HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients

• Autor(a) principal: Bertol, Bruna Cristina
• Data de Publicação: 2020
• Outros Autores: Dias, Fabricio Cesar, Debortoli, Guilherme, Souto, Bruno Mendes, Mendonca, Priscila Baptista, Araujo, Roberta Chaves, Santana, Rodrigo Carvalho, Zambelli Ramalho, Leandra Naira, Castelli, Erick Cruz [UNESP], Candolo Martinelli, Ana de Lourdes, Mendes-Junior, Celso Teixeira, Carosella, Edgardo Delfino, Donadi, Eduardo Antonio, Moreau, Philippe
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1016/j.clim.2020.108482
• Texto Completo: http://dx.doi.org/10.1016/j.clim.2020.108482; http://hdl.handle.net/11449/197077
• topic: Human leukocyte antigen-G; Soluble HLA-G; HLA-G polymorphisms; HCV/HIV-coinfection; Antiviral immunity

Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplo-types differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups.