Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRPE |
Texto Completo: | http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5591 |
Resumo: | The directly heat applied on the testis has given new information about the mechanisms triggers of spermatogenesis damages. Pentoxifylline (PTX) is a methylxanthine with antioxidants, anti-inflammatory and anti-apoptotic properties and beside this with a lot of utilities in clinical area. The present work had an objective to evaluate the inhibitory capacity of pentoxifylline on deleterious actions, produced by heat in the testicular parenchyma and its capacity to accelerate the spermatogenesis recovery process. Seventy two male Wistar rats (Rattus norvegicus, var. albinus) were used and divided in control group, heat shock (HS), HS treated with 50mg/Kg of PTX and HS treated with 100mg/Kg of PTX. All animal were submitted to testicular heat shock, excepted the control group and evaluated on 1, 3, 7, 15, 30 and 60 days according to histopathological and histometrical alterations as well as serum levels of testosterone. In this experiment, the different protocols did not produced alteration in the epididymis, prostate and seminal gland weight. However, it was observed a reduction tendency of testicular weight, seminiferous tubule volume, tubular diameter and epithelium height in the animals that suffered heat shock. The Leydig cell volume was reduced in animals submitted to stress thermic, but this fact did not influence the testosterone levels. Utilizing Nile's blue to stain apoptotic cells was noted a reduction in this kind of cell's death in group HS+100mg/Kg of PTX in relation with HS group on 30th days. In the same way was observed reduction on apoptotic cells in the HS+50mg/Kg group, when compared with HS on 60th days. The histopathological found on 3rd, 7th and 15th day post-heat shock are compatible with testis degeneration picture. On these periods, in the animals treated with pentoxifylline, the lesions were minor scale and some stages of seminiferous epithelium cycle were well characterized. In the period between 30 e 60 days after heat shock, we can observe that animals not treated with PTX showed seminiferous tubule with desquamated cells in the lumen, germ epithelium loosening and vacuoles of Sertoli cell. Although, it had been observed partial recovery of spermatogenesis. The animals treated with pentoxifylline with 50 or 100mg/Kg during this period, the spermatogenesis had all stages of seminiferous epithelium cycle. Thus, according to results, PTX seems to have exercised inhibitor role on pro-inflammatory and apoptotic mechanisms, triggered by directly heat shock applied on testis, and for accelerating the of spermatogenic process recovery. |
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SILVA JUNIOR, Valdemiro Amaro daEVÊNCIO NETO, JoaquimAMORIM JÚNIOR, Adelmar Afonso deMAIA, Frederico Celso LyraMENDONÇA, Fábio de SouzaSILVA JUNIOR, Valdemiro Amaro dahttp://lattes.cnpq.br/0216033134349010QUEIROZ, Gian Carlo D'Angelo de2016-10-05T14:27:32Z2010-07-30QUEIROZ, Gian Carlo D'Angelo de. Pentoxifilina : efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular. 2010. 118 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco,Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5591The directly heat applied on the testis has given new information about the mechanisms triggers of spermatogenesis damages. Pentoxifylline (PTX) is a methylxanthine with antioxidants, anti-inflammatory and anti-apoptotic properties and beside this with a lot of utilities in clinical area. The present work had an objective to evaluate the inhibitory capacity of pentoxifylline on deleterious actions, produced by heat in the testicular parenchyma and its capacity to accelerate the spermatogenesis recovery process. Seventy two male Wistar rats (Rattus norvegicus, var. albinus) were used and divided in control group, heat shock (HS), HS treated with 50mg/Kg of PTX and HS treated with 100mg/Kg of PTX. All animal were submitted to testicular heat shock, excepted the control group and evaluated on 1, 3, 7, 15, 30 and 60 days according to histopathological and histometrical alterations as well as serum levels of testosterone. In this experiment, the different protocols did not produced alteration in the epididymis, prostate and seminal gland weight. However, it was observed a reduction tendency of testicular weight, seminiferous tubule volume, tubular diameter and epithelium height in the animals that suffered heat shock. The Leydig cell volume was reduced in animals submitted to stress thermic, but this fact did not influence the testosterone levels. Utilizing Nile's blue to stain apoptotic cells was noted a reduction in this kind of cell's death in group HS+100mg/Kg of PTX in relation with HS group on 30th days. In the same way was observed reduction on apoptotic cells in the HS+50mg/Kg group, when compared with HS on 60th days. The histopathological found on 3rd, 7th and 15th day post-heat shock are compatible with testis degeneration picture. On these periods, in the animals treated with pentoxifylline, the lesions were minor scale and some stages of seminiferous epithelium cycle were well characterized. In the period