The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release.
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/223929 |
Resumo: | The effect of tubero-infundibular dopaminergic neurons (TIDA) on the release of prolactin (PRL) and alpha-melanocyte stimulating hormone (alpha-MSH) was studied in median eminence-lesioned (MEL) male rats (N = 6-28). Plasma PRL and alpha-MSH levels were significantly elevated 2 (86.1 +/- 19.8 and 505.1 +/- 19.1 ng/ml), 4 (278.7 +/- 15.5 and 487.4 +/- 125.1 ng/ml), 7 (116.2 +/- 16.2 and 495.8 +/- 62.6 ng/ml) and 14 (247.3 +/- 26.1 and 448.4 +/- 63.8 ng/ml) days after MEL when compared to sham-operated control animals (55.5 +/- 13.4 and 56.2 +/- 6.1 ng/ml, respectively). MEL altered plasma PRL and alpha-MSH levels in a differential manner, with a 1.5- to 5.0-fold increase in PRL and an 8.0- to 9.0-fold increase in alpha-MSH. The increase of alpha-MSH levels occurred abruptly and remained constant from days 2 to 14. These observations indicate that TIDA plays an important role in the pituitary release of PRL and alpha-MSH and provide evidence that the release of the two hormones occurs in a differential manner. |
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The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release.The effect of tubero-infundibular dopaminergic neurons (TIDA) on the release of prolactin (PRL) and alpha-melanocyte stimulating hormone (alpha-MSH) was studied in median eminence-lesioned (MEL) male rats (N = 6-28). Plasma PRL and alpha-MSH levels were significantly elevated 2 (86.1 +/- 19.8 and 505.1 +/- 19.1 ng/ml), 4 (278.7 +/- 15.5 and 487.4 +/- 125.1 ng/ml), 7 (116.2 +/- 16.2 and 495.8 +/- 62.6 ng/ml) and 14 (247.3 +/- 26.1 and 448.4 +/- 63.8 ng/ml) days after MEL when compared to sham-operated control animals (55.5 +/- 13.4 and 56.2 +/- 6.1 ng/ml, respectively). MEL altered plasma PRL and alpha-MSH levels in a differential manner, with a 1.5- to 5.0-fold increase in PRL and an 8.0- to 9.0-fold increase in alpha-MSH. The increase of alpha-MSH levels occurred abruptly and remained constant from days 2 to 14. These observations indicate that TIDA plays an important role in the pituitary release of PRL and alpha-MSH and provide evidence that the release of the two hormones occurs in a differential manner.Departamento de Ciências Fisiológicas Faculdade de Odontologia de Araçatuba Universidade Estadual Paulista Araçatuba SPDepartamento de Ciências Fisiológicas Faculdade de Odontologia de Araçatuba Universidade Estadual Paulista Araçatuba SPUniversidade Estadual Paulista (UNESP)Bedran-de-Castro, J. C. [UNESP]Petrovic, S. L. [UNESP]Khorram, O. [UNESP]McCann, S. M. [UNESP]2022-04-28T19:53:51Z2022-04-28T19:53:51Z1991-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1059-1062Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 24, n. 10, p. 1059-1062, 1991.0100-879Xhttp://hdl.handle.net/11449/2239292-s2.0-0026300078Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]info:eu-repo/semantics/openAccess2022-04-28T19:53:51Zoai:repositorio.unesp.br:11449/223929Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:48:37.254565Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
title |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
spellingShingle |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. Bedran-de-Castro, J. C. [UNESP] |
title_short |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
title_full |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
title_fullStr |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
title_full_unstemmed |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
title_sort |
The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release. |
author |
Bedran-de-Castro, J. C. [UNESP] |
author_facet |
Bedran-de-Castro, J. C. [UNESP] Petrovic, S. L. [UNESP] Khorram, O. [UNESP] McCann, S. M. [UNESP] |
author_role |
author |
author2 |
Petrovic, S. L. [UNESP] Khorram, O. [UNESP] McCann, S. M. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Bedran-de-Castro, J. C. [UNESP] Petrovic, S. L. [UNESP] Khorram, O. [UNESP] McCann, S. M. [UNESP] |
description |
The effect of tubero-infundibular dopaminergic neurons (TIDA) on the release of prolactin (PRL) and alpha-melanocyte stimulating hormone (alpha-MSH) was studied in median eminence-lesioned (MEL) male rats (N = 6-28). Plasma PRL and alpha-MSH levels were significantly elevated 2 (86.1 +/- 19.8 and 505.1 +/- 19.1 ng/ml), 4 (278.7 +/- 15.5 and 487.4 +/- 125.1 ng/ml), 7 (116.2 +/- 16.2 and 495.8 +/- 62.6 ng/ml) and 14 (247.3 +/- 26.1 and 448.4 +/- 63.8 ng/ml) days after MEL when compared to sham-operated control animals (55.5 +/- 13.4 and 56.2 +/- 6.1 ng/ml, respectively). MEL altered plasma PRL and alpha-MSH levels in a differential manner, with a 1.5- to 5.0-fold increase in PRL and an 8.0- to 9.0-fold increase in alpha-MSH. The increase of alpha-MSH levels occurred abruptly and remained constant from days 2 to 14. These observations indicate that TIDA plays an important role in the pituitary release of PRL and alpha-MSH and provide evidence that the release of the two hormones occurs in a differential manner. |
publishDate |
1991 |
dc.date.none.fl_str_mv |
1991-01-01 2022-04-28T19:53:51Z 2022-04-28T19:53:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 24, n. 10, p. 1059-1062, 1991. 0100-879X http://hdl.handle.net/11449/223929 2-s2.0-0026300078 |
identifier_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 24, n. 10, p. 1059-1062, 1991. 0100-879X 2-s2.0-0026300078 |
url |
http://hdl.handle.net/11449/223929 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1059-1062 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129360194961408 |