Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/37451 |
Resumo: | Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer’s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mild to moderate AD patients in order to identify a possible role for this neurotrophin in preclinical and early stages of AD. Methods: BDNF serum levels were measured by sandwich-ELISA in healthy elderly (n=20), amnestic MCI patients (n=15) and AD patients (n=25), 12 mild and 13 moderate. MMSE scores, level of education and age were analyzed for a possible correlation with BDNF levels. Results: BDNF serum levels were significantly different between MCI patients and healthy subjects (p=0.003); MCI and mild AD patients (p=0.023); and MCI and moderate AD patients (p=0.050). BDNF showed no correlation with MMSE scores, age or level of education. Limitations: The small sample size in the present investigation could be a limitation. However, we carried out a power calculation that showed values higher than 80% for a confidence level of 95%. Conclusion: The fact that BDNF serum levels differentiated amnestic MCI patients from healthy elderly and AD patients suggests a possible role for BDNF as a preclinical biomarker of AD. |
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Borba, Ericksen MielleChaves, Marcia Lorena Fagundes2012-03-13T01:19:55Z2012http://hdl.handle.net/10183/37451000821798Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer’s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mild to moderate AD patients in order to identify a possible role for this neurotrophin in preclinical and early stages of AD. Methods: BDNF serum levels were measured by sandwich-ELISA in healthy elderly (n=20), amnestic MCI patients (n=15) and AD patients (n=25), 12 mild and 13 moderate. MMSE scores, level of education and age were analyzed for a possible correlation with BDNF levels. Results: BDNF serum levels were significantly different between MCI patients and healthy subjects (p=0.003); MCI and mild AD patients (p=0.023); and MCI and moderate AD patients (p=0.050). BDNF showed no correlation with MMSE scores, age or level of education. Limitations: The small sample size in the present investigation could be a limitation. However, we carried out a power calculation that showed values higher than 80% for a confidence level of 95%. Conclusion: The fact that BDNF serum levels differentiated amnestic MCI patients from healthy elderly and AD patients suggests a possible role for BDNF as a preclinical biomarker of AD.application/pdfporDisfunção cognitivaDoença de AlzheimerFatores de crescimento neuralFator neurotrófico derivado do encéfaloAssociação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisUniversidade Federal do Rio Grande do SulFaculdade de MedicinaPrograma de Pós-Graduação em Medicina: Ciências MédicasPorto Alegre, BR-RS2012mestradoinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000821798.pdf.txt000821798.pdf.txtExtracted Texttext/plain81536http://www.lume.ufrgs.br/bitstream/10183/37451/2/000821798.pdf.txt5767fad755eccd28a2a22acc05265994MD52ORIGINAL000821798.pdf000821798.pdfTexto completoapplication/pdf541979http://www.lume.ufrgs.br/bitstream/10183/37451/1/000821798.pdf37036699fea7a0f85fa84add5c58b19dMD51THUMBNAIL000821798.pdf.jpg000821798.pdf.jpgGenerated Thumbnailimage/jpeg1195http://www.lume.ufrgs.br/bitstream/10183/37451/3/000821798.pdf.jpg17dc69d7f3cc2a2f1e884868b23f6d19MD5310183/374512024-01-10 04:35:51.302214oai:www.lume.ufrgs.br:10183/37451Biblioteca Digital de Teses e Dissertaçõeshttps://lume.ufrgs.br/handle/10183/2PUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.br||lume@ufrgs.bropendoar:18532024-01-10T06:35:51Biblioteca Digital de Teses e Dissertações da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
title |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
spellingShingle |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer Borba, Ericksen Mielle Disfunção cognitiva Doença de Alzheimer Fatores de crescimento neural Fator neurotrófico derivado do encéfalo |
title_short |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
title_full |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
title_fullStr |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
title_full_unstemmed |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
title_sort |
Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer |
author |
Borba, Ericksen Mielle |
author_facet |
Borba, Ericksen Mielle |
author_role |
author |
dc.contributor.author.fl_str_mv |
Borba, Ericksen Mielle |
dc.contributor.advisor1.fl_str_mv |
Chaves, Marcia Lorena Fagundes |
contributor_str_mv |
Chaves, Marcia Lorena Fagundes |
dc.subject.por.fl_str_mv |
Disfunção cognitiva Doença de Alzheimer Fatores de crescimento neural Fator neurotrófico derivado do encéfalo |
topic |
Disfunção cognitiva Doença de Alzheimer Fatores de crescimento neural Fator neurotrófico derivado do encéfalo |
description |
Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer’s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mild to moderate AD patients in order to identify a possible role for this neurotrophin in preclinical and early stages of AD. Methods: BDNF serum levels were measured by sandwich-ELISA in healthy elderly (n=20), amnestic MCI patients (n=15) and AD patients (n=25), 12 mild and 13 moderate. MMSE scores, level of education and age were analyzed for a possible correlation with BDNF levels. Results: BDNF serum levels were significantly different between MCI patients and healthy subjects (p=0.003); MCI and mild AD patients (p=0.023); and MCI and moderate AD patients (p=0.050). BDNF showed no correlation with MMSE scores, age or level of education. Limitations: The small sample size in the present investigation could be a limitation. However, we carried out a power calculation that showed values higher than 80% for a confidence level of 95%. Conclusion: The fact that BDNF serum levels differentiated amnestic MCI patients from healthy elderly and AD patients suggests a possible role for BDNF as a preclinical biomarker of AD. |
publishDate |
2012 |
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