Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves

Detalhes bibliográficos
Autor(a) principal: Silva, D. G. [UNESP]
Data de Publicação: 2010
Outros Autores: Silva, P. R. L. [UNESP], Fagliari, J. J. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?pid=S0102-09352010000300001&script=sci_arttext
http://hdl.handle.net/11449/40676
Resumo: The efficacy of florfenicol associated or not to intravenous fluid therapy for treatment of Salmonella Dublin-infected calves was determined. Twenty-four healthy 10 to 15-day-old Holstein calves were randomly allotted into four groups, with six animals each: control (group 1); infected with 10(8)CFU Salmonella Dublin and not treated (group 2); infected with 10(8)CFU Salmonella Dublin and treated with florfenicol (group 3); and infected with 10(8)CFU Salmonella Dublin and treated with florfenicol associated to fluid therapy (group 4). All animals were submitted to physical examination just before inoculation and every 24 hours, during seven days after experimental infection. Rectal swabs and blood samples were collected for Salmonella Dublin isolation and pH and blood electrolytes determination. The experimental infection with Salmonella Dublin induced clinical signs of salmonellosis, such as diarrhea and fever, and caused reduction in blood concentrations of pH, sodium, potassium and chlorides. The treated calves showed good clinical recovery, and the group treated with antibiotic in combination to fluid therapy presented a faster and more efficient correction of the hydro-electrolyte balance.
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spelling Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calvesEficácia do florfenicol e da fluidoterapia parenteral no tratamento da salmonelose experimental em bezerros neonatosCalfSalmonella Dublinflorfenicollactated Ringer's solutionThe efficacy of florfenicol associated or not to intravenous fluid therapy for treatment of Salmonella Dublin-infected calves was determined. Twenty-four healthy 10 to 15-day-old Holstein calves were randomly allotted into four groups, with six animals each: control (group 1); infected with 10(8)CFU Salmonella Dublin and not treated (group 2); infected with 10(8)CFU Salmonella Dublin and treated with florfenicol (group 3); and infected with 10(8)CFU Salmonella Dublin and treated with florfenicol associated to fluid therapy (group 4). All animals were submitted to physical examination just before inoculation and every 24 hours, during seven days after experimental infection. Rectal swabs and blood samples were collected for Salmonella Dublin isolation and pH and blood electrolytes determination. The experimental infection with Salmonella Dublin induced clinical signs of salmonellosis, such as diarrhea and fever, and caused reduction in blood concentrations of pH, sodium, potassium and chlorides. The treated calves showed good clinical recovery, and the group treated with antibiotic in combination to fluid therapy presented a faster and more efficient correction of the hydro-electrolyte balance.Avaliou-se a eficácia terapêutica do florfenicol associado ou não à fluidoterapia intravenosa no tratamento de bezerros infectados experimentalmente com Salmonella Dublin. Foram utilizados 24 bezerros sadios da raça Holandesa com 10 a 15 dias de idade, distribuídos aleatoriamente em quatro grupos experimentais, constituídos por seis animais cada: controle (grupo 1); infectado com 108UFC de Salmonella Dublin e não tratado (grupo 2); infectado com 108UFC de Salmonella Dublin e tratado com florfenicol (grupo 3); e infectado com 108UFC de Salmonella Dublin (grupo 4) e tratado com florfenicol associado à fluidoterapia. Todos os animais foram submetidos ao exame físico logo antes da inoculação e a cada 24 horas, durante sete dias após a infecção experimental. Foram colhidas amostras de suabes retais para o isolamento de Salmonella Dublin e amostras de sangue para determinação dos valores de pH e dosagem de eletrólitos sanguíneos. A infecção experimental com Salmonella Dublin induziu sinais clínicos de salmonelose, como diarreia e febre, e provocou redução do valor do pH e das concentrações sanguíneas de sódio, potássio e cloreto. Os bezerros submetidos aos tratamentos mostraram boa recuperação clínica, sendo que o grupo tratado com antibiótico combinado à fluidoterapia apresentou correção mais rápida e eficiente do equilíbrio hidroeletrolítico.