Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1414-431X2022e12409 http://hdl.handle.net/11449/248111 |
Resumo: | The common epidermal growth factor receptor (EGFR) mutations, such as the L858R point mutation in exon 21 and the in-frame deletional mutation in exon 19, have been definitively associated with response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). However, the clinical outcome and response to treatment for many other rarer mutations are still unclear. In this study, we report the results of Brazilian patients in stage IB–IIIA non-small cell lung cancer (NSCLC) following complete resection with minimal residual disease and EGFR mutations treated with adjuvant chemotherapy and/or EGFR-TKIs. The frequency of EGFR mutations was investigated in 70 cases of early stage NSCLC. Mutations in exons 18 and 20, uncommon mutations in exons 19 and 21, as well as in exons 3, 7, 14, 16, 22, 27, and 28, and/or the presence of different mutations in a single tumor (complex mutations) are considered rare. EGFR mutations were detected in 23 tumors (32.9%). Fourteen cases carried rare mutations and were treated with platinum-based chemotherapy and two cases were treated with erlotinib. The clinical outcome is described case by case with references to the literature. Notably, we found two rare EGFR mutations and one of them with an unknown response to chemotherapy and/or EGFR-TKIs. We have provided complementary information concerning the clinical outcome and treatment of patients with early stage NSCLC for several rare EGFR mutations not previously or only rarely reported. Description of cases harboring rare mutations can support the decision-making process in this subset of patients. |
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Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptorErlotinibLung cancerNext generation sequencingPlatinum-based chemotherapyRare EGFR mutationThe common epidermal growth factor receptor (EGFR) mutations, such as the L858R point mutation in exon 21 and the in-frame deletional mutation in exon 19, have been definitively associated with response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). However, the clinical outcome and response to treatment for many other rarer mutations are still unclear. In this study, we report the results of Brazilian patients in stage IB–IIIA non-small cell lung cancer (NSCLC) following complete resection with minimal residual disease and EGFR mutations treated with adjuvant chemotherapy and/or EGFR-TKIs. The frequency of EGFR mutations was investigated in 70 cases of early stage NSCLC. Mutations in exons 18 and 20, uncommon mutations in exons 19 and 21, as well as in exons 3, 7, 14, 16, 22, 27, and 28, and/or the presence of different mutations in a single tumor (complex mutations) are considered rare. EGFR mutations were detected in 23 tumors (32.9%). Fourteen cases carried rare mutations and were treated with platinum-based chemotherapy and two cases were treated with erlotinib. The clinical outcome is described case by case with references to the literature. Notably, we found two rare EGFR mutations and one of them with an unknown response to chemotherapy and/or EGFR-TKIs. We have provided complementary information concerning the clinical outcome and treatment of patients with early stage NSCLC for several rare EGFR mutations not previously or only rarely reported. Description of cases harboring rare mutations can support the decision-making process in this subset of patients.Laboratório de Histomorfometria e Genômica Pulmonar Departamento de Patologia Faculdade de Medicina Universidade de São Paulo, SPCentro de Avaliac¸ão de Tecnologias em Saúde Hospital das Clínicas de Botucatu Faculdade de Medicina Universidade Estadual Paulista, SPCentro Internacional de Pesquisa/CIPE AC Camargo Cancer Center, SPDepartamento de Patologia e Medicina Legal Laboratório de Medicina Respiratória Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SPInstituto de Biociências Departamento de Ciências Químicas e Biológicas Universidade Estadual Paulista, SPLaboratório de Genética Molecular e Bioinformática Unidade de Pesquisa Experimental Faculdade de Medicina Universidade Estadual Paulista, SPDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista, SPInstituto de Biotecnologia Universidade Estadual Paulista, SPInstituto de Biociências Departamento de Bioestatística Biologia Vegetal Parasitologia e Zoologia Universidade Estadual Paulista, SPDivisão de Pneumologia Instituto do Coracão Faculdade de Medicina Universidade de São Paulo, SPDepartamento de Radiologia e Oncologia Faculdade de Medicina Universidade de São Paulo, SPLaboratório de Genética Molecular Centro de Pesquisa Translacional em Oncologia Instituto do Câncer de São Paulo, SPCentro de Avaliac¸ão de Tecnologias em Saúde Hospital das Clínicas de Botucatu Faculdade de Medicina Universidade Estadual Paulista, SPInstituto de Biociências Departamento de Ciências Químicas e Biológicas Universidade Estadual Paulista, SPLaboratório de Genética Molecular e