Functional consequences of lead and mercury exposomes in the heart
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.mam.2021.101048 http://hdl.handle.net/11449/222852 |
Resumo: | Lead and mercury are heavy metals that are highly toxic to life forms. There are no known physiological processes that require them, and they do not have a particular threshold concentration to produce biologic damage. They are non-biodegradable, and they slowly accumulate in the environment in a dynamic equilibrium between air, water, soil, food, and living organisms. Their accumulation in the environment has been increasing over time, because they were not banned from use in anthropogenic industrial production. In their +2 cationic state they are powerful oxidizing agents with the ability to interfere significantly with processes that require specific divalent cations. Acute or chronic exposure to lead and mercury can produce multisystemic damage, especially in the developing nervous systems of children and fetuses, resulting in variety of neurological consequences. They can also affect the cardiovascular system and especially the heart, either directly through their action on cardiomyocytes or indirectly through their effects on innervation, humoral responses or blood vessel alterations. For example, heart function modified by these heavy metals are heart rate, contraction, excitability, and rhythm. Some cardiac molecular targets have been identified and characterized. The direct mechanisms of damage of these heavy metals on heart function are discussed. We conclude that exposome to these heavy metals, should be considered as a major relevant risk factor for cardiac diseases. |
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Functional consequences of lead and mercury exposomes in the heartCardiacExposureIntoxicationLeadMercuryPoisoningLead and mercury are heavy metals that are highly toxic to life forms. There are no known physiological processes that require them, and they do not have a particular threshold concentration to produce biologic damage. They are non-biodegradable, and they slowly accumulate in the environment in a dynamic equilibrium between air, water, soil, food, and living organisms. Their accumulation in the environment has been increasing over time, because they were not banned from use in anthropogenic industrial production. In their +2 cationic state they are powerful oxidizing agents with the ability to interfere significantly with processes that require specific divalent cations. Acute or chronic exposure to lead and mercury can produce multisystemic damage, especially in the developing nervous systems of children and fetuses, resulting in variety of neurological consequences. They can also affect the cardiovascular system and especially the heart, either directly through their action on cardiomyocytes or indirectly through their effects on innervation, humoral responses or blood vessel alterations. For example, heart function modified by these heavy metals are heart rate, contraction, excitability, and rhythm. Some cardiac molecular targets have been identified and characterized. The direct mechanisms of damage of these heavy metals on heart function are discussed. We conclude that exposome to these heavy metals, should be considered as a major relevant risk factor for cardiac diseases.Agencia Nacional de Investigación e InnovaciónCA TechnologiesComisión Sectorial de Investigación CientíficaFondo Nacional de Desarrollo Científico y TecnológicoFP7 International CooperationRijksuniversiteit GroningenUniversity of South AlabamaLaboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la República, Gral. Flores, CP 11800Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology Universidad Católica de Chile, 8330024Department of Physiology Faculty of Pharmacy Universidad de SevillaMedical School (Faculty of Medicine) São Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland, QLD 4029Department of Pathology and Medical Biology University of Groningen University Medical Center GroningenDepartment of Molecular Pathology The Institute for Molecular Medicine, 16731 Gothard St. Huntington BeachMedical School (Faculty of Medicine) São Paulo State University (UNESP)Universidad de la RepúblicaUniversidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandThe Institute for Molecular MedicineFerreira, GonzaloSantander, AxelChavarría, LuisinaCardozo, RominaSavio, FlorenciaSobrevia, Luis [UNESP]Nicolson, Garth L.2022-04-28T19:47:09Z2022-04-28T19:47:09Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.mam.2021.101048Molecular Aspects of Medicine.1872-94520098-2997http://hdl.handle.net/11449/22285210.1016/j.mam.2021.1010482-s2.0-85118995260Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecular Aspects of Medicineinfo:eu-repo/semantics/openAccess2022-04-28T19:47:09Zoai:repositorio.unesp.br:11449/222852Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:50:16.687522Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Functional consequences of lead and mercury exposomes in the heart |
title |
Functional consequences of lead and mercury exposomes in the heart |
spellingShingle |
Functional consequences of lead and mercury exposomes in the heart Ferreira, Gonzalo Cardiac Exposure Intoxication Lead Mercury Poisoning |
title_short |
Functional consequences of lead and mercury exposomes in the heart |
title_full |
Functional consequences of lead and mercury exposomes in the heart |
title_fullStr |
Functional consequences of lead and mercury exposomes in the heart |
title_full_unstemmed |
Functional consequences of lead and mercury exposomes in the heart |
title_sort |
Functional consequences of lead and mercury exposomes in the heart |
author |
Ferreira, Gonzalo |
author_facet |
Ferreira, Gonzalo Santander, Axel Chavarría, Luisina Cardozo, Romina Savio, Florencia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author_role |
author |
author2 |
Santander, Axel Chavarría, Luisina Cardozo, Romina Savio, Florencia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidad de la República Universidad Católica de Chile Universidad de Sevilla Universidade Estadual Paulista (UNESP) University of Queensland The Institute for Molecular Medicine |
dc.contributor.author.fl_str_mv |
Ferreira, Gonzalo Santander, Axel Chavarría, Luisina Cardozo, Romina Savio, Florencia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
dc.subject.por.fl_str_mv |
Cardiac Exposure Intoxication Lead Mercury Poisoning |
topic |
Cardiac Exposure Intoxication Lead Mercury Poisoning |
description |
Lead and mercury are heavy metals that are highly toxic to life forms. There are no known physiological processes that require them, and they do not have a particular threshold concentration to produce biologic damage. They are non-biodegradable, and they slowly accumulate in the environment in a dynamic equilibrium between air, water, soil, food, and living organisms. Their accumulation in the environment has been increasing over time, because they were not banned from use in anthropogenic industrial production. In their +2 cationic state they are powerful oxidizing agents with the ability to interfere significantly with processes that require specific divalent cations. Acute or chronic exposure to lead and mercury can produce multisystemic damage, especially in the developing nervous systems of children and fetuses, resulting in variety of neurological consequences. They can also affect the cardiovascular system and especially the heart, either directly through their action on cardiomyocytes or indirectly through their effects on innervation, humoral responses or blood vessel alterations. For example, heart function modified by these heavy metals are heart rate, contraction, excitability, and rhythm. Some cardiac molecular targets have been identified and characterized. The direct mechanisms of damage of these heavy metals on heart function are discussed. We conclude that exposome to these heavy metals, should be considered as a major relevant risk factor for cardiac diseases. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:47:09Z 2022-04-28T19:47:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.mam.2021.101048 Molecular Aspects of Medicine. 1872-9452 0098-2997 http://hdl.handle.net/11449/222852 10.1016/j.mam.2021.101048 2-s2.0-85118995260 |
url |
http://dx.doi.org/10.1016/j.mam.2021.101048 http://hdl.handle.net/11449/222852 |
identifier_str_mv |
Molecular Aspects of Medicine. 1872-9452 0098-2997 10.1016/j.mam.2021.101048 2-s2.0-85118995260 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular Aspects of Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128281705185280 |