At1 receptor blockade improves myocardial functional performance in obesity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.36660/abc.20190131 http://hdl.handle.net/11449/201155 |
Resumo: | Background: Obesity has been associated with chronic activation of the renin-angiotensin-aldosterone system and with significant changes in cardiac performance. Objective: To assess the impact of a blockade of angiotensin-II receptor type 1 (AT1 receptor) on morphology and on myocardial functional performance in rats with high-fat diet-induced obesity. Methods: Wistar rats (n=48) were submitted to control (2.9 kcal/g) or high-fat (3.6 kcal/g) diet for 20 weeks. After the 16th week they were divided into four groups: Control (CO), Obese (OB), Control Losartan (CL) and Obese Losartan (OL). CL and OL received losartan (30 mg/kg/day) in drinking water for four weeks. Subsequently, body composition, systolic blood pressure (SBP) and echocardiographic variables were analyzed. Papillary muscle function was assessed at baseline with 2.50 mM calcium concentration ([Ca2+] ) and after inotropic maneuvers: post-pause potentiation (PPP), [Ca2+]o elevation, and during beta-adrenergic stimulationo with isoproterenol. Analysis of the results was performed by the Two-Way ANOVA and by the appropriate comparison test. The level of significance was set at 5%. Results: Although SBP change had been not maintained at the end of the experiment, obesity was associated with cardiac hypertrophy and with increased left ventricle posterior wall shortening velocity. In the study of papillary muscles in basal condition, CL showed lower developed tension maximum negative variation velocity (-dT/dt) than CO. The 60s PPP promoted lower-dT/dt and maximum developed tension (DT) in OB and CL compared with CO, and higher relative DT variation and maximum positive variation velocity (+dT/dt) in OL compared with CL and OB. Under 1.5, 2.0, and 2.5mM [Ca2+]o, the OL group showed higher-dT/dt than CL. Conclusion: Losartan improves myocardial function in high-fat diet-induced obesity. |
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At1 receptor blockade improves myocardial functional performance in obesityBloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na ObesidadeAngiotensin II Type 1 Receptor Blockers/ therapeutic useCardiovascular DiseasesDiet, High-fat/methodsLosartan/therapeutic useObesityRatsBackground: Obesity has been associated with chronic activation of the renin-angiotensin-aldosterone system and with significant changes in cardiac performance. Objective: To assess the impact of a blockade of angiotensin-II receptor type 1 (AT1 receptor) on morphology and on myocardial functional performance in rats with high-fat diet-induced obesity. Methods: Wistar rats (n=48) were submitted to control (2.9 kcal/g) or high-fat (3.6 kcal/g) diet for 20 weeks. After the 16th week they were divided into four groups: Control (CO), Obese (OB), Control Losartan (CL) and Obese Losartan (OL). CL and OL received losartan (30 mg/kg/day) in drinking water for four weeks. Subsequently, body composition, systolic blood pressure (SBP) and echocardiographic variables were analyzed. Papillary muscle function was assessed at baseline with 2.50 mM calcium concentration ([Ca2+] ) and after inotropic maneuvers: post-pause potentiation (PPP), [Ca2+]o elevation, and during beta-adrenergic stimulationo with isoproterenol. Analysis of the results was performed by the Two-Way ANOVA and by the appropriate comparison test. The level of significance was set at 5%. Results: Although SBP change had been not maintained at the end of the experiment, obesity was associated with cardiac hypertrophy and with increased left ventricle posterior wall shortening velocity. In the study of papillary muscles in basal condition, CL showed lower developed tension maximum negative variation velocity (-dT/dt) than CO. The 60s PPP promoted lower-dT/dt and maximum developed tension (DT) in OB and CL compared with CO, and higher relative DT variation and maximum positive variation velocity (+dT/dt) in OL compared with CL and OB. Under 1.5, 2.0, and 2.5mM [Ca2+]o, the OL group showed higher-dT/dt than CL. Conclusion: Losartan improves myocardial function in high-fat diet-induced obesity.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Mato Grosso do SulFaculdade de Medicina de Botucatu – UNESPFaculdade de Ciências Sociais e Agrárias de Itapeva (FAIT)Universidade Estadual de São Paulo (UNESP) Departamento de Medicina InternaUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina, Campus de BotucatuFaculdade de Medicina de Botucatu – UNESPUniversidade Estadual de São Paulo (UNESP) Departamento de Medicina InternaUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina, Campus de BotucatuCAPES: 001CNPq: 422776/2016-5Universidade Federal de Mato Grosso do Sul (UFMS)Universidade Estadual Paulista (Unesp)Faculdade de Ciências Sociais e Agrárias de Itapeva (FAIT)de Oliveira-Junior, Silvio AssisMuzili, Nayara de AraújoCarvalho, Marianna Rabelo deOta, Gabriel Eliasde Morais, Camila SouzaVieira, Larissa Fregapani da CostaOrtiz, Mateus OliveiraCampos, Dijon H. S. [UNESP]Cezar, Marcelo Diacardia Mariano [UNESP]Okoshi, Marina Politi [UNESP]Okoshi, Katashi [UNESP]Cicogna, Antonio C. [UNESP]Martinez, Paula Felippe2020-12-12T02:25:29Z2020-12-12T02:25:29Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17-28application/pdfhttp://dx.doi.org/10.36660/abc.20190131Arquivos Brasileiros de Cardiologia, v. 115, n. 1, p. 17-28, 2020.1678-41700066-782Xhttp://hdl.handle.net/11449/20115510.36660/abc.20190131S0066-782X20200008000172-s2.0-85089409957S0066-782X2020000800017.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccess2023-11-12T06:14:04Zoai:repositorio.unesp.br:11449/201155Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:30:18.341919Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
