Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1161/01.hyp.19.2_suppl.ii149 http://hdl.handle.net/11449/223935 |
Resumo: | In the present study, we investigated changes in mesenteric, renal, and hindquarter vascular resistance during the pressor response produced by bilateral carotid occlusion (BCO) in conscious, freely moving normal and denervated (aortic, carotid, or both) rats. BCO was performed using special previously implanted cuffs. In control normal rats, the increase in mean arterial pressure (MAP) during early and late responses (37±4 and 21 ±2 mm Hg, respectively) was related to increased renal (125±12% and 45±10%) and mesenteric (38±13% and 41±5%) but not hindquarter (14±4% and 8±7%) vascular resistance. In aortic-denervated rats, the greater MAP increase in early and late responses (57±4 and 44±4 mm Hg, respectively) compared with normal rats was related to a marked increase in hindquarter (137±26% and 106±26%) and mesenteric (104±14% and 66±9%) vascular resistance. In carotid-denervated rats, MAP increase and change in vascular resistance were similar to those values observed in control rats. Sinoaortic-denervated rats showed a greater MAP increase (34±4 mm Hg) during late response and a reduced increase in renal vascular resistance (46±6%) during early response. The present results show that 1) the pressor response to BCO in normal rats is associated with an increase in renal and mesenteric vascular resistance, 2) the aortic baroreceptors buffer the increase in mesenteric and especially hindquarter vascular resistance during BCO, and 3) the reduced pressor response in late response is probably related to a reduced increase in renal vascular resistance during this component compared with the early response. © 1992 American Heart Association, Inc. |
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Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated ratsBaroreceptorsCarotid arteryIschemiaVascular resistanceIn the present study, we investigated changes in mesenteric, renal, and hindquarter vascular resistance during the pressor response produced by bilateral carotid occlusion (BCO) in conscious, freely moving normal and denervated (aortic, carotid, or both) rats. BCO was performed using special previously implanted cuffs. In control normal rats, the increase in mean arterial pressure (MAP) during early and late responses (37±4 and 21 ±2 mm Hg, respectively) was related to increased renal (125±12% and 45±10%) and mesenteric (38±13% and 41±5%) but not hindquarter (14±4% and 8±7%) vascular resistance. In aortic-denervated rats, the greater MAP increase in early and late responses (57±4 and 44±4 mm Hg, respectively) compared with normal rats was related to a marked increase in hindquarter (137±26% and 106±26%) and mesenteric (104±14% and 66±9%) vascular resistance. In carotid-denervated rats, MAP increase and change in vascular resistance were similar to those values observed in control rats. Sinoaortic-denervated rats showed a greater MAP increase (34±4 mm Hg) during late response and a reduced increase in renal vascular resistance (46±6%) during early response. The present results show that 1) the pressor response to BCO in normal rats is associated with an increase in renal and mesenteric vascular resistance, 2) the aortic baroreceptors buffer the increase in mesenteric and especially hindquarter vascular resistance during BCO, and 3) the reduced pressor response in late response is probably related to a reduced increase in renal vascular resistance during this component compared with the early response. © 1992 American Heart Association, Inc.Department of Physiology School of Medicine of Ribeirāo Prêto University of Sāo Paulo, Ribeirāo Prêto, SPDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SPDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SPUniversity of Sāo PauloUniversidade Estadual Paulista (UNESP)Machado, Benedito H.Bonagamba, Leni G. H.Castania, Jaci A.Menani, José V. [UNESP]2022-04-28T19:53:52Z2022-04-28T19:53:52Z1992-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleII-149-II-153http://dx.doi.org/10.1161/01.hyp.19.2_suppl.ii149Hypertension, v. 19, n. 2, p. II-149-II-153, 1992.1524-45630194-911Xhttp://hdl.handle.net/11449/22393510.1161/01.hyp.19.2_suppl.ii1492-s2.0-0026563590Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHypertensioninfo:eu-repo/semantics/openAccess2022-04-28T19:53:52Zoai:repositorio.unesp.br:11449/223935Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:53:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
title |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
spellingShingle |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats Machado, Benedito H. Baroreceptors Carotid artery Ischemia Vascular resistance |
title_short |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
title_full |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
title_fullStr |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
title_full_unstemmed |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
title_sort |
Changes in vascular resistance during carotid occlusion in normal and baroreceptor-denervated rats |
author |
Machado, Benedito H. |
author_facet |
Machado, Benedito H. Bonagamba, Leni G. H. Castania, Jaci A. Menani, José V. [UNESP] |
author_role |
author |
author2 |
Bonagamba, Leni G. H. Castania, Jaci A. Menani, José V. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
University of Sāo Paulo Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Machado, Benedito H. Bonagamba, Leni G. H. Castania, Jaci A. Menani, José V. [UNESP] |
dc.subject.por.fl_str_mv |
Baroreceptors Carotid artery Ischemia Vascular resistance |
topic |
Baroreceptors Carotid artery Ischemia Vascular resistance |
description |
In the present study, we investigated changes in mesenteric, renal, and hindquarter vascular resistance during the pressor response produced by bilateral carotid occlusion (BCO) in conscious, freely moving normal and denervated (aortic, carotid, or both) rats. BCO was performed using special previously implanted cuffs. In control normal rats, the increase in mean arterial pressure (MAP) during early and late responses (37±4 and 21 ±2 mm Hg, respectively) was related to increased renal (125±12% and 45±10%) and mesenteric (38±13% and 41±5%) but not hindquarter (14±4% and 8±7%) vascular resistance. In aortic-denervated rats, the greater MAP increase in early and late responses (57±4 and 44±4 mm Hg, respectively) compared with normal rats was related to a marked increase in hindquarter (137±26% and 106±26%) and mesenteric (104±14% and 66±9%) vascular resistance. In carotid-denervated rats, MAP increase and change in vascular resistance were similar to those values observed in control rats. Sinoaortic-denervated rats showed a greater MAP increase (34±4 mm Hg) during late response and a reduced increase in renal vascular resistance (46±6%) during early response. The present results show that 1) the pressor response to BCO in normal rats is associated with an increase in renal and mesenteric vascular resistance, 2) the aortic baroreceptors buffer the increase in mesenteric and especially hindquarter vascular resistance during BCO, and 3) the reduced pressor response in late response is probably related to a reduced increase in renal vascular resistance during this component compared with the early response. © 1992 American Heart Association, Inc. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-01-01 2022-04-28T19:53:52Z 2022-04-28T19:53:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1161/01.hyp.19.2_suppl.ii149 Hypertension, v. 19, n. 2, p. II-149-II-153, 1992. 1524-4563 0194-911X http://hdl.handle.net/11449/223935 10.1161/01.hyp.19.2_suppl.ii149 2-s2.0-0026563590 |
url |
http://dx.doi.org/10.1161/01.hyp.19.2_suppl.ii149 http://hdl.handle.net/11449/223935 |
identifier_str_mv |
Hypertension, v. 19, n. 2, p. II-149-II-153, 1992. 1524-4563 0194-911X 10.1161/01.hyp.19.2_suppl.ii149 2-s2.0-0026563590 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hypertension |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
II-149-II-153 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965013212921856 |