Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1021/acsapm.2c00744 http://hdl.handle.net/11449/246025 |
Resumo: | The worldwide outbreak of the coronavirus pandemic (COVID-19) and other emerging infections are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. It is noteworthy that Ag-based semiconductors can help orchestrate several strategies to fight this serious societal issue. In this work, we present the synthesis of α-Ag2WO4, β-Ag2MoO4, and Ag2CrO4 and their immobilization in polypropylene in the amounts of 0.5, 1.0, and 3.0 wt %, respectively. The antimicrobial activity of the composites was investigated against the Gram-negative bacterium Escherichia coli, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans. The best antimicrobial efficiency was achieved by the composite with α-Ag2WO4, which completely eliminated the microorganisms in up to 4 h of exposure. The composites were also tested for the inhibition of SARS-CoV-2 virus, showing antiviral efficiency higher than 98% in just 10 min. Additionally, we evaluated the stability of the antimicrobial activity, resulting in constant inhibition, even after material aging. The antimicrobial activity of the compounds was attributed to the production of reactive oxygen species by the semiconductors, which can induce high local oxidative stress, causing the death of these microorganisms. |
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Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other PathogensAg2CrO4anti-SARS-CoV-2 materialantimicrobial materialcompositesα-Ag2WO4β-Ag2MoO4The worldwide outbreak of the coronavirus pandemic (COVID-19) and other emerging infections are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. It is noteworthy that Ag-based semiconductors can help orchestrate several strategies to fight this serious societal issue. In this work, we present the synthesis of α-Ag2WO4, β-Ag2MoO4, and Ag2CrO4 and their immobilization in polypropylene in the amounts of 0.5, 1.0, and 3.0 wt %, respectively. The antimicrobial activity of the composites was investigated against the Gram-negative bacterium Escherichia coli, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans. The best antimicrobial efficiency was achieved by the composite with α-Ag2WO4, which completely eliminated the microorganisms in up to 4 h of exposure. The composites were also tested for the inhibition of SARS-CoV-2 virus, showing antiviral efficiency higher than 98% in just 10 min. Additionally, we evaluated the stability of the antimicrobial activity, resulting in constant inhibition, even after material aging. The antimicrobial activity of the compounds was attributed to the production of reactive oxygen species by the semiconductors, which can induce high local oxidative stress, causing the death of these microorganisms.Department of Physical and Analytical Chemistry University Jaume i (UJI)Cdmf Liec Federal University of São Carlos - (UFSCar), SPBiomolecules and Microbiology Laboratory (LaMiB) Biotechnology Graduation Program (PPGBiotec) Federal University of São Carlos (UFSCar), SPChemistry Department Federal University of São Carlos (UFSCar), SPDepartment of Materials Engineering Federal University of São Carlos - (UFSCar), SPSchool of Agriculture São Paulo State University (Unesp), SPMolecular Laboratory of Clinical Hospital of Botucatu Medical School São Paulo State University (Unesp), SPSchool of Agriculture São Paulo State University (Unesp), SPMolecular Laboratory of Clinical Hospital of Botucatu Medical School São Paulo State University (Unesp), SPUniversity Jaume i (UJI)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Assis, MarceloRibeiro, Lara K.Gonçalves, Mariana O.Staffa, Lucas H.Paiva, Robert S.Lima, Lais R.Coelho, DyovaniAlmeida, Lauana F. [UNESP]Moraes, Leonardo N. [UNESP]Rosa, Ieda L. V.Mascaro, Lucia H.Grotto, Rejane M. T. [UNESP]Sousa, Cristina P.Andrés, JuanLongo, ElsonCruz, Sandra A.2023-07-29T12:29:44Z2023-07-29T12:29:44Z2022-10-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7102-7114http://dx.doi.org/10.1021/acsapm.2c00744ACS Applied Polymer Materials, v. 4, n. 10, p. 7102-7114, 2022.2637-6105http://hdl.handle.net/11449/24602510.1021/acsapm.2c007442-s2.0-85139369448Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengACS Applied Polymer Materialsinfo:eu-repo/semantics/openAccess2023-07-29T12:29:44Zoai:repositorio.unesp.br:11449/246025Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T12:29:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