between 30 e 60 days after heat shock, we can observe that animals not treated with PTX showed seminiferous tubule with desquamated cells in the lumen, germ epithelium loosening and vacuoles of Sertoli cell. Although, it had been observed partial recovery of spermatogenesis. The animals treated with pentoxifylline with 50 or 100mg/Kg during this period, the spermatogenesis had all stages of seminiferous epithelium cycle. Thus, according to results, PTX seems to have exercised inhibitor role on pro-inflammatory and apoptotic mechanisms, triggered by directly heat shock applied on testis, and for accelerating the of spermatogenic process recovery.O calor aplicado diretamente sobre o testículo tem fornecido novas informações sobre os mecanismos desencadeadores dos danos à espermatogênese. A pentoxifilina é uma metilxantina com propriedades antioxidante, antiinflamatória e antiapoptótica com diversas utilidades na área clínica. O presente trabalho teve como objetivo avaliar a capacidade inibidora da pentoxifilina sobre as ações deletérias produzidas pelo calor no parênquima testicular e capacidade em acelerar a recuperação do processo espermatogênico. Foram utilizados 72 ratos Wistar machos (Rattus norvegicus, var. albinus) divididos em grupo controle, choque térmico, choque térmico tratado com 50mg/Kg e 100mg/Kg de pentoxifilina, submetidos ao estresse térmico testicular e avaliados nos dias 1, 3, 7, 15, 30 e 60 quanto as alterações histopatológicas e histomorfométricas dos testículos bem como, aos níveis séricos de testosterona. Neste trabalho, os diferentes protocolos experimentais não produziram alterações no peso do epidídimo, da próstata e glândula seminal. Contudo, foi constatada tendência à redução de peso testicular, do volume total de túbulos seminíferos, diâmetro tubular e altura de epitélio seminífero nos animais que sofreram choque térmico. O volume de células de Leydig reduziu nos animais submetidos ao estresse térmico, porém isto não influenciou os níveis de testosterona. Utilizando-se azul do Nilo para marcação de células apoptóticas foi constatada redução deste tipo de morte celular no grupo HS+100mg/Kg de PTX em relação ao grupo HS aos 30 dias e, 60 dias no grupo choque térmico + 50mg/Kg comparado com o grupo choque térmico. Os achados histopatológicos nos tempos 3, 7 e 15 pós-choque térmico são compatíveis com o quadro de degeneração testicular. Neste período os animais tratados com pentoxifilina as lesões ocorreram em menor escala e alguns estágios do ciclo do epitélio seminíferos foram bem caracterizados. No período compreendido entre 30 e 60 dias após o choque térmico, podemos constatar que os animais não tratados com pentoxifilina possuíam túbulos seminíferos com células que perderam sua coesão em seu lume, afrouxamento do epitélio germinativo e vacúolos nas células de Sertoli, apesar de ter sido observada recuperação parcial do processo espermatogênico. Os animais tratados com pentoxifilina na dose de 50 ou 100mg/Kg, neste período, o processo espermatogênico possuía todos os estágios do ciclo do epitélio seminífero. Portanto, de acordo com os resultados a pentoxifilina exerceu papel inibidor dos mecanismos pró-inflamatórios ou pró-apoptóticos desencadeados pelo choque térmico aplicado diretamente nos testículos, além de acelerar o processo de recuperação da espermatogênese.Submitted by (edna.saturno@ufrpe.br) on 2016-10-05T14:27:32Z No. of bitstreams: 1 Gian Carlo DAngelo de Queiroz1.pdf: 5453543 bytes, checksum: 9dcdbbae128642bdc513a5304225e2f4 (MD5)Made available in DSpace on 2016-10-05T14:27:32Z (GMT). No. of bitstreams: 1 Gian Carlo DAngelo de Queiroz1.pdf: 5453543 bytes, checksum: 9dcdbbae128642bdc513a5304225e2f4 (MD5) Previous issue date: 2010-07-30application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em Biociência AnimalUFRPEBrasilDepartamento de Morfologia e Fisiologia AnimalEspermatogênesePentoxifilinaTestículoPentoxifyllineSpermatogenesiCIENCIAS AGRARIAS::MEDICINA VETERINARIAPentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicularinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-1510757014399315592600600600-8922364187987396204453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPELICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/5591/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALGian Carlo DAngelo de Queiroz1.pdfGian Carlo DAngelo de Queiroz1.pdfapplication/pdf5453543http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/5591/2/Gian+Carlo+DAngelo+de+Queiroz1.pdf9dcdbbae128642bdc513a5304225e2f4MD52tede2/55912023-07-13 15:57:14.873oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-05-28T12:33:15.786230Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false |
dc.title.por.fl_str_mv |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
title |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
spellingShingle |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular QUEIROZ, Gian Carlo D'Angelo de Espermatogênese Pentoxifilina Testículo Pentoxifylline Spermatogenesi CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
title_full |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
title_fullStr |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
