O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática

Detalhes bibliográficos
Autor(a) principal: Fortes, Bibiana Callegaro
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca de teses e dissertações da Universidade de Passo Fundo (BDTD UPF)
Texto Completo: http://tede.upf.br/jspui/handle/tede/1580
Resumo: Tinnitus is a prevalent symptom in the general population, particularly in the elderly, and its treatment is still a challenge in daily clinical practice. Clonazepam is a medication used routinely as a treatment. However, few studies have reported the actual efficacy of this drug for tinnitus relief. Objective: To verify the effect of the use of clonazepam in the treatment of tinnitus in individuals in the process of aging. Method: A systematic review was performed with a meta-analysis according to PRISMA standards and registered in PROSPERO under the number CRD42018087346. The surveys were carried out in the Medline (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), SciELO and Lilacs (Bireme) databases ofarticles published until February 2018, with no language restriction. The inclusion criteria were randomized controlled trials (RCTs) in adults older than 18 years with tinnitus, in which the intervention would be the use of clonazepam in the presence of a control group (medication or placebo) using some evaluation instrumentation for the evaluation of tinnitus. The research was performed independently by two researchers. Results: Among the 133 identified papers, only two met the inclusion criteria and, therefore, were analyzed. The result of the visual analogue scale was the only coincident instrument of the analyzed studies, and was used to compared by means of meta-analysis. A total of n = 96 participants was recorded. The mean of the visual analogue scale was 2.41 with 95% CI (3.62, 1.20). The test for the overall effect obtained was significant (p <0.0001). The heterogeneity was I2= 49%. Through the meta-analysis it was found that clonazepam had a positive effect with statistically significant results in the treatment of tinnitus. However, some counterpoints of the studies are emphasized, such as a small sample, not very homogeneous, short intervention time and uncertain parameters regarding bias risk assessment, which places less credibility on the quality of the results. Conclusion: This systematic review with meta-analysis suggests that clonazepam is an option in the treatment of tinnitus. However, the methodological quality of the articles included, the small sample size and the short intervention period suggest that new RCTs on this subject are needed.
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spelling Wibelinger, Lia Mara51845229053http://lattes.cnpq.br/531649891358162503907355903http://lattes.cnpq.br/2618809518021050Fortes, Bibiana Callegaro2018-12-18T17:15:59Z2018-08-17FORTES, Bibiana Callegaro. O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática. 2018. 53 f. Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2018.http://tede.upf.br/jspui/handle/tede/1580Tinnitus is a prevalent symptom in the general population, particularly in the elderly, and its treatment is still a challenge in daily clinical practice. Clonazepam is a medication used routinely as a treatment. However, few studies have reported the actual efficacy of this drug for tinnitus relief. Objective: To verify the effect of the use of clonazepam in the treatment of tinnitus in individuals in the process of aging. Method: A systematic review was performed with a meta-analysis according to PRISMA standards and registered in PROSPERO under the number CRD42018087346. The surveys were carried out in the Medline (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), SciELO and Lilacs (Bireme) databases ofarticles published until February 2018, with no language restriction. The inclusion criteria were randomized controlled trials (RCTs) in adults older than 18 years with tinnitus, in which the intervention would be the use of clonazepam in the presence of a control group (medication or placebo) using some evaluation instrumentation for the evaluation of tinnitus. The research was performed independently by two researchers. Results: Among the 133 identified papers, only two met the inclusion criteria and, therefore, were analyzed. The result of the visual analogue scale was the only coincident instrument of the analyzed studies, and was used to compared by means of meta-analysis. A total of n = 96 participants was recorded. The mean of the visual analogue scale was 2.41 with 95% CI (3.62, 1.20). The test for the overall effect obtained was significant (p <0.0001). The heterogeneity was I2= 49%. Through the meta-analysis it was found that clonazepam had a positive effect with statistically significant results in the treatment of tinnitus. However, some counterpoints of the studies are emphasized, such as a small sample, not very homogeneous, short intervention time and uncertain parameters regarding bias risk assessment, which places less credibility on the quality of the results. Conclusion: This systematic review with meta-analysis suggests that clonazepam is an option in the treatment of tinnitus. However, the methodological quality of the articles included, the small sample size and the short intervention period suggest that new RCTs on this subject are needed.zumbido é um sintoma bastante prevalente na população em geral, principalmente nos idosos, e o seu tratamento é ainda considerado um desafio na prática clínica diária. Dentre as terapias medicamentosas, tem-se o clonazepam, que é uma medicação utilizada rotineiramente como tratamento. Contudo, poucos são os estudos que afirmam a real eficácia desse medicamento para o alívio do zumbido. Objetivo: Verificar o efeito do uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento. Método: Foi realizada uma revisão sistemática com metanálise de acordo com os padrões do PRISMA e registrada no PROSPERO sob o número CRD42018087346. As pesquisas foram realizadas nas bases de dados Medline (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), SciELO e Lilacs (Bireme) de artigos publicados até fevereiro de 2018, sem restrição de idiomas. Os critérios de inclusão considerados foram ensaios clínicos randomizados (ECR) em