Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRPE |
Texto Completo: | http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6376 |
Resumo: | In this work, a comparative electrochemical study of 15 compounds derived from 1,4-naphthoquinone, including lawsone, using cyclic voltammetry and others techniques, was performed on searching for an understanding of the mechanisms involved in the bioactive processes and on designing new potentially more efficient derivatives against the snail Biomphalaria glabrata, the main intermediary of Schistosoma mansoni, the schistosomiasis’ vector. The studies were carried out in aprotic medium using dimethylsulfoxide (DMSO) as solvent and tetrabutylammonium perchlorate (TBAP) as supporting electrolyte. All compounds showed to be electroactive, with at least two pairs of waves, which underwent electrochemical potential displacement from oneanother in accordance to the chemical characteristics of the substituent group. The voltammogram of one of the studied compounds showed a particular greater complexity,therefore, a more detailed study in others electrodes was carried out for investigating its electrochemical behavior. For all the studied compounds, no direct two-way relationship was observed between the electrochemical properties and biological activity, but, the compounds with higher biological activity also presented higher reduction potentials, in good agreement to the literature. A derivative compound proposed on the basis of the overall tendency observed presented the expected electrochemical properties and showed good molluscicidal activity |
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NASCIMENTO, Valberes Bernardo doGALINDO, Fabiane Caxico de AbreuCÂMARA, Celso de AmorimGOULART, Marília Oliveira FonsecaNAVARRO, MarceloOLIVEIRA, Ronaldo Nascimento dehttp://lattes.cnpq.br/2662509152265186SELVA, Thiago Matheus Guimarães2017-02-15T15:06:57Z2010-07-15SELVA, Thiago Matheus Guimarães. Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Química) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6376In this work, a comparative electrochemical study of 15 compounds derived from 1,4-naphthoquinone, including lawsone, using cyclic voltammetry and others techniques, was performed on searching for an understanding of the mechanisms involved in the bioactive processes and on designing new potentially more efficient derivatives against the snail Biomphalaria glabrata, the main intermediary of Schistosoma mansoni, the schistosomiasis’ vector. The studies were carried out in aprotic medium using dimethylsulfoxide (DMSO) as solvent and tetrabutylammonium perchlorate (TBAP) as supporting electrolyte. All compounds showed to be electroactive, with at least two pairs of waves, which underwent electrochemical potential displacement from oneanother in accordance to the chemical characteristics of the substituent group. The voltammogram of one of the studied compounds showed a particular greater complexity,therefore, a more detailed study in others electrodes was carried out for investigating its electrochemical behavior. For all the studied compounds, no direct two-way relationship was observed between the electrochemical properties and biological activity, but, the compounds with higher biological activity also presented higher reduction potentials, in good agreement to the literature. A derivative compound proposed on the basis of the overall tendency observed presented the expected electrochemical properties and showed good molluscicidal activityNo presente trabalho, um estudo eletroquímico comparativo de 15 compostos derivados da 1,4-naftoquinona, incluindo a lausona, utilizando voltametria cíclica e outras técnicas, foi realizado em busca da compreensão dos mecanismos envolvidos nos processos bioativos e do design de novos derivados potencialmente mais eficientes contra o molusco Biomphalaria glabrata, o principal intermediário do Schistosoma mansoni, o transmissor da esquistossomose. Os estudos foram realizados em meio aprótico utilizando dimetilsulfóxido (DMSO) como solvente e perclorato de tetrabutilamônio (TBAP) como eletrólito suporte. Todos os compostos mostraram-se eletroativos, apresentando pelo menos dois pares de ondas, cujos potenciais de pico foram diretamente dependentes dos grupos substituintes. O voltamograma de um dos compostos apresentou maior e particular complexidade, portanto, um estudo mais detalhado em outros eletrodos foi realizado a fim de tentar elucidar seu comportamento eletroquímico. Para todos os compostos estudados, nenhuma relação biunívoca foi observada entre os dados eletroquímicos e a atividade biológica dos compostos, porém, os compostos com maior atividade biológica apresentaram altos potenciais de redução, corroborando a literatura. Um derivado proposto com base na tendência observada neste estudo comparativo apresentou propriedades eletroquímicas esperadas e mostrou atividade moluscicida promissora.Submitted by (lucia.rodrigues@ufrpe.br) on 2017-02-15T15:06:57Z No. of bitstreams: 1 Thiago Matheus Guimaraes Selva.pdf: 458046 bytes, checksum: ffc57ddcaee0a5a696e57c06b7be999f (MD5)Made available in DSpace on 2017-02-15T15:06:57Z (GMT). No. of bitstreams: 1 Thiago Matheus Guimaraes Selva.pdf: 458046 bytes, checksum: ffc57ddcaee0a5a696e57c06b7be999f (MD5) Previous issue date: 2010-07-15application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em QuímicaUFRPEBrasilDepartamento de QuímicaAtividade moluscicidaNaftoquinonaVoltametria cíclicaCIENCIAS EXATAS E DA TERRA::QUIMICAEstudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicidainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis143564836222510089860060060038064160554570910301571700325303117195info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPELICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/6376/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALThiago Matheus Guimaraes Selva.pdfThiago Matheus Guimaraes Selva.pdfapplication/pdf458046http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/6376/2/Thiago+Matheus+Guimaraes+Selva.pdfffc57ddcaee0a5a696e57c06b7be999fMD52tede2/63762018-06-19 11:50:34.972oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-05-28T12:34:15.887630Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false |
