Caracterização patológica e gênica (gene P53) dos tumores mamários em cadelas

• Autor(a) principal: SOUZA, Daniela Maria Bastos de
• Data de Publicação: 2006
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRPE
• Texto Completo: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5405
• topic: Cadela; Tumor; Histopatologia; Câncer; Neoplasia; Bitch; Breast; Pathology; CIENCIAS AGRARIAS::MEDICINA VETERINARIA

The canine mammary tumors has high incidence and malignancy being provoked by several risk factors including age, hormonal activity, nutrition, virus, pseudopregnancy and exogenous progestagen. In this work the goal was to characterize the canine mammary tumors, evaluate the implication of the adjacent mamma and the risk factors involvement on the occurrence of the tumors. They were used 50 bitches with mamma tumor diagnosis and submitted to mastectomy of the mamma and 11 normal bitches that were submitted for elective ovariosalpingohisterectomy in Hospital Veterinary of UFRPE. They were picked biopsies of the tumors and of the normal mammas for histopathologic analysis according to the routine techniques. The animals went of varied races having age comprehended between 4 and 19 years for the bitches with tumor and between 7 months and 6 years for the normal bitches, and the ages between 9 and 13 years were to what it presented the biggest neoplasic frequency (48%). Of the 50 tumors, 68% were carcinosarcoms, 24% were carcinomas, 2% benign mixed tumor, 2% hemorrhagic, 2% fibrosises and 2% were inflammatory processes. The relation of the tumors with the risk factors did not are demonstrate when compared between the malignant tumors and between the normal bitches and the tumor carriers. Of the adjacent mammas, just 36% were normal, 48% presented carcinoma, 6% carcinosarcoms, 2% hiperplasy, 2% fibrosis and in 6% the material was not enough to guarantee the diagnosis. It concludes that in these animals there was no interference of the factors pseudopregnancy and contraceptives use in the appearance of the tumors, but that the age is an important factor, being the more seniorest susceptible. Considering the tumors high frequency in the adjacent mammas to tumour mammas, it suggests the withdrawal of all the mammary chain of the attacked side