At1 receptor blockade improves myocardial functional performance in obesity Bloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na Obesidade |
title |
At1 receptor blockade improves myocardial functional performance in obesity |
spellingShingle |
At1 receptor blockade improves myocardial functional performance in obesity de Oliveira-Junior, Silvio Assis Angiotensin II Type 1 Receptor Blockers/ therapeutic use Cardiovascular Diseases Diet, High-fat/methods Losartan/therapeutic use Obesity Rats |
title_short |
At1 receptor blockade improves myocardial functional performance in obesity |
title_full |
At1 receptor blockade improves myocardial functional performance in obesity |
title_fullStr |
At1 receptor blockade improves myocardial functional performance in obesity |
title_full_unstemmed |
At1 receptor blockade improves myocardial functional performance in obesity |
title_sort |
At1 receptor blockade improves myocardial functional performance in obesity |
author |
de Oliveira-Junior, Silvio Assis |
author_facet |
de Oliveira-Junior, Silvio Assis Muzili, Nayara de Araújo Carvalho, Marianna Rabelo de Ota, Gabriel Elias de Morais, Camila Souza Vieira, Larissa Fregapani da Costa Ortiz, Mateus Oliveira Campos, Dijon H. S. [UNESP] Cezar, Marcelo Diacardia Mariano [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio C. [UNESP] Martinez, Paula Felippe |
author_role |
author |
author2 |
Muzili, Nayara de Araújo Carvalho, Marianna Rabelo de Ota, Gabriel Elias de Morais, Camila Souza Vieira, Larissa Fregapani da Costa Ortiz, Mateus Oliveira Campos, Dijon H. S. [UNESP] Cezar, Marcelo Diacardia Mariano [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio C. [UNESP] Martinez, Paula Felippe |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade Estadual Paulista (Unesp) Faculdade de Ciências Sociais e Agrárias de Itapeva (FAIT) |
dc.contributor.author.fl_str_mv |
de Oliveira-Junior, Silvio Assis Muzili, Nayara de Araújo Carvalho, Marianna Rabelo de Ota, Gabriel Elias de Morais, Camila Souza Vieira, Larissa Fregapani da Costa Ortiz, Mateus Oliveira Campos, Dijon H. S. [UNESP] Cezar, Marcelo Diacardia Mariano [UNESP] Okoshi, Marina Politi [UNESP] Okoshi, Katashi [UNESP] Cicogna, Antonio C. [UNESP] Martinez, Paula Felippe |
dc.subject.por.fl_str_mv |
Angiotensin II Type 1 Receptor Blockers/ therapeutic use Cardiovascular Diseases Diet, High-fat/methods Losartan/therapeutic use Obesity Rats |
topic |
Angiotensin II Type 1 Receptor Blockers/ therapeutic use Cardiovascular Diseases Diet, High-fat/methods Losartan/therapeutic use Obesity Rats |
description |
Background: Obesity has been associated with chronic activation of the renin-angiotensin-aldosterone system and with significant changes in cardiac performance. Objective: To assess the impact of a blockade of angiotensin-II receptor type 1 (AT1 receptor) on morphology and on myocardial functional performance in rats with high-fat diet-induced obesity. Methods: Wistar rats (n=48) were submitted to control (2.9 kcal/g) or high-fat (3.6 kcal/g) diet for 20 weeks. After the 16th week they were divided into four groups: Control (CO), Obese (OB), Control Losartan (CL) and Obese Losartan (OL). CL and OL received losartan (30 mg/kg/day) in drinking water for four weeks. Subsequently, body composition, systolic blood pressure (SBP) and echocardiographic variables were analyzed. Papillary muscle function was assessed at baseline with 2.50 mM calcium concentration ([Ca2+] ) and after inotropic maneuvers: post-pause potentiation (PPP), [Ca2+]o elevation, and during beta-adrenergic stimulationo with isoproterenol. Analysis of the results was performed by the Two-Way ANOVA and by the appropriate comparison test. The level of significance was set at 5%. Results: Although SBP change had been not maintained at the end of the experiment, obesity was associated with cardiac hypertrophy and with increased left ventricle posterior wall shortening velocity. In the study of papillary muscles in basal condition, CL showed lower developed tension maximum negative variation velocity (-dT/dt) than CO. The 60s PPP promoted lower-dT/dt and maximum developed tension (DT) in OB and CL compared with CO, and higher relative DT variation and maximum positive variation velocity (+dT/dt) in OL compared with CL and OB. Under 1.5, 2.0, and 2.5mM [Ca2+]o, the OL group showed higher-dT/dt than CL. Conclusion: Losartan improves myocardial function in high-fat diet-induced obesity. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:25:29Z 2020-12-12T02:25:29Z 2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.36660/abc.20190131 Arquivos Brasileiros de Cardiologia, v. 115, n. 1, p. 17-28, 2020. 1678-4170 0066-782X http://hdl.handle.net/11449/201155 10.36660/abc.20190131 S0066-782X2020000800017 2-s2.0-85089409957 S0066-782X2020000800017.pdf |
url |
http://dx.doi.org/10.36660/abc.20190131 http://hdl.handle.net/11449/201155 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 115, n. 1, p. 17-28, 2020. 1678-4170 0066-782X 10.36660/abc.20190131 S0066-782X2020000800017 2-s2.0-85089409957 S0066-782X2020000800017.pdf |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17-28 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128818772180992 |