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP, Fac Ciencias Agr & Vet, DCCV, BR-14884900 Jaboticabal, SP, BrazilUNESP, Fac Ciencias Agr & Vet, DCCV, BR-14884900 Jaboticabal, SP, BrazilArquivo Brasileiro Medicina Veterinaria ZootecniaUniversidade Estadual Paulista (Unesp)Silva, D. G. [UNESP]Silva, P. R. L. [UNESP]Fagliari, J. J. [UNESP]2014-05-20T15:31:35Z2014-05-20T15:31:35Z2010-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article499-503application/pdfhttp://www.scielo.br/scielo.php?pid=S0102-09352010000300001&script=sci_arttextArquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 62, n. 3, p. 499-503, 2010.0102-0935http://hdl.handle.net/11449/40676S0102-09352010000300001WOS:000283991200001S0102-09352010000300001-en.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinária e Zootecnia0.2860,248info:eu-repo/semantics/openAccess2024-06-06T14:09:54Zoai:repositorio.unesp.br:11449/40676Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:23:04.520609Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
Eficácia do florfenicol e da fluidoterapia parenteral no tratamento da salmonelose experimental em bezerros neonatos
title Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
spellingShingle Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
Silva, D. G. [UNESP]
Calf
Salmonella Dublin
florfenicol
lactated Ringer's solution
title_short Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
title_full Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
title_fullStr Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
title_full_unstemmed Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
title_sort Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves
author Silva, D. G. [UNESP]
author_facet Silva, D. G. [UNESP]
Silva, P. R. L. [UNESP]
Fagliari, J. J. [UNESP]
author_role author
author2 Silva, P. R. L. [UNESP]
Fagliari, J. J. [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Silva, D. G. [UNESP]
Silva, P. R. L. [UNESP]
Fagliari, J. J. [UNESP]
dc.subject.por.fl_str_mv Calf
Salmonella Dublin
florfenicol
lactated Ringer's solution
topic Calf
Salmonella Dublin
florfenicol
lactated Ringer's solution
description The efficacy of florfenicol associated or not to intravenous fluid therapy for treatment of Salmonella Dublin-infected calves was determined. Twenty-four healthy 10 to 15-day-old Holstein calves were randomly allotted into four groups, with six animals each: control (group 1); infected with 10(8)CFU Salmonella Dublin and not treated (group 2); infected with 10(8)CFU Salmonella Dublin and treated with florfenicol (group 3); and infected with 10(8)CFU Salmonella Dublin and treated with florfenicol associated to fluid therapy (group 4). All animals were submitted to physical examination just before inoculation and every 24 hours, during seven days after experimental infection. Rectal swabs and blood samples were collected for Salmonella Dublin isolation and pH and blood electrolytes determination. The experimental infection with Salmonella Dublin induced clinical signs of salmonellosis, such as diarrhea and fever, and caused reduction in blood concentrations of pH, sodium, potassium and chlorides. The treated calves showed good clinical recovery, and the group treated with antibiotic in combination to fluid therapy presented a faster and more efficient correction of the hydro-electrolyte balance.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
2014-05-20T15:31:35Z
2014-05-20T15:31:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?pid=S0102-09352010000300001&script=sci_arttext
Arquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 62, n. 3, p. 499-503, 2010.
0102-0935
http://hdl.handle.net/11449/40676
S0102-09352010000300001
WOS:000283991200001
S0102-09352010000300001-en.pdf
url http://www.scielo.br/scielo.php?pid=S0102-09352010000300001&script=sci_arttext
http://hdl.handle.net/11449/40676
identifier_str_mv Arquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 62, n. 3, p. 499-503, 2010.
0102-0935
S0102-09352010000300001
WOS:000283991200001
S0102-09352010000300001-en.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia
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dc.format.none.fl_str_mv 499-503
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dc.publisher.none.fl_str_mv Arquivo Brasileiro Medicina Veterinaria Zootecnia
publisher.none.fl_str_mv Arquivo Brasileiro Medicina Veterinaria Zootecnia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
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