Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sba.com.br/arquivos/revista/rba/jan99035.pdf http://hdl.handle.net/11449/65709 |
Resumo: | Background and Objectives. The analgesic actions of nonsteroidal anti-inflammatory drugs (NSAID) result from the inhibition of the peripheral synthesis of prostaglandins. In spite of the emphasis on the peripheral action, several studies have shown the potential central action of such drugs. In rats, NSAID doses insufficient to block pain when systemically administered were effective when intrathecally injected. This effect could be mediated by interaction with descending serotoninergic ways together with neurotransmission modulation of glycine or N-methyl-D-aspartate receptors. Our goal was to study the effect of different tenoxican doses in the histology of dogs spinal cord and meninges. Methods. Thirty two dogs (7 to 17 kg) were randomly distributed in four groups: G1 - Control with distilled water (DW); G2 - 2 mg tenoxican diluted in DW; G3 - 4 mg tenoxican diluted in DW; G4 - 10 mg tenoxican diluted in DW in a constant volume of 1 ml. Anesthesia was induced with etomidate and fentanyl and dural puncture was performed with a 25G spinal needle in interspace L6-7. Animals were observed for 72 hours and subsequently euthanized by electrocution. Lumbar and sacral spinal cord segments were removed for further histologic examination. Results. All animals were clinically normal during the observation period and there has been no histologic alteration of the nervous system and meninges. Conclusions. In our experimental model intrathecal tenoxican doses up to 10 mg have not triggered nervous tissue or meningeal injuries in dogs. |
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Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caesEffects of different doses of tenoxicam on spinal cord and meninges. Experimental study in dogsAnesthetic techniques: regional, spinal blockAnimal: dogAnti-inflammatory: tenoxicanetomidatefentanylglycinen methyl dextro aspartic acid receptornonsteroid antiinflammatory agentprostaglandintenoxicamanesthesiaanimal experimentanimal modelanimal tissuecontrolled studydogfemalehistologyintrathecal drug administrationlumbar puncturelumbar spinal cordmalemeninxneurotransmissionnonhumanprostaglandin synthesis inhibitionratsacral spinal cordserotoninergic systemspinal cordBackground and Objectives. The analgesic actions of nonsteroidal anti-inflammatory drugs (NSAID) result from the inhibition of the peripheral synthesis of prostaglandins. In spite of the emphasis on the peripheral action, several studies have shown the potential central action of such drugs. In rats, NSAID doses insufficient to block pain when systemically administered were effective when intrathecally injected. This effect could be mediated by interaction with descending serotoninergic ways together with neurotransmission modulation of glycine or N-methyl-D-aspartate receptors. Our goal was to study the effect of different tenoxican doses in the histology of dogs spinal cord and meninges. Methods. Thirty two dogs (7 to 17 kg) were randomly distributed in four groups: G1 - Control with distilled water (DW); G2 - 2 mg tenoxican diluted in DW; G3 - 4 mg tenoxican diluted in DW; G4 - 10 mg tenoxican diluted in DW in a constant volume of 1 ml. Anesthesia was induced with etomidate and fentanyl and dural puncture was performed with a 25G spinal needle in interspace L6-7. Animals were observed for 72 hours and subsequently euthanized by electrocution. Lumbar and sacral spinal cord segments were removed for further histologic examination. Results. All animals were clinically normal during the observation period and there has been no histologic alteration of the nervous system and meninges. Conclusions. In our experimental model intrathecal tenoxican doses up to 10 mg have not triggered nervous tissue or meningeal injuries in dogs.Departamento de Anestesiologia FMB-UNESP, Caixa Postal 530, 18618-000 Botucatu, SPDepartamento de Anestesiologia FMB-UNESP, Caixa Postal 530, 18618-000 Botucatu, SPUniversidade Estadual Paulista (Unesp)Ganem, Eliana Marisa [UNESP]Vianna, Pedro Thadeu Galvão [UNESP]Castiglia, Yara Marcondes Machado [UNESP]Braz, José Reinaldo Cerqueira [UNESP]Do Nascimento, P. [UNESP]Vanne, L. A. [UNESP]2014-05-27T11:19:42Z2014-05-27T11:19:42Z1999-01-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article35-37application/pdfhttp://www.sba.com.br/arquivos/revista/rba/jan99035.pdfRevista Brasileira de Anestesiologia, v. 49, n. 1, p. 35-37, 1999.0034-7094http://hdl.handle.net/11449/657092-s2.0-00328928282-s2.0-0032892828.pdf8226942130768820Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Anestesiologia0.8500,320info:eu-repo/semantics/openAccess2024-08-14T13:20:25Zoai:repositorio.unesp.br:11449/65709Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:20:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes Effects of different doses of tenoxicam on spinal cord and meninges. Experimental study in dogs |
title |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
