Incidence of congenital malformations and impact on the mortality of neonatal canines
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.theriogenology.2019.07.027 http://hdl.handle.net/11449/189516 |
Resumo: | Canine congenital malformations are structural or functional abnormalities of organs present at birth that possibly interfere with the viability of newborns, thus contributing to neonatal mortality. This study evaluated and described the incidence of congenital malformations in neonatal dogs and determined the mortality rates among those affected. Of the 178 litters and 803 newborns included in the study, 24.7% (44/178) of the litters presented neonates with congenital malformations. The total rate of neonates that presented malformations was 6.7% (64/803). The total mortality rate in newborns with congenital defects was 5.4% (44/803), representing 68.7% (44/64) of the deaths observed among those affected. The early (0–2 days old) and late (3–30 days old) mortality rates among the affected neonates were 61.4% (27/44) and 38.6% (17/44), respectively. In total, 27 malformations were recorded, and the most common congenital defects were cleft palate 2.8% (23/803) and hydrocephaly 1.5% (12/803), either alone or associated with other malformations. The malformations were recorded in 15 breeds: Pug, Miniature Pinscher, Rottweiler, Pitbull, French Bulldog, English Bulldog, Dachshund, Labrador Retriever, Lhasa Apso, Poodle, German Spitz, Yorkshire Terrier, Shih-tzu, Brazilian Terrier and mixed breed. One case of exposure to a teratogenic agent was reported, but no maternal exposure to teratogens during gestation was reported with the other litters. The occurrence of congenital defects may be related to genetic factors since the highest incidence of malformations (84.4%) was observed in purebred dogs. |
id |
UNSP_fe3fc6dfbca6f536fea0d4e9166e7897 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/189516 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Incidence of congenital malformations and impact on the mortality of neonatal caninesCanine neonatologyCongenital defectsNewborn dogPuppyTeratogenesisCanine congenital malformations are structural or functional abnormalities of organs present at birth that possibly interfere with the viability of newborns, thus contributing to neonatal mortality. This study evaluated and described the incidence of congenital malformations in neonatal dogs and determined the mortality rates among those affected. Of the 178 litters and 803 newborns included in the study, 24.7% (44/178) of the litters presented neonates with congenital malformations. The total rate of neonates that presented malformations was 6.7% (64/803). The total mortality rate in newborns with congenital defects was 5.4% (44/803), representing 68.7% (44/64) of the deaths observed among those affected. The early (0–2 days old) and late (3–30 days old) mortality rates among the affected neonates were 61.4% (27/44) and 38.6% (17/44), respectively. In total, 27 malformations were recorded, and the most common congenital defects were cleft palate 2.8% (23/803) and hydrocephaly 1.5% (12/803), either alone or associated with other malformations. The malformations were recorded in 15 breeds: Pug, Miniature Pinscher, Rottweiler, Pitbull, French Bulldog, English Bulldog, Dachshund, Labrador Retriever, Lhasa Apso, Poodle, German Spitz, Yorkshire Terrier, Shih-tzu, Brazilian Terrier and mixed breed. One case of exposure to a teratogenic agent was reported, but no maternal exposure to teratogens during gestation was reported with the other litters. The occurrence of congenital defects may be related to genetic factors since the highest incidence of malformations (84.4%) was observed in purebred dogs.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Veterinary Clinics School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Animal Breeding and Nutrition School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Veterinary Anesthesiology and Surgery School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Veterinary Clinics School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Animal Breeding and Nutrition School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Veterinary Anesthesiology and Surgery School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Nobre Pacifico Pereira, Keylla Helena [UNESP]Cruz dos Santos Correia, Luiz Eduardo [UNESP]Ritir Oliveira, Elton Luís [UNESP]Bernardo, Ramona Bastos [UNESP]Nagib Jorge, Mariana Lemos [UNESP]Mezzena Gobato, Mariana Luiza [UNESP]Ferreira de Souza, Fabiana [UNESP]Rocha, Noeme Sousa [UNESP]Chiacchio, Simone Biagio [UNESP]Gomes Lourenço, Maria Lucia [UNESP]2019-10-06T16:43:12Z2019-10-06T16:43:12Z2019-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article52-57http://dx.doi.org/10.1016/j.theriogenology.2019.07.027Theriogenology, v. 140, p. 52-57.0093-691Xhttp://hdl.handle.net/11449/18951610.1016/j.theriogenology.2019.07.0272-s2.0-8507077904760777359184692840000-0002-8188-8149Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTheriogenologyinfo:eu-repo/semantics/openAccess2021-10-23T03:22:32Zoai:repositorio.unesp.br:11449/189516Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T03:22:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
