Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/plants11223115 http://hdl.handle.net/11449/246372 |
Resumo: | Verbena officinalis L. or vervain is an herbal medicine and dietary supplement used worldwide. It is used for antidepressant and anticonvulsant purposes, as well as to treat inflammatory disorders, skin burns, abrasions, and gastric diseases, among others. Here, we investigated the biochemical, antioxidant, and histopathological effects of vervain against chronic physical stress. Male Wistar rats were submitted to chronic physical training and oral administration of 200 mg/kg of extract for 7 weeks. Control animals were not treated with either stress or vervain. Body weight was monitored during the study. Liver, kidney, spleen, testis, epididymis, heart, skeletal muscle, and brain samples were collected. Blood cholesterol, lactate dehydrogenase (LDH), bilirubin, and creatinine kinase (CREA), among others, were studied. Glutathione peroxidase (GPox) and superoxide dismutase (SOD) antioxidant activity was analyzed in the blood, liver, and kidney. Testosterone measurements were also performed on whole testis extracts. We found significant weight ratios differences in the epididymis, brain, and heart. Animals submitted to training showed hemorrhagic livers. Kidney histology was affected by both stress and vervain. Cell disruption and vacuolization were observed in the testes and epididymis of animals submitted to stress. Hematological and biochemical markers as CREA, LDH, TP, CKI, URCA, γGT, and glucose revealed statistically significantly differences. Additionally, the activity of glutathione peroxide (GPox) and superoxide dismutase (SOD) in the blood was also impacted. Both stress and vervain have significant in vivo effects. Infusions of vervain include phenylpropanoids, iridoids, verbenalin, hastatoside, and flavonoids, amongst others, which interact synergistically to produce the preclinical effects reported here. |
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Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parametersclinical toxicologycommon vervainexercise trainingoxidative stressVerbena officinalisLVerbena officinalis L. or vervain is an herbal medicine and dietary supplement used worldwide. It is used for antidepressant and anticonvulsant purposes, as well as to treat inflammatory disorders, skin burns, abrasions, and gastric diseases, among others. Here, we investigated the biochemical, antioxidant, and histopathological effects of vervain against chronic physical stress. Male Wistar rats were submitted to chronic physical training and oral administration of 200 mg/kg of extract for 7 weeks. Control animals were not treated with either stress or vervain. Body weight was monitored during the study. Liver, kidney, spleen, testis, epididymis, heart, skeletal muscle, and brain samples were collected. Blood cholesterol, lactate dehydrogenase (LDH), bilirubin, and creatinine kinase (CREA), among others, were studied. Glutathione peroxidase (GPox) and superoxide dismutase (SOD) antioxidant activity was analyzed in the blood, liver, and kidney. Testosterone measurements were also performed on whole testis extracts. We found significant weight ratios differences in the epididymis, brain, and heart. Animals submitted to training showed hemorrhagic livers. Kidney histology was affected by both stress and vervain. Cell disruption and vacuolization were observed in the testes and epididymis of animals submitted to stress. Hematological and biochemical markers as CREA, LDH, TP, CKI, URCA, γGT, and glucose revealed statistically significantly differences. Additionally, the activity of glutathione peroxide (GPox) and superoxide dismutase (SOD) in the blood was also impacted. Both stress and vervain have significant in vivo effects. Infusions of vervain include phenylpropanoids, iridoids, verbenalin, hastatoside, and flavonoids, amongst others, which interact synergistically to produce the preclinical effects reported here.Centro de Estudos Ambientais e Marinhos, Universidade de AveiroCICECO-Aveiro Institute of Materials University of AveiroHunter Medical Research Institute, New Lambton HeightsHospital Center of Baixo VougaPadre Albino University Centre, São PauloInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), São PauloDepartment of Biology & CESAM Centre for Environmental and Marine Studies University of AveiroDepartment of Medical Sciences University of AveiroInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), São PauloUniversity of AveiroHunter Medical Research InstituteHospital Center of Baixo VougaPadre Albino University CentreUniversidade Estadual Paulista (UNESP)Rodrigues Oliveira, Sonia M.Dias, ElsaGirol, Ana Paula [UNESP]Silva, HelenaPereira, Maria de Lourdes2023-07-29T12:39:07Z2023-07-29T12:39:07Z2022-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/plants11223115Plants, v. 11, n. 22, 2022.2223-7747http://hdl.handle.net/11449/24637210.3390/plants112231152-s2.0-85142663209Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlantsinfo:eu-repo/semantics/openAccess2023-07-29T12:39:07Zoai:repositorio.unesp.br:11449/246372Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:18:11.094647Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