adultos com idade superior a 18 anos , portadores do sintoma zumbido em que a intervenção seria o uso declonazepam com presença de grupo controle (medicamento ou placebo) usando algum instrumentação de avaliação para o zumbido. A pesquisa foi feita de forma independente por dois pesquisadores. Resultados: Dentre os 133 artigos identificados apenas dois preencheram os critérios de inclusão e, portanto, analisados. O resultado da escala visual analógica (EVA) foi o único instrumento coincidente dos estudos analisados, sendo esse o instrumento comparado por meio de metanálise. Totalizou-se um n= 96 participantes. A média da EVA foi de 2,41 com IC 95% (3.62, 1.20). O teste para o efeito geral obteve p < 0.0001, sendo tal diferença significativa. A heterogeneidade foi de I2= 49%. Através da metanálise verificou-se que o clonazepam apresentou um efeito positivo com resultados estatisticamente significativos no tratamento do zumbido. No entanto, ressalta-se alguns contrapontos dos estudos, como uma amostra pequena, não muito homogênea, tempo curto de intervenção e parâmetros incertos quanto à avaliação do risco de viés o que deposita menor credibilidade na qualidade dos estudos. Conclusão: Esta revisão sistemática com metanálise sugere que o clonazepam é uma opção de medicamento no tratamento do zumbido. No entanto, a qualidade metodológica dos artigos incluídos, o pequeno tamanho de amostra e o período curto de intervenção sugerem que são necessários novos ECR sobre esse assunto.Submitted by Mariana Freitas (marianafreitas@upf.br) on 2018-12-18T17:15:59Z No. of bitstreams: 1 2018BibianaCallegaroFortes.pdf: 415358 bytes, checksum: 224161c884349e9fc53ba6f103d50ea1 (MD5)Made available in DSpace on 2018-12-18T17:15:59Z (GMT). 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dc.title.por.fl_str_mv O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
dc.title.alternative.eng.fl_str_mv The use of clonazepam in the treatment of tinnitus in aging individuals: a systematic review
title O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
spellingShingle O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
Fortes, Bibiana Callegaro
Tratamento intensivo
Ouvidos
Doenças
Avaliação
SAUDE COLETIVA::SAUDE PUBLICA
title_short O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
title_full O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
title_fullStr O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
title_full_unstemmed O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
title_sort O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática
author Fortes, Bibiana Callegaro
author_facet Fortes, Bibiana Callegaro
author_role author
dc.contributor.advisor1.fl_str_mv Wibelinger, Lia Mara
dc.contributor.advisor1ID.fl_str_mv 51845229053
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/5316498913581625
dc.contributor.authorID.fl_str_mv 03907355903
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2618809518021050
dc.contributor.author.fl_str_mv Fortes, Bibiana Callegaro
contributor_str_mv Wibelinger, Lia Mara
dc.subject.por.fl_str_mv Tratamento intensivo
Ouvidos
Doenças
Avaliação
topic Tratamento intensivo
Ouvidos
Doenças
Avaliação
SAUDE COLETIVA::SAUDE PUBLICA
dc.subject.cnpq.fl_str_mv SAUDE COLETIVA::SAUDE PUBLICA
description Tinnitus is a prevalent symptom in the general population, particularly in the elderly, and its treatment is still a challenge in daily clinical practice. Clonazepam is a medication used routinely as a treatment. However, few studies have reported the actual efficacy of this drug for tinnitus relief. Objective: To verify the effect of the use of clonazepam in the treatment of tinnitus in individuals in the process of aging. Method: A systematic review was performed with a meta-analysis according to PRISMA standards and registered in PROSPERO under the number CRD42018087346. The surveys were carried out in the Medline (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), SciELO and Lilacs (Bireme) databases ofarticles published until February 2018, with no language restriction. The inclusion criteria were randomized controlled trials (RCTs) in adults older than 18 years with tinnitus, in which the intervention would be the use of clonazepam in the presence of a control group (medication or placebo) using some evaluation instrumentation for the evaluation of tinnitus. The research was performed independently by two researchers. Results: Among the 133 identified papers, only two met the inclusion criteria and, therefore, were analyzed. The result of the visual analogue scale was the only coincident instrument of the analyzed studies, and was used to compared by means of meta-analysis. A total of n = 96 participants was recorded. The mean of the visual analogue scale was 2.41 with 95% CI (3.62, 1.20). The test for the overall effect obtained was significant (p <0.0001). The heterogeneity was I2= 49%. Through the meta-analysis it was found that clonazepam had a positive effect with statistically significant results in the treatment of tinnitus. However, some counterpoints of the studies are emphasized, such as a small sample, not very homogeneous, short intervention time and uncertain parameters regarding bias risk assessment, which places less credibility on the quality of the results. Conclusion: This systematic review with meta-analysis suggests that clonazepam is an option in the treatment of tinnitus. However, the methodological quality of the articles included, the small sample size and the short intervention period suggest that new RCTs on this subject are needed.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-18T17:15:59Z
dc.date.issued.fl_str_mv 2018-08-17
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dc.identifier.citation.fl_str_mv FORTES, Bibiana Callegaro. O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática. 2018. 53 f. Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2018.
dc.identifier.uri.fl_str_mv http://tede.upf.br/jspui/handle/tede/1580
identifier_str_mv FORTES, Bibiana Callegaro. O uso do clonazepam no tratamento do zumbido em indivíduos em processo de envelhecimento: uma revisão sistemática. 2018. 53 f. Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2018.
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