title |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
spellingShingle |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens Assis, Marcelo Ag2CrO4 anti-SARS-CoV-2 material antimicrobial material composites α-Ag2WO4 β-Ag2MoO4 |
title_short |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
title_full |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
title_fullStr |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
title_full_unstemmed |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
title_sort |
Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens |
author |
Assis, Marcelo |
author_facet |
Assis, Marcelo Ribeiro, Lara K. Gonçalves, Mariana O. Staffa, Lucas H. Paiva, Robert S. Lima, Lais R. Coelho, Dyovani Almeida, Lauana F. [UNESP] Moraes, Leonardo N. [UNESP] Rosa, Ieda L. V. Mascaro, Lucia H. Grotto, Rejane M. T. [UNESP] Sousa, Cristina P. Andrés, Juan Longo, Elson Cruz, Sandra A. |
author_role |
author |
author2 |
Ribeiro, Lara K. Gonçalves, Mariana O. Staffa, Lucas H. Paiva, Robert S. Lima, Lais R. Coelho, Dyovani Almeida, Lauana F. [UNESP] Moraes, Leonardo N. [UNESP] Rosa, Ieda L. V. Mascaro, Lucia H. Grotto, Rejane M. T. [UNESP] Sousa, Cristina P. Andrés, Juan Longo, Elson Cruz, Sandra A. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University Jaume i (UJI) Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Assis, Marcelo Ribeiro, Lara K. Gonçalves, Mariana O. Staffa, Lucas H. Paiva, Robert S. Lima, Lais R. Coelho, Dyovani Almeida, Lauana F. [UNESP] Moraes, Leonardo N. [UNESP] Rosa, Ieda L. V. Mascaro, Lucia H. Grotto, Rejane M. T. [UNESP] Sousa, Cristina P. Andrés, Juan Longo, Elson Cruz, Sandra A. |
dc.subject.por.fl_str_mv |
Ag2CrO4 anti-SARS-CoV-2 material antimicrobial material composites α-Ag2WO4 β-Ag2MoO4 |
topic |
Ag2CrO4 anti-SARS-CoV-2 material antimicrobial material composites α-Ag2WO4 β-Ag2MoO4 |
description |
The worldwide outbreak of the coronavirus pandemic (COVID-19) and other emerging infections are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. It is noteworthy that Ag-based semiconductors can help orchestrate several strategies to fight this serious societal issue. In this work, we present the synthesis of α-Ag2WO4, β-Ag2MoO4, and Ag2CrO4 and their immobilization in polypropylene in the amounts of 0.5, 1.0, and 3.0 wt %, respectively. The antimicrobial activity of the composites was investigated against the Gram-negative bacterium Escherichia coli, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans. The best antimicrobial efficiency was achieved by the composite with α-Ag2WO4, which completely eliminated the microorganisms in up to 4 h of exposure. The composites were also tested for the inhibition of SARS-CoV-2 virus, showing antiviral efficiency higher than 98% in just 10 min. Additionally, we evaluated the stability of the antimicrobial activity, resulting in constant inhibition, even after material aging. The antimicrobial activity of the compounds was attributed to the production of reactive oxygen species by the semiconductors, which can induce high local oxidative stress, causing the death of these microorganisms. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-14 2023-07-29T12:29:44Z 2023-07-29T12:29:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1021/acsapm.2c00744 ACS Applied Polymer Materials, v. 4, n. 10, p. 7102-7114, 2022. 2637-6105 http://hdl.handle.net/11449/246025 10.1021/acsapm.2c00744 2-s2.0-85139369448 |
url |
http://dx.doi.org/10.1021/acsapm.2c00744 http://hdl.handle.net/11449/246025 |
identifier_str_mv |
ACS Applied Polymer Materials, v. 4, n. 10, p. 7102-7114, 2022. 2637-6105 10.1021/acsapm.2c00744 2-s2.0-85139369448 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ACS Applied Polymer Materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7102-7114 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046960455745536 |