title |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
spellingShingle |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters Rodrigues Oliveira, Sonia M. clinical toxicology common vervain exercise training oxidative stress Verbena officinalisL |
title_short |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
title_full |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
title_fullStr |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
title_full_unstemmed |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
title_sort |
Exercise Training and Verbena officinalis L. Affect Pre-Clinical and Histological Parameters |
author |
Rodrigues Oliveira, Sonia M. |
author_facet |
Rodrigues Oliveira, Sonia M. Dias, Elsa Girol, Ana Paula [UNESP] Silva, Helena Pereira, Maria de Lourdes |
author_role |
author |
author2 |
Dias, Elsa Girol, Ana Paula [UNESP] Silva, Helena Pereira, Maria de Lourdes |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
University of Aveiro Hunter Medical Research Institute Hospital Center of Baixo Vouga Padre Albino University Centre Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Rodrigues Oliveira, Sonia M. Dias, Elsa Girol, Ana Paula [UNESP] Silva, Helena Pereira, Maria de Lourdes |
dc.subject.por.fl_str_mv |
clinical toxicology common vervain exercise training oxidative stress Verbena officinalisL |
topic |
clinical toxicology common vervain exercise training oxidative stress Verbena officinalisL |
description |
Verbena officinalis L. or vervain is an herbal medicine and dietary supplement used worldwide. It is used for antidepressant and anticonvulsant purposes, as well as to treat inflammatory disorders, skin burns, abrasions, and gastric diseases, among others. Here, we investigated the biochemical, antioxidant, and histopathological effects of vervain against chronic physical stress. Male Wistar rats were submitted to chronic physical training and oral administration of 200 mg/kg of extract for 7 weeks. Control animals were not treated with either stress or vervain. Body weight was monitored during the study. Liver, kidney, spleen, testis, epididymis, heart, skeletal muscle, and brain samples were collected. Blood cholesterol, lactate dehydrogenase (LDH), bilirubin, and creatinine kinase (CREA), among others, were studied. Glutathione peroxidase (GPox) and superoxide dismutase (SOD) antioxidant activity was analyzed in the blood, liver, and kidney. Testosterone measurements were also performed on whole testis extracts. We found significant weight ratios differences in the epididymis, brain, and heart. Animals submitted to training showed hemorrhagic livers. Kidney histology was affected by both stress and vervain. Cell disruption and vacuolization were observed in the testes and epididymis of animals submitted to stress. Hematological and biochemical markers as CREA, LDH, TP, CKI, URCA, γGT, and glucose revealed statistically significantly differences. Additionally, the activity of glutathione peroxide (GPox) and superoxide dismutase (SOD) in the blood was also impacted. Both stress and vervain have significant in vivo effects. Infusions of vervain include phenylpropanoids, iridoids, verbenalin, hastatoside, and flavonoids, amongst others, which interact synergistically to produce the preclinical effects reported here. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-01 2023-07-29T12:39:07Z 2023-07-29T12:39:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/plants11223115 Plants, v. 11, n. 22, 2022. 2223-7747 http://hdl.handle.net/11449/246372 10.3390/plants11223115 2-s2.0-85142663209 |
url |
http://dx.doi.org/10.3390/plants11223115 http://hdl.handle.net/11449/246372 |
identifier_str_mv |
Plants, v. 11, n. 22, 2022. 2223-7747 10.3390/plants11223115 2-s2.0-85142663209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plants |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128223421136896 |