dc.title.por.fl_str_mv |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
title |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
spellingShingle |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida SELVA, Thiago Matheus Guimarães Atividade moluscicida Naftoquinona Voltametria cíclica CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
title_full |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
title_fullStr |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
title_full_unstemmed |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
title_sort |
Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida |
author |
SELVA, Thiago Matheus Guimarães |
author_facet |
SELVA, Thiago Matheus Guimarães |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
NASCIMENTO, Valberes Bernardo do |
dc.contributor.advisor-co1.fl_str_mv |
GALINDO, Fabiane Caxico de Abreu |
dc.contributor.referee1.fl_str_mv |
CÂMARA, Celso de Amorim |
dc.contributor.referee2.fl_str_mv |
GOULART, Marília Oliveira Fonseca |
dc.contributor.referee3.fl_str_mv |
NAVARRO, Marcelo |
dc.contributor.referee4.fl_str_mv |
OLIVEIRA, Ronaldo Nascimento de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2662509152265186 |
dc.contributor.author.fl_str_mv |
SELVA, Thiago Matheus Guimarães |
contributor_str_mv |
NASCIMENTO, Valberes Bernardo do GALINDO, Fabiane Caxico de Abreu CÂMARA, Celso de Amorim GOULART, Marília Oliveira Fonseca NAVARRO, Marcelo OLIVEIRA, Ronaldo Nascimento de |
dc.subject.por.fl_str_mv |
Atividade moluscicida Naftoquinona Voltametria cíclica |
topic |
Atividade moluscicida Naftoquinona Voltametria cíclica CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
In this work, a comparative electrochemical study of 15 compounds derived from 1,4-naphthoquinone, including lawsone, using cyclic voltammetry and others techniques, was performed on searching for an understanding of the mechanisms involved in the bioactive processes and on designing new potentially more efficient derivatives against the snail Biomphalaria glabrata, the main intermediary of Schistosoma mansoni, the schistosomiasis’ vector. The studies were carried out in aprotic medium using dimethylsulfoxide (DMSO) as solvent and tetrabutylammonium perchlorate (TBAP) as supporting electrolyte. All compounds showed to be electroactive, with at least two pairs of waves, which underwent electrochemical potential displacement from oneanother in accordance to the chemical characteristics of the substituent group. The voltammogram of one of the studied compounds showed a particular greater complexity,therefore, a more detailed study in others electrodes was carried out for investigating its electrochemical behavior. For all the studied compounds, no direct two-way relationship was observed between the electrochemical properties and biological activity, but, the compounds with higher biological activity also presented higher reduction potentials, in good agreement to the literature. A derivative compound proposed on the basis of the overall tendency observed presented the expected electrochemical properties and showed good molluscicidal activity |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-07-15 |
dc.date.accessioned.fl_str_mv |
2017-02-15T15:06:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SELVA, Thiago Matheus Guimarães. Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Química) - Universidade Federal Rural de Pernambuco, Recife. |
dc.identifier.uri.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6376 |
identifier_str_mv |
SELVA, Thiago Matheus Guimarães. Estudos eletroquímicos da lausona (2-hidroxi-1,4 naftoquinona) e derivados da 1,4 – naftoquinona com atividade moluscicida. 2010. 67 f. Dissertação (Programa de Pós-Graduação em Química) - Universidade Federal Rural de Pernambuco, Recife. |
url |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6376 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
1435648362225100898 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
3806416055457091030 |
dc.relation.cnpq.fl_str_mv |
1571700325303117195 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal Rural de Pernambuco |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UFRPE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Departamento de Química |
publisher.none.fl_str_mv |
Universidade Federal Rural de Pernambuco |
dc.source.none.fl_str_mv |
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Biblioteca Digital de Teses e Dissertações da UFRPE |
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Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE) |
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