Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.vetpar.2023.109918 http://hdl.handle.net/11449/249845 |
Resumo: | Nanoformulations containing zein nanoparticles (ZN) can promote the stability and protection of molecules with acaricidal activity. The present study sought to develop nanoformulations with ZN associated with cypermethrin (CYPE) + chlorpyrifos (CHLO) + a plant compound (citral, menthol or limonene), characterize them, and verify their efficacy against Rhipicephalus microplus ticks. Additionally, we aimed to assess its safety in nontarget nematodes found in soil at a site subjected to contamination by acaricides. The nanoformulations were characterized by dynamic light scattering and nanoparticle tracking analysis. Nanoformulations 1 (ZN+CYPE+CHLO+citral), 2 (ZN+CYPE+CHLO+menthol), and 3 (ZN+CYPE+CHLO+limonene) were measured for diameter, polydispersion, zeta potential, concentration, and encapsulation efficiency. Nanoformulations 1, 2, and 3 were evaluated in a range from 0.004 to 0.466 mg/mL on R. microplus larvae and caused mortality > 80% at concentrations above 0.029 mg/mL. The commercial acaricide Colosso® (CYPE 15 g + CHLO 25 g + citronellal 1 g) was evaluated also from 0.004 to 0.512 mg/mL and resulted in 71.9% larval mortality at 0.064 mg/mL. Formulations 1, 2, and 3 at 0.466 mg/mL showed acaricidal efficacy of 50.2%, 40.5%, and 60.1% on engorged females, respectively, while Colosso® at 0.512 mg/mL obtained only 39.4%. The nanoformulations exhibited long residual period of activity and lower toxicity to nontarget nematodes. ZN was able to protect the active compounds against degradation during the storage period. Thus, ZN can be an alternative for the development of new acaricidal formulations using lower concentrations of active compounds. |
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Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplusAcaricide residuesNanocarrierNanoformulationsResistanceTick controlNanoformulations containing zein nanoparticles (ZN) can promote the stability and protection of molecules with acaricidal activity. The present study sought to develop nanoformulations with ZN associated with cypermethrin (CYPE) + chlorpyrifos (CHLO) + a plant compound (citral, menthol or limonene), characterize them, and verify their efficacy against Rhipicephalus microplus ticks. Additionally, we aimed to assess its safety in nontarget nematodes found in soil at a site subjected to contamination by acaricides. The nanoformulations were characterized by dynamic light scattering and nanoparticle tracking analysis. Nanoformulations 1 (ZN+CYPE+CHLO+citral), 2 (ZN+CYPE+CHLO+menthol), and 3 (ZN+CYPE+CHLO+limonene) were measured for diameter, polydispersion, zeta potential, concentration, and encapsulation efficiency. Nanoformulations 1, 2, and 3 were evaluated in a range from 0.004 to 0.466 mg/mL on R. microplus larvae and caused mortality > 80% at concentrations above 0.029 mg/mL. The commercial acaricide Colosso® (CYPE 15 g + CHLO 25 g + citronellal 1 g) was evaluated also from 0.004 to 0.512 mg/mL and resulted in 71.9% larval mortality at 0.064 mg/mL. Formulations 1, 2, and 3 at 0.466 mg/mL showed acaricidal efficacy of 50.2%, 40.5%, and 60.1% on engorged females, respectively, while Colosso® at 0.512 mg/mL obtained only 39.4%. The nanoformulations exhibited long residual period of activity and lower toxicity to nontarget nematodes. ZN was able to protect the active compounds against degradation during the storage period. Thus, ZN can be an alternative for the development of new acaricidal formulations using lower concentrations of active compounds.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Empresa Brasileira de Pesquisa AgropecuáriaFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual PaulistaSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), Rod. Prof. Paulo Donato Castellane, SPBrazilian Agricultural Research Corporation (EMBRAPA) Southeast Livestock Unit, Rod. Washington Luiz, Km 234 s/n, Fazenda Canchim, SPInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, SPSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú, km 1, Campos Ville, SPLaboratory of Biochemistry and Toxicology in Caenorhabditis elegans Federal University of Pampa, BR 472, Km 592, RSSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), Rod. Prof. Paulo Donato Castellane, SPInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, SPSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú, km 1, Campos Ville, SPCNPq: 169777/2017-0Empresa Brasileira de Pesquisa Agropecuária: 20.18.03.17.00-02FAPESP: 2016/06784-1, 2017/21004-5, 2017/13249-8FAPESP: 2018/16070-1FAPESP: 2019/20185-1Universidade Estadual Paulista: 88882.434504/2019-01Universidade Estadual Paulista (UNESP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Federal University of PampaFigueiredo, Amanda [UNESP]Anholeto, Luís