Bioinformática Unidade de Pesquisa Experimental Faculdade de Medicina Universidade Estadual Paulista, SPDepartamento de Patologia Faculdade de Medicina Universidade Estadual Paulista, SPInstituto de Biotecnologia Universidade Estadual Paulista, SPInstituto de Biociências Departamento de Bioestatística Biologia Vegetal Parasitologia e Zoologia Universidade Estadual Paulista, SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)AC Camargo Cancer CenterInstituto do Câncer de São PauloMachado-Rugolo, J. [UNESP]Baldavira, C. M.Prieto, T. G.Olivieri, E. H.R.Fabro, A. T.Rainho, C. A. [UNESP]Castelli, E. C. [UNESP]Ribolla, P. E.M. [UNESP]Ab’saber, A. M.Takagaki, T.Nagai, M. A.Capelozzi, V. L.2023-07-29T13:34:45Z2023-07-29T13:34:45Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1414-431X2022e12409Brazilian Journal of Medical and Biological Research, v. 55.1414-431Xhttp://hdl.handle.net/11449/24811110.1590/1414-431X2022e124092-s2.0-85145230049Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2023-07-29T13:34:45Zoai:repositorio.unesp.br:11449/248111Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:54:42.301659Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
title |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
spellingShingle |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor Machado-Rugolo, J. [UNESP] Erlotinib Lung cancer Next generation sequencing Platinum-based chemotherapy Rare EGFR mutation |
title_short |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
title_full |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
title_fullStr |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
title_full_unstemmed |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
title_sort |
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor |
author |
Machado-Rugolo, J. [UNESP] |
author_facet |
Machado-Rugolo, J. [UNESP] Baldavira, C. M. Prieto, T. G. Olivieri, E. H.R. Fabro, A. T. Rainho, C. A. [UNESP] Castelli, E. C. [UNESP] Ribolla, P. E.M. [UNESP] Ab’saber, A. M. Takagaki, T. Nagai, M. A. Capelozzi, V. L. |
author_role |
author |
author2 |
Baldavira, C. M. Prieto, T. G. Olivieri, E. H.R. Fabro, A. T. Rainho, C. A. [UNESP] Castelli, E. C. [UNESP] Ribolla, P. E.M. [UNESP] Ab’saber, A. M. Takagaki, T. Nagai, M. A. Capelozzi, V. L. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) AC Camargo Cancer Center Instituto do Câncer de São Paulo |
dc.contributor.author.fl_str_mv |
Machado-Rugolo, J. [UNESP] Baldavira, C. M. Prieto, T. G. Olivieri, E. H.R. Fabro, A. T. Rainho, C. A. [UNESP] Castelli, E. C. [UNESP] Ribolla, P. E.M. [UNESP] Ab’saber, A. M. Takagaki, T. Nagai, M. A. Capelozzi, V. L. |
dc.subject.por.fl_str_mv |
Erlotinib Lung cancer Next generation sequencing Platinum-based chemotherapy Rare EGFR mutation |
topic |
Erlotinib Lung cancer Next generation sequencing Platinum-based chemotherapy Rare EGFR mutation |
description |
The common epidermal growth factor receptor (EGFR) mutations, such as the L858R point mutation in exon 21 and the in-frame deletional mutation in exon 19, have been definitively associated with response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). However, the clinical outcome and response to treatment for many other rarer mutations are still unclear. In this study, we report the results of Brazilian patients in stage IB–IIIA non-small cell lung cancer (NSCLC) following complete resection with minimal residual disease and EGFR mutations treated with adjuvant chemotherapy and/or EGFR-TKIs. The frequency of EGFR mutations was investigated in 70 cases of early stage NSCLC. Mutations in exons 18 and 20, uncommon mutations in exons 19 and 21, as well as in exons 3, 7, 14, 16, 22, 27, and 28, and/or the presence of different mutations in a single tumor (complex mutations) are considered rare. EGFR mutations were detected in 23 tumors (32.9%). Fourteen cases carried rare mutations and were treated with platinum-based chemotherapy and two cases were treated with erlotinib. The clinical outcome is described case by case with references to the literature. Notably, we found two rare EGFR mutations and one of them with an unknown response to chemotherapy and/or EGFR-TKIs. We have provided complementary information concerning the clinical outcome and treatment of patients with early stage NSCLC for several rare EGFR mutations not previously or only rarely reported. Description of cases harboring rare mutations can support the decision-making process in this subset of patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:34:45Z 2023-07-29T13:34:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1414-431X2022e12409 Brazilian Journal of Medical and Biological Research, v. 55. 1414-431X http://hdl.handle.net/11449/248111 10.1590/1414-431X2022e12409 2-s2.0-85145230049 |
url |
http://dx.doi.org/10.1590/1414-431X2022e12409 http://hdl.handle.net/11449/248111 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 55. 1414-431X 10.1590/1414-431X2022e12409 2-s2.0-85145230049 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128719612542976 |