Genome-wide scan reveals genomic regions and candidate genes underlying direct and maternal effects of preweaning calf mortality in Nellore cattle

• Autor(a) principal: Marín-Garzón, N. A. [UNESP]
• Data de Publicação: 2021
• Outros Autores: Magalhães, A. F.B. [UNESP], Schmidt, P. I. [UNESP], Serna, M. [UNESP], Fonseca, L. F.S. [UNESP], Salatta, B. M. [UNESP], Frezarim, G. B. [UNESP], Fernandes-Júnior, G. A. [UNESP], Bresolin, T. [UNESP], Carvalheiro, R. [UNESP], Albuquerque, L. G. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.ygeno.2021.02.021; http://hdl.handle.net/11449/208515
• topic: Beef cattle; Complex traits; Gene interaction network; Heritability; Single-step GWAS; Survival

We conducted analysis to estimate genetic parameters and to identify genomic regions and candidate genes affecting direct and maternal effects of preweaning calf mortality (PWM) in Nellore cattle. Phenotypic records of 67,196 animals, and 8443 genotypes for 410,936 SNPs were used. Analysis were performed through the weighted single-step GBLUP approach and considering a threshold animal model via Bayesian Inference. Direct and maternal heritability estimates were of 0.2143 ± 0.0348 and 0.0137 ± 0.0066, respectively. The top 10 genomic regions accounted for 13.61 and 14.23% of the direct and maternal additive genetic variances and harbored a total of 63 and 91 positional candidate genes, respectively. Two overlapping regions on BTA2 were identified for both direct and maternal effects. Candidate genes are involved in biological mechanisms i.e. embryogenesis, immune response, feto-maternal communication, circadian rhythm, hormone alterations, myometrium adaptation, and milk secretion, which are critical for the successful calf growth and survival during preweaning period.