Comparação dos níveis séricos de leucina em pacientes com e sem apendicite

Detalhes bibliográficos
Autor(a) principal: Lontra, Marcelo Bentancor
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRGS
Texto Completo: http://hdl.handle.net/10183/218941
Resumo: Background: Acute appendicitis (AA) is the first cause of emergency surgery. Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) has been shown to be a potential biomarker in cases of AA in children, but there are conflicting results for its use in adults. The objective of this study is to compare the mean plasma values of LRG1 in patients with acute abdomen with and without appendicitis Methods: This case-control study was conducted prospectively at the emergency room (ER) of Hospital de Clínicas de Porto Alegre, between March 1st, 2011 and December 31st, 2012. Patients with recente abdominal pain, aged 14-70 years who attended the ER were included in the study. Blood samples were drawn at the initial consultation. Those who were submitted to surgery and had a pathology report of AA were considered as cases. Those without a need of surgery and treated for other conditions, e.g., pelvic inflammatory disease, were considered as controls. Follow-up in controls was made up to 30 days. LRG1 plasma mean values were measured using ELISA kit and compared between groups. Results: A total of 28 participants, 14 cases with acute appendicitis and 14 controls, were included. The median (range) values of leucine-rich alpha-2-glycoprotein-1 level in the group with appendicitis and control group were 8.8 ng/ml (5.5 to 31) and 11 (4.6 to 108) ng/ml, respectively (Mann-Whitney test P=0.26). Conclusion: serum leucine-rich alpha-2-glycoprotein-1 levels were not useful in diagnosing Acute Appendicitis in patients with acute abdominal pain.
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spelling Lontra, Marcelo BentancorCavazzola, Leandro TottiSavaris, Ricardo Francalacci2021-03-17T04:18:27Z2020http://hdl.handle.net/10183/218941001122913Background: Acute appendicitis (AA) is the first cause of emergency surgery. Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) has been shown to be a potential biomarker in cases of AA in children, but there are conflicting results for its use in adults. The objective of this study is to compare the mean plasma values of LRG1 in patients with acute abdomen with and without appendicitis Methods: This case-control study was conducted prospectively at the emergency room (ER) of Hospital de Clínicas de Porto Alegre, between March 1st, 2011 and December 31st, 2012. Patients with recente abdominal pain, aged 14-70 years who attended the ER were included in the study. Blood samples were drawn at the initial consultation. Those who were submitted to surgery and had a pathology report of AA were considered as cases. Those without a need of surgery and treated for other conditions, e.g., pelvic inflammatory disease, were considered as controls. Follow-up in controls was made up to 30 days. LRG1 plasma mean values were measured using ELISA kit and compared between groups. Results: A total of 28 participants, 14 cases with acute appendicitis and 14 controls, were included. The median (range) values of leucine-rich alpha-2-glycoprotein-1 level in the group with appendicitis and control group were 8.8 ng/ml (5.5 to 31) and 11 (4.6 to 108) ng/ml, respectively (Mann-Whitney test P=0.26). Conclusion: serum leucine-rich alpha-2-glycoprotein-1 levels were not useful in diagnosing Acute Appendicitis in patients with acute abdominal pain.application/pdfporBiomarcadoresApendiciteLeucinaGlicoproteinasAcute appendicitisLeucine-rich alpha-2-glycoprotein-1BiomarkersComparação dos níveis séricos de leucina em pacientes com e sem apendiciteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisUniversidade Federal do Rio Grande do SulFaculdade de MedicinaPrograma de Pós-Graduação em Medicina: Ciências CirúrgicasPorto Alegre, BR-RS2020mestradoinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001122913.pdf.txt001122913.pdf.txtExtracted Texttext/plain80180http://www.lume.ufrgs.br/bitstream/10183/218941/2/001122913.pdf.txtfeecbc83020449c80430d9e1f0f850aeMD52ORIGINAL001122913.pdfTexto completoapplication/pdf808867http://www.lume.ufrgs.br/bitstream/10183/218941/1/001122913.pdfc30520b1c877fcd2749a7be211f20eefMD5110183/2189412021-05-07 04:56:09.135117oai:www.lume.ufrgs.br:10183/218941Biblioteca Digital de Teses e Dissertaçõeshttps://lume.ufrgs.br/handle/10183/2PUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.br||lume@ufrgs.bropendoar:18532021-05-07T07:56:09Biblioteca Digital de Teses e Dissertações da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
title Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
spellingShingle Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
Lontra, Marcelo Bentancor
Biomarcadores
Apendicite
Leucina
Glicoproteinas
Acute appendicitis
Leucine-rich alpha-2-glycoprotein-1
Biomarkers
title_short Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
title_full Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
title_fullStr Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
title_full_unstemmed Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
title_sort Comparação dos níveis séricos de leucina em pacientes com e sem apendicite
author Lontra, Marcelo Bentancor
author_facet Lontra, Marcelo Bentancor
author_role author
dc.contributor.author.fl_str_mv Lontra, Marcelo Bentancor
dc.contributor.advisor1.fl_str_mv Cavazzola, Leandro Totti
dc.contributor.advisor-co1.fl_str_mv Savaris, Ricardo Francalacci
contributor_str_mv Cavazzola, Leandro Totti
Savaris, Ricardo Francalacci
dc.subject.por.fl_str_mv Biomarcadores
Apendicite
Leucina
Glicoproteinas
topic Biomarcadores
Apendicite
Leucina
Glicoproteinas
Acute appendicitis
Leucine-rich alpha-2-glycoprotein-1
Biomarkers
dc.subject.eng.fl_str_mv Acute appendicitis
Leucine-rich alpha-2-glycoprotein-1
Biomarkers
description Background: Acute appendicitis (AA) is the first cause of emergency surgery. Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) has been shown to be a potential biomarker in cases of AA in children, but there are conflicting results for its use in adults. The objective of this study is to compare the mean plasma values of LRG1 in patients with acute abdomen with and without appendicitis Methods: This case-control study was conducted prospectively at the emergency room (ER) of Hospital de Clínicas de Porto Alegre, between March 1st, 2011 and December 31st, 2012. Patients with recente abdominal pain, aged 14-70 years who attended the ER were included in the study. Blood samples were drawn at the initial consultation. Those who were submitted to surgery and had a pathology report of AA were considered as cases. Those without a need of surgery and treated for other conditions, e.g., pelvic inflammatory disease, were considered as controls. Follow-up in controls was made up to 30 days. LRG1 plasma mean values were measured using ELISA kit and compared between groups. Results: A total of 28 participants, 14 cases with acute appendicitis and 14 controls, were included. The median (range) values of leucine-rich alpha-2-glycoprotein-1 level in the group with appendicitis and control group were 8.8 ng/ml (5.5 to 31) and 11 (4.6 to 108) ng/ml, respectively (Mann-Whitney test P=0.26). Conclusion: serum leucine-rich alpha-2-glycoprotein-1 levels were not useful in diagnosing Acute Appendicitis in patients with acute abdominal pain.
publishDate 2020
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