Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3748/wjg.v22.i25.5761 http://hdl.handle.net/11449/159007 |
Resumo: | AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant (estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats (n = 23) were randomly divided into (1) non-pregnant, (contractility, n = 6; transit, n = 6); and (2) pregnant (contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry (ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions (3.90 +/- 0.42 cpm and 3.60 +/- 0.36 cpm vs 4.33 +/- 0.25 cpm) and gastric emptying (168 +/- 17 min and 165 +/- 15 min vs 113 +/- 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control (54.23 +/- 15.14 ng/mL and 129.96 +/- 30.52 ng/mL vs 13.25 +/- 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0 (44.3 +/- 15.18 pg/mL vs 24.96 +/- 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. |
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Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant ratsReproductive physiological processSex hormonesGastrointestinal motilityMagnetic fieldsGastric emptyingAIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant (estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats (n = 23) were randomly divided into (1) non-pregnant, (contractility, n = 6; transit, n = 6); and (2) pregnant (contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry (ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions (3.90 +/- 0.42 cpm and 3.60 +/- 0.36 cpm vs 4.33 +/- 0.25 cpm) and gastric emptying (168 +/- 17 min and 165 +/- 15 min vs 113 +/- 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control (54.23 +/- 15.14 ng/mL and 129.96 +/- 30.52 ng/mL vs 13.25 +/- 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0 (44.3 +/- 15.18 pg/mL vs 24.96 +/- 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sao Paulo State Univ, BR-18618970 Botucatu, SP, BrazilUniv Fed Mato Grosso, Inst Ciencias Biol & Saude, Ave Valdon Varjao 6390, BR-78600000 Barra Do Garcas, MT, BrazilUniv Estadual Ciencias Saude Alagoas, BR-57010300 Maceio, AL, BrazilUniv Sao Paulo, BR-14049900 Ribeirao Preto, SP, BrazilSao Paulo State Univ, BR-18618970 Botucatu, SP, BrazilFAPESP: 2010/14845-4FAPESP: 2015/14923-9CNPq: 150456/2009-3Baishideng Publishing Group IncUniversidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso do Sul (UFMS)Univ Estadual Ciencias Saude AlagoasUniversidade de São Paulo (USP)Matos, Juliana Fernandes [UNESP]Americo, Madileine FrancelySinzato, Yuri Karen [UNESP]Volpato, Gustavo TadeuCora, Luciana AparecidaFreitas Calabresi, Marcos Felipe [UNESP]Oliveira, Ricardo BrandtDamasceno, Debora Cristina [UNESP]Arruda Miranda, Jose Ricardo [UNESP]2018-11-26T15:30:45Z2018-11-26T15:30:45Z2016-07-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5761-5768application/pdfhttp://dx.doi.org/10.3748/wjg.v22.i25.5761World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 22, n. 25, p. 5761-5768, 2016.1007-9327http://hdl.handle.net/11449/15900710.3748/wjg.v22.i25.5761WOS:000380763900012WOS000380763900012.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengWorld Journal Of Gastroenterology1,409info:eu-repo/semantics/openAccess2023-10-13T06:03:25Zoai:repositorio.unesp.br:11449/159007Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:44:14.026773Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
title |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
spellingShingle |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats Matos, Juliana Fernandes [UNESP] Reproductive physiological process Sex hormones Gastrointestinal motility Magnetic fields Gastric emptying |
title_short |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
title_full |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
title_fullStr |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
title_full_unstemmed |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
title_sort |
Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats |
author |
Matos, Juliana Fernandes [UNESP] |
author_facet |
Matos, Juliana Fernandes [UNESP] Americo, Madileine Francely Sinzato, Yuri Karen [UNESP] Volpato, Gustavo Tadeu Cora, Luciana Aparecida Freitas Calabresi, Marcos Felipe [UNESP] Oliveira, Ricardo Brandt Damasceno, Debora Cristina [UNESP] Arruda Miranda, Jose Ricardo [UNESP] |
author_role |
author |
author2 |
Americo, Madileine Francely Sinzato, Yuri Karen [UNESP] Volpato, Gustavo Tadeu Cora, Luciana Aparecida Freitas Calabresi, Marcos Felipe [UNESP] Oliveira, Ricardo Brandt Damasceno, Debora Cristina [UNESP] Arruda Miranda, Jose Ricardo [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Mato Grosso do Sul (UFMS) Univ Estadual Ciencias Saude Alagoas Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Matos, Juliana Fernandes [UNESP] Americo, Madileine Francely Sinzato, Yuri Karen [UNESP] Volpato, Gustavo Tadeu Cora, Luciana Aparecida Freitas Calabresi, Marcos Felipe [UNESP] Oliveira, Ricardo Brandt Damasceno, Debora Cristina [UNESP] Arruda Miranda, Jose Ricardo [UNESP] |
dc.subject.por.fl_str_mv |
Reproductive physiological process Sex hormones Gastrointestinal motility Magnetic fields Gastric emptying |
topic |
Reproductive physiological process Sex hormones Gastrointestinal motility Magnetic fields Gastric emptying |
description |
AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant (estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats (n = 23) were randomly divided into (1) non-pregnant, (contractility, n = 6; transit, n = 6); and (2) pregnant (contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry (ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions (3.90 +/- 0.42 cpm and 3.60 +/- 0.36 cpm vs 4.33 +/- 0.25 cpm) and gastric emptying (168 +/- 17 min and 165 +/- 15 min vs 113 +/- 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control (54.23 +/- 15.14 ng/mL and 129.96 +/- 30.52 ng/mL vs 13.25 +/- 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0 (44.3 +/- 15.18 pg/mL vs 24.96 +/- 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-07 2018-11-26T15:30:45Z 2018-11-26T15:30:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3748/wjg.v22.i25.5761 World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 22, n. 25, p. 5761-5768, 2016. 1007-9327 http://hdl.handle.net/11449/159007 10.3748/wjg.v22.i25.5761 WOS:000380763900012 WOS000380763900012.pdf |
url |
http://dx.doi.org/10.3748/wjg.v22.i25.5761 http://hdl.handle.net/11449/159007 |
identifier_str_mv |
World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 22, n. 25, p. 5761-5768, 2016. 1007-9327 10.3748/wjg.v22.i25.5761 WOS:000380763900012 WOS000380763900012.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
World Journal Of Gastroenterology 1,409 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5761-5768 application/pdf |
dc.publisher.none.fl_str_mv |
Baishideng Publishing Group Inc |
publisher.none.fl_str_mv |
Baishideng Publishing Group Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128410514358272 |