Achados clínicos, genéticos e microbiológicos de uma família com periodontite agressiva de Maceió

• Autor(a) principal: Sogumo, Patrícia Mayumi [UNESP]
• Data de Publicação: 2010
• Outros Autores: Cavalcante, Lícia Bezerra [UNESP], Finoti, Lívia Sertori [UNESP], Spolidorio, Denise Madalena Palomari [UNESP], Carlos Júnio, Amaro, lipinski-Figueiredo, Eneida, Pires, Juliana Rico, Scarel-Caminaga, Raquel Mantuaneli [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://revodontolunesp.com.br/article/51ae4aa61ef1faca3d003600; http://hdl.handle.net/11449/125834
• topic: Periodontitis; Microbiology; Genetics; Cytokines; Periodontite crônica; Microbiologia; Genética; Citocinas

The present study reports clinical, microbiological and genetic findings in members of a family with Aggressive Periodontitis (AgP) from Maceió - AL, Brazil. After periodontal exams in fourteen members of the family, DNA was obtained from epithelial buccal cells and microbiological samples were collected from subgingival plaque to detect five species of periodontopathogens by Polymerase Chain Reaction (PCR). PCR-RFLP (Restriction Fragment Length Polymorphism) was used to investigate human polymorphisms in interleukin genes (IL4, IL10). Six members of the family showed Generalized AgP and eight were considered unaffected by the AgP. There was no association of alleles, genotypes and haplotypes in the IL10 and IL4 genes with the AgP in the studied family. Treponema denticola (T.d.) was the prevalent pathogen, followed by the Tannerella forsythia (T.f.). There was correlation between clinical findings (clinical attachment loss, bleeding on probing and probing depth) with the presence of T.d., while T.f. was correlated with bleeding on probing. In conclusion, although the investigated polimorphisms were not associated with the susceptibility to AgP, the presence of periodontopathogens is related to worse periodontal clinical parameters.