spellingShingle |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes Ganem, Eliana Marisa [UNESP] Anesthetic techniques: regional, spinal block Animal: dog Anti-inflammatory: tenoxican etomidate fentanyl glycine n methyl dextro aspartic acid receptor nonsteroid antiinflammatory agent prostaglandin tenoxicam anesthesia animal experiment animal model animal tissue controlled study dog female histology intrathecal drug administration lumbar puncture lumbar spinal cord male meninx neurotransmission nonhuman prostaglandin synthesis inhibition rat sacral spinal cord serotoninergic system spinal cord |
title_short |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
title_full |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
title_fullStr |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
title_full_unstemmed |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
title_sort |
Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes |
author |
Ganem, Eliana Marisa [UNESP] |
author_facet |
Ganem, Eliana Marisa [UNESP] Vianna, Pedro Thadeu Galvão [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Braz, José Reinaldo Cerqueira [UNESP] Do Nascimento, P. [UNESP] Vanne, L. A. [UNESP] |
author_role |
author |
author2 |
Vianna, Pedro Thadeu Galvão [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Braz, José Reinaldo Cerqueira [UNESP] Do Nascimento, P. [UNESP] Vanne, L. A. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ganem, Eliana Marisa [UNESP] Vianna, Pedro Thadeu Galvão [UNESP] Castiglia, Yara Marcondes Machado [UNESP] Braz, José Reinaldo Cerqueira [UNESP] Do Nascimento, P. [UNESP] Vanne, L. A. [UNESP] |
dc.subject.por.fl_str_mv |
Anesthetic techniques: regional, spinal block Animal: dog Anti-inflammatory: tenoxican etomidate fentanyl glycine n methyl dextro aspartic acid receptor nonsteroid antiinflammatory agent prostaglandin tenoxicam anesthesia animal experiment animal model animal tissue controlled study dog female histology intrathecal drug administration lumbar puncture lumbar spinal cord male meninx neurotransmission nonhuman prostaglandin synthesis inhibition rat sacral spinal cord serotoninergic system spinal cord |
topic |
Anesthetic techniques: regional, spinal block Animal: dog Anti-inflammatory: tenoxican etomidate fentanyl glycine n methyl dextro aspartic acid receptor nonsteroid antiinflammatory agent prostaglandin tenoxicam anesthesia animal experiment animal model animal tissue controlled study dog female histology intrathecal drug administration lumbar puncture lumbar spinal cord male meninx neurotransmission nonhuman prostaglandin synthesis inhibition rat sacral spinal cord serotoninergic system spinal cord |
description |
Background and Objectives. The analgesic actions of nonsteroidal anti-inflammatory drugs (NSAID) result from the inhibition of the peripheral synthesis of prostaglandins. In spite of the emphasis on the peripheral action, several studies have shown the potential central action of such drugs. In rats, NSAID doses insufficient to block pain when systemically administered were effective when intrathecally injected. This effect could be mediated by interaction with descending serotoninergic ways together with neurotransmission modulation of glycine or N-methyl-D-aspartate receptors. Our goal was to study the effect of different tenoxican doses in the histology of dogs spinal cord and meninges. Methods. Thirty two dogs (7 to 17 kg) were randomly distributed in four groups: G1 - Control with distilled water (DW); G2 - 2 mg tenoxican diluted in DW; G3 - 4 mg tenoxican diluted in DW; G4 - 10 mg tenoxican diluted in DW in a constant volume of 1 ml. Anesthesia was induced with etomidate and fentanyl and dural puncture was performed with a 25G spinal needle in interspace L6-7. Animals were observed for 72 hours and subsequently euthanized by electrocution. Lumbar and sacral spinal cord segments were removed for further histologic examination. Results. All animals were clinically normal during the observation period and there has been no histologic alteration of the nervous system and meninges. Conclusions. In our experimental model intrathecal tenoxican doses up to 10 mg have not triggered nervous tissue or meningeal injuries in dogs. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-01-27 2014-05-27T11:19:42Z 2014-05-27T11:19:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sba.com.br/arquivos/revista/rba/jan99035.pdf Revista Brasileira de Anestesiologia, v. 49, n. 1, p. 35-37, 1999. 0034-7094 http://hdl.handle.net/11449/65709 2-s2.0-0032892828 2-s2.0-0032892828.pdf 8226942130768820 |
url |
http://www.sba.com.br/arquivos/revista/rba/jan99035.pdf http://hdl.handle.net/11449/65709 |
identifier_str_mv |
Revista Brasileira de Anestesiologia, v. 49, n. 1, p. 35-37, 1999. 0034-7094 2-s2.0-0032892828 2-s2.0-0032892828.pdf 8226942130768820 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Anestesiologia 0.850 0,320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
35-37 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128134709510144 |