Óleo ozonizado via tópica na doença articular degenerativa

• Autor(a) principal: Anzolin, Ana Paula
• Data de Publicação: 2019
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca de teses e dissertações da Universidade de Passo Fundo (BDTD UPF)
• Texto Completo: http://tede.upf.br:8080/jspui/handle/tede/1785
• topic: Ozônio - Tratamento; Osteoartrite; Idosos; Medicina alternativa; SAUDE COLETIVA::SAUDE PUBLICA

Introduction: Aging is a global reality and the legislation should guarantee the right of the population to reach a healthy aging. Among the most common pathologies of the musculoskeletal system in the elderly population, osteoarthrosis is the second most prevalent chronic disease. The treatment aims to improve the quality of life because, so far, there is no known cure. Ozonized oil has proven action in healing wounds, gingivitis, ulcers and appears to be a therapeutic option for the treatment of osteoarthritis. In osteoarthrosis, there is no scientific proof of the benefits of topical ozonated oil. Therefore, the aim of this dissertation was to evaluate whether topical ozone oil in the treatment of osteoarthritis in different limbs reduces pain and inflammatory markers compared to placebo group in patients recruited and diagnosed with osteoarthritis disease. Methods: A randomized, placebo controlled, triple-blind clinical trial was performed and included patients with osteoarthrosis aged over 50 years old, that used ozonated oil or placebo (nonozonated oil) for 60 days. Patients were divided into two homogeneous groups. During the 60 days, the patients underwent several evaluations, such as laboratory analysis, analogue visual scale (VAS) pain assessment and WOMAC scale. Results: 80 patients with osteoarthrosis were evaluated. Pain reduction occurred in both groups, and thus, this pain reduction effect may be related to local daily massage with oil (ozonized or not), and mainly to the placebo effect. No biochemical differences and no decrease in other inflammatory markers were observed, such as C-reactive protein (CRP) or or erythrocyte sedimentation rate (ESR), but these markers are nonspecific in this disease. Conclusion: Ozone delivered in mineral oil for the topical treatment of osteoarthrosis showed a similar effect to the placebo group, both groups reduced pain. Thus refuting the hypothesis of the study, where it was believed that topically ozone oil would reduce pain in this disease. It is suggested that ozone via topical when used on the whole skin, did not reach a good power of penetration. This work was the first placebo-controlled triple-blind clinical trial that confirmed the placebo effect of topical ozonized oil on osteoarthritis