AdrianoCola, Diego Faria [UNESP]Fantatto, Rafaela Regina [UNESP]Gainza, Yousmel Alemán [UNESP]dos Santos, Isabella Barbosa [UNESP]Viçozzi, Gabriel PedrosoÁvila, Daiana SilvaFraceto, Leonardo Fernandes [UNESP]Chagas, Ana Carolina de Souza2023-07-29T16:10:48Z2023-07-29T16:10:48Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.vetpar.2023.109918Veterinary Parasitology, v. 318.1873-25500304-4017http://hdl.handle.net/11449/24984510.1016/j.vetpar.2023.1099182-s2.0-85152097988Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Parasitologyinfo:eu-repo/semantics/openAccess2023-07-29T16:10:48Zoai:repositorio.unesp.br:11449/249845Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:04:10.631461Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
title |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
spellingShingle |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus Figueiredo, Amanda [UNESP] Acaricide residues Nanocarrier Nanoformulations Resistance Tick control |
title_short |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
title_full |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
title_fullStr |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
title_full_unstemmed |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
title_sort |
Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus |
author |
Figueiredo, Amanda [UNESP] |
author_facet |
Figueiredo, Amanda [UNESP] Anholeto, Luís Adriano Cola, Diego Faria [UNESP] Fantatto, Rafaela Regina [UNESP] Gainza, Yousmel Alemán [UNESP] dos Santos, Isabella Barbosa [UNESP] Viçozzi, Gabriel Pedroso Ávila, Daiana Silva Fraceto, Leonardo Fernandes [UNESP] Chagas, Ana Carolina de Souza |
author_role |
author |
author2 |
Anholeto, Luís Adriano Cola, Diego Faria [UNESP] Fantatto, Rafaela Regina [UNESP] Gainza, Yousmel Alemán [UNESP] dos Santos, Isabella Barbosa [UNESP] Viçozzi, Gabriel Pedroso Ávila, Daiana Silva Fraceto, Leonardo Fernandes [UNESP] Chagas, Ana Carolina de Souza |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Federal University of Pampa |
dc.contributor.author.fl_str_mv |
Figueiredo, Amanda [UNESP] Anholeto, Luís Adriano Cola, Diego Faria [UNESP] Fantatto, Rafaela Regina [UNESP] Gainza, Yousmel Alemán [UNESP] dos Santos, Isabella Barbosa [UNESP] Viçozzi, Gabriel Pedroso Ávila, Daiana Silva Fraceto, Leonardo Fernandes [UNESP] Chagas, Ana Carolina de Souza |
dc.subject.por.fl_str_mv |
Acaricide residues Nanocarrier Nanoformulations Resistance Tick control |
topic |
Acaricide residues Nanocarrier Nanoformulations Resistance Tick control |
description |
Nanoformulations containing zein nanoparticles (ZN) can promote the stability and protection of molecules with acaricidal activity. The present study sought to develop nanoformulations with ZN associated with cypermethrin (CYPE) + chlorpyrifos (CHLO) + a plant compound (citral, menthol or limonene), characterize them, and verify their efficacy against Rhipicephalus microplus ticks. Additionally, we aimed to assess its safety in nontarget nematodes found in soil at a site subjected to contamination by acaricides. The nanoformulations were characterized by dynamic light scattering and nanoparticle tracking analysis. Nanoformulations 1 (ZN+CYPE+CHLO+citral), 2 (ZN+CYPE+CHLO+menthol), and 3 (ZN+CYPE+CHLO+limonene) were measured for diameter, polydispersion, zeta potential, concentration, and encapsulation efficiency. Nanoformulations 1, 2, and 3 were evaluated in a range from 0.004 to 0.466 mg/mL on R. microplus larvae and caused mortality > 80% at concentrations above 0.029 mg/mL. The commercial acaricide Colosso® (CYPE 15 g + CHLO 25 g + citronellal 1 g) was evaluated also from 0.004 to 0.512 mg/mL and resulted in 71.9% larval mortality at 0.064 mg/mL. Formulations 1, 2, and 3 at 0.466 mg/mL showed acaricidal efficacy of 50.2%, 40.5%, and 60.1% on engorged females, respectively, while Colosso® at 0.512 mg/mL obtained only 39.4%. The nanoformulations exhibited long residual period of activity and lower toxicity to nontarget nematodes. ZN was able to protect the active compounds against degradation during the storage period. Thus, ZN can be an alternative for the development of new acaricidal formulations using lower concentrations of active compounds. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:10:48Z 2023-07-29T16:10:48Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.vetpar.2023.109918 Veterinary Parasitology, v. 318. 1873-2550 0304-4017 http://hdl.handle.net/11449/249845 10.1016/j.vetpar.2023.109918 2-s2.0-85152097988 |
url |
http://dx.doi.org/10.1016/j.vetpar.2023.109918 http://hdl.handle.net/11449/249845 |
identifier_str_mv |
Veterinary Parasitology, v. 318. 1873-2550 0304-4017 10.1016/j.vetpar.2023.109918 2-s2.0-85152097988 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Parasitology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129487238332416 |