title_full_unstemmed |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
title_sort |
Pentoxifilina : Efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular |
author |
QUEIROZ, Gian Carlo D'Angelo de |
author_facet |
QUEIROZ, Gian Carlo D'Angelo de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
SILVA JUNIOR, Valdemiro Amaro da |
dc.contributor.advisor-co1.fl_str_mv |
EVÊNCIO NETO, Joaquim |
dc.contributor.referee1.fl_str_mv |
AMORIM JÚNIOR, Adelmar Afonso de |
dc.contributor.referee2.fl_str_mv |
MAIA, Frederico Celso Lyra |
dc.contributor.referee3.fl_str_mv |
MENDONÇA, Fábio de Souza |
dc.contributor.referee4.fl_str_mv |
SILVA JUNIOR, Valdemiro Amaro da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0216033134349010 |
dc.contributor.author.fl_str_mv |
QUEIROZ, Gian Carlo D'Angelo de |
contributor_str_mv |
SILVA JUNIOR, Valdemiro Amaro da EVÊNCIO NETO, Joaquim AMORIM JÚNIOR, Adelmar Afonso de MAIA, Frederico Celso Lyra MENDONÇA, Fábio de Souza SILVA JUNIOR, Valdemiro Amaro da |
dc.subject.por.fl_str_mv |
Espermatogênese Pentoxifilina Testículo |
topic |
Espermatogênese Pentoxifilina Testículo Pentoxifylline Spermatogenesi CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Pentoxifylline Spermatogenesi |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
The directly heat applied on the testis has given new information about the mechanisms triggers of spermatogenesis damages. Pentoxifylline (PTX) is a methylxanthine with antioxidants, anti-inflammatory and anti-apoptotic properties and beside this with a lot of utilities in clinical area. The present work had an objective to evaluate the inhibitory capacity of pentoxifylline on deleterious actions, produced by heat in the testicular parenchyma and its capacity to accelerate the spermatogenesis recovery process. Seventy two male Wistar rats (Rattus norvegicus, var. albinus) were used and divided in control group, heat shock (HS), HS treated with 50mg/Kg of PTX and HS treated with 100mg/Kg of PTX. All animal were submitted to testicular heat shock, excepted the control group and evaluated on 1, 3, 7, 15, 30 and 60 days according to histopathological and histometrical alterations as well as serum levels of testosterone. In this experiment, the different protocols did not produced alteration in the epididymis, prostate and seminal gland weight. However, it was observed a reduction tendency of testicular weight, seminiferous tubule volume, tubular diameter and epithelium height in the animals that suffered heat shock. The Leydig cell volume was reduced in animals submitted to stress thermic, but this fact did not influence the testosterone levels. Utilizing Nile's blue to stain apoptotic cells was noted a reduction in this kind of cell's death in group HS+100mg/Kg of PTX in relation with HS group on 30th days. In the same way was observed reduction on apoptotic cells in the HS+50mg/Kg group, when compared with HS on 60th days. The histopathological found on 3rd, 7th and 15th day post-heat shock are compatible with testis degeneration picture. On these periods, in the animals treated with pentoxifylline, the lesions were minor scale and some stages of seminiferous epithelium cycle were well characterized. In the period between 30 e 60 days after heat shock, we can observe that animals not treated with PTX showed seminiferous tubule with desquamated cells in the lumen, germ epithelium loosening and vacuoles of Sertoli cell. Although, it had been observed partial recovery of spermatogenesis. The animals treated with pentoxifylline with 50 or 100mg/Kg during this period, the spermatogenesis had all stages of seminiferous epithelium cycle. Thus, according to results, PTX seems to have exercised inhibitor role on pro-inflammatory and apoptotic mechanisms, triggered by directly heat shock applied on testis, and for accelerating the of spermatogenic process recovery. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-07-30 |
dc.date.accessioned.fl_str_mv |
2016-10-05T14:27:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QUEIROZ, Gian Carlo D'Angelo de. Pentoxifilina : efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular. 2010. 118 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco,Recife. |
dc.identifier.uri.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5591 |
identifier_str_mv |
QUEIROZ, Gian Carlo D'Angelo de. Pentoxifilina : efeitos preventivos e/ou restauradores da pentoxifilina sobre a espermatogênese de ratos wistar adultos submetidos a choque térmico testicular. 2010. 118 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco,Recife. |
url |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5591 |
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por |
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openAccess |
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Universidade Federal Rural de Pernambuco |
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Programa de Pós-Graduação em Biociência Animal |
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UFRPE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Departamento de Morfologia e Fisiologia Animal |
publisher.none.fl_str_mv |
Universidade Federal Rural de Pernambuco |
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