Hypoxia effects on oxidative stress and immunocompetence biomarkers in the mussel Perna perna (Mytilidae, Bivalvia)

• Autor(a) principal: Nogueira, L�lian [UNESP]
• Data de Publicação: 2017
• Outros Autores: Mello, Danielle Ferraz, Trevisan, Rafael, Garcia, Danielly [UNESP], da Silva Acosta, Daiane, Dafre, Alcir Luiz, de Almeida, Eduardo Alves [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.marenvres.2017.02.009; http://hdl.handle.net/11449/174289
• topic: Antioxidant defenses; Bivalves; Hemocytes; Immune system; Reduced oxygen levels

This study investigated the effects of hypoxia on oxidative stress response and immune function in mussels Perna perna exposed to air for 6, 12, 24 and 48�h. In air-exposed mussels, the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione reductase (GR) activities were lower in gill tissues (24–48�h) and digestive gland (12�h), while the glutathione peroxidase and GR activities were increased in the digestive gland (48�h). In both tissues, aerial exposure promoted a rapid (6�h) and persistent (up to 48�h) increase of glutathione levels. Decreased hemocyte count and viability, as well as increased phagocytic activity and cellular adhesion capacity were detected after prolonged aerial exposure (>12�h). In summary, induction of thiol pools, altered antioxidant enzyme activities, and activation of immune responses were detected in hypoxia exposed brown mussels, indicating hypoxia induced tissue-specific responses in both antioxidant and immune systems.