title |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
spellingShingle |
Incidence of congenital malformations and impact on the mortality of neonatal canines Nobre Pacifico Pereira, Keylla Helena [UNESP] Canine neonatology Congenital defects Newborn dog Puppy Teratogenesis |
title_short |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
title_full |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
title_fullStr |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
title_full_unstemmed |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
title_sort |
Incidence of congenital malformations and impact on the mortality of neonatal canines |
author |
Nobre Pacifico Pereira, Keylla Helena [UNESP] |
author_facet |
Nobre Pacifico Pereira, Keylla Helena [UNESP] Cruz dos Santos Correia, Luiz Eduardo [UNESP] Ritir Oliveira, Elton Luís [UNESP] Bernardo, Ramona Bastos [UNESP] Nagib Jorge, Mariana Lemos [UNESP] Mezzena Gobato, Mariana Luiza [UNESP] Ferreira de Souza, Fabiana [UNESP] Rocha, Noeme Sousa [UNESP] Chiacchio, Simone Biagio [UNESP] Gomes Lourenço, Maria Lucia [UNESP] |
author_role |
author |
author2 |
Cruz dos Santos Correia, Luiz Eduardo [UNESP] Ritir Oliveira, Elton Luís [UNESP] Bernardo, Ramona Bastos [UNESP] Nagib Jorge, Mariana Lemos [UNESP] Mezzena Gobato, Mariana Luiza [UNESP] Ferreira de Souza, Fabiana [UNESP] Rocha, Noeme Sousa [UNESP] Chiacchio, Simone Biagio [UNESP] Gomes Lourenço, Maria Lucia [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nobre Pacifico Pereira, Keylla Helena [UNESP] Cruz dos Santos Correia, Luiz Eduardo [UNESP] Ritir Oliveira, Elton Luís [UNESP] Bernardo, Ramona Bastos [UNESP] Nagib Jorge, Mariana Lemos [UNESP] Mezzena Gobato, Mariana Luiza [UNESP] Ferreira de Souza, Fabiana [UNESP] Rocha, Noeme Sousa [UNESP] Chiacchio, Simone Biagio [UNESP] Gomes Lourenço, Maria Lucia [UNESP] |
dc.subject.por.fl_str_mv |
Canine neonatology Congenital defects Newborn dog Puppy Teratogenesis |
topic |
Canine neonatology Congenital defects Newborn dog Puppy Teratogenesis |
description |
Canine congenital malformations are structural or functional abnormalities of organs present at birth that possibly interfere with the viability of newborns, thus contributing to neonatal mortality. This study evaluated and described the incidence of congenital malformations in neonatal dogs and determined the mortality rates among those affected. Of the 178 litters and 803 newborns included in the study, 24.7% (44/178) of the litters presented neonates with congenital malformations. The total rate of neonates that presented malformations was 6.7% (64/803). The total mortality rate in newborns with congenital defects was 5.4% (44/803), representing 68.7% (44/64) of the deaths observed among those affected. The early (0–2 days old) and late (3–30 days old) mortality rates among the affected neonates were 61.4% (27/44) and 38.6% (17/44), respectively. In total, 27 malformations were recorded, and the most common congenital defects were cleft palate 2.8% (23/803) and hydrocephaly 1.5% (12/803), either alone or associated with other malformations. The malformations were recorded in 15 breeds: Pug, Miniature Pinscher, Rottweiler, Pitbull, French Bulldog, English Bulldog, Dachshund, Labrador Retriever, Lhasa Apso, Poodle, German Spitz, Yorkshire Terrier, Shih-tzu, Brazilian Terrier and mixed breed. One case of exposure to a teratogenic agent was reported, but no maternal exposure to teratogens during gestation was reported with the other litters. The occurrence of congenital defects may be related to genetic factors since the highest incidence of malformations (84.4%) was observed in purebred dogs. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:43:12Z 2019-10-06T16:43:12Z 2019-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.theriogenology.2019.07.027 Theriogenology, v. 140, p. 52-57. 0093-691X http://hdl.handle.net/11449/189516 10.1016/j.theriogenology.2019.07.027 2-s2.0-85070779047 6077735918469284 0000-0002-8188-8149 |
url |
http://dx.doi.org/10.1016/j.theriogenology.2019.07.027 http://hdl.handle.net/11449/189516 |
identifier_str_mv |
Theriogenology, v. 140, p. 52-57. 0093-691X 10.1016/j.theriogenology.2019.07.027 2-s2.0-85070779047 6077735918469284 0000-0002-8188-8149 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Theriogenology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
52-57 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047290446807040 |