Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-4162-10738 http://hdl.handle.net/11449/195283 |
Resumo: | Fipronil is a selective-toxicity insecticide widely used in agriculture and veterinary medicine. However, there are reports of neurotoxic effects of this substance, causing damages to vertebrates. We evaluated the locomotor activity, motor coordination and the activity of brain acetylcholinesterase in rats exposed to fipronil. Adult male Wistar rats (n=15) received fipronil at a dose of 30mg/kg orally for 15 days; the Control group (n=15) was treated with oral solution in the same period. On the 16th day of experimentation, the animals were submitted to the open field arena test and hole-board test. On the 17th day, they were anesthetized and euthanized, and organs were collected, and subsequently brain AChE was evaluated. Exposure to fipronil yielded no significant changes on motor coordination and locomotor activity but caused significant inhibition of brain acetylcholinesterase activity. These findings suggest that fipronil may cause short-term neurotoxic effects, which may be exacerbated if exposure is prolonged. |
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Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronilpesticidesphenylpyralozesneurotoxicityopen field testhole-board testFipronil is a selective-toxicity insecticide widely used in agriculture and veterinary medicine. However, there are reports of neurotoxic effects of this substance, causing damages to vertebrates. We evaluated the locomotor activity, motor coordination and the activity of brain acetylcholinesterase in rats exposed to fipronil. Adult male Wistar rats (n=15) received fipronil at a dose of 30mg/kg orally for 15 days; the Control group (n=15) was treated with oral solution in the same period. On the 16th day of experimentation, the animals were submitted to the open field arena test and hole-board test. On the 17th day, they were anesthetized and euthanized, and organs were collected, and subsequently brain AChE was evaluated. Exposure to fipronil yielded no significant changes on motor coordination and locomotor activity but caused significant inhibition of brain acetylcholinesterase activity. These findings suggest that fipronil may cause short-term neurotoxic effects, which may be exacerbated if exposure is prolonged.Univ Fed Rural Pernambuco, Recife, PE, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Botucatu, SP, BrazilArquivo Brasileiro Medicina Veterinaria ZootecniaUniv Fed Rural PernambucoUniversidade Estadual Paulista (Unesp)Barretto, M. L. M.Horta, D. F. [UNESP]Anselmo, F. [UNESP]Godinho, A. F. [UNESP]Oliveira, A. A. F.2020-12-10T17:29:28Z2020-12-10T17:29:28Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article169-176application/pdfhttp://dx.doi.org/10.1590/1678-4162-10738Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 1, p. 169-176, 2020.0102-0935http://hdl.handle.net/11449/19528310.1590/1678-4162-10738S0102-09352020000100169WOS:000523556000024S0102-09352020000100169.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivo Brasileiro De Medicina Veterinaria E Zootecniainfo:eu-repo/semantics/openAccess2023-12-07T06:17:00Zoai:repositorio.unesp.br:11449/195283Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:42:01.831062Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
title |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
spellingShingle |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil Barretto, M. L. M. pesticides phenylpyralozes neurotoxicity open field test hole-board test |
title_short |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
title_full |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
title_fullStr |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
title_full_unstemmed |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
title_sort |
Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil |
author |
Barretto, M. L. M. |
author_facet |
Barretto, M. L. M. Horta, D. F. [UNESP] Anselmo, F. [UNESP] Godinho, A. F. [UNESP] Oliveira, A. A. F. |
author_role |
author |
author2 |
Horta, D. F. [UNESP] Anselmo, F. [UNESP] Godinho, A. F. [UNESP] Oliveira, A. A. F. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Rural Pernambuco Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Barretto, M. L. M. Horta, D. F. [UNESP] Anselmo, F. [UNESP] Godinho, A. F. [UNESP] Oliveira, A. A. F. |
dc.subject.por.fl_str_mv |
pesticides phenylpyralozes neurotoxicity open field test hole-board test |
topic |
pesticides phenylpyralozes neurotoxicity open field test hole-board test |
description |
Fipronil is a selective-toxicity insecticide widely used in agriculture and veterinary medicine. However, there are reports of neurotoxic effects of this substance, causing damages to vertebrates. We evaluated the locomotor activity, motor coordination and the activity of brain acetylcholinesterase in rats exposed to fipronil. Adult male Wistar rats (n=15) received fipronil at a dose of 30mg/kg orally for 15 days; the Control group (n=15) was treated with oral solution in the same period. On the 16th day of experimentation, the animals were submitted to the open field arena test and hole-board test. On the 17th day, they were anesthetized and euthanized, and organs were collected, and subsequently brain AChE was evaluated. Exposure to fipronil yielded no significant changes on motor coordination and locomotor activity but caused significant inhibition of brain acetylcholinesterase activity. These findings suggest that fipronil may cause short-term neurotoxic effects, which may be exacerbated if exposure is prolonged. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T17:29:28Z 2020-12-10T17:29:28Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-4162-10738 Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 1, p. 169-176, 2020. 0102-0935 http://hdl.handle.net/11449/195283 10.1590/1678-4162-10738 S0102-09352020000100169 WOS:000523556000024 S0102-09352020000100169.pdf |
url |
http://dx.doi.org/10.1590/1678-4162-10738 http://hdl.handle.net/11449/195283 |
identifier_str_mv |
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 1, p. 169-176, 2020. 0102-0935 10.1590/1678-4162-10738 S0102-09352020000100169 WOS:000523556000024 S0102-09352020000100169.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
169-176 application/pdf |
dc.publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129107124289536 |