Uso do potencial visual evocado por flashes de luz e eletrorretinograma de campo total em cães idosos

• Autor(a) principal: TEIXEIRA, Cristiane Faierstein
• Data de Publicação: 2020
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRPE
• Texto Completo: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/8722
• topic: Cão; Demência de Alzheimer; Disfunção cognitiva canina; Doença neurológica; Tomografia computadorizada; CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Canine cognitive dysfunction (CCD) is characterized by neurodegenerative changes and usually begins to appear with age. This canine dysfunction shares similarities with human dementia - Alzheimer's disease. The changes related to aging are usually progressive and irreversible. The diagnosis of CCD is made mainly by questionnaires based on clinical assessment scales on behavioral changes; by measuring β-amyloid biomarkers in cerebrospinal fluid (CSF) and computed tomography. The use of VEP-F as an aid to the diagnosis of CCD is still scarce. The most current limiting factor in terms of research in dogs with CCD is the absence of an evidence-based tool for the assessment and accurate monitoring of clinical evolution or response to therapy. Objective: to standardize this test as a promising tool for the diagnosis of cognitive dysfunction in elderly dogs. Material and Methods: For the development of the study 14 dogs were used in total. These animals were divided into 3 groups: CCD Group (6 animals> 8 years old), Control Group 1 (4 animals> 8 years old) and Control Group 2 (4 animals <8 years old). Retinal assessment was performed using the full-field and post-retinal ERG by examining the Evoked Visual Potential by flashes of light. Results: The mean P2 peak latency in the CCD groups, Control Group 1 and Control Group 2 was 31.8ms (p = 4.5), 34.7ms (p = 3.0) and 50.4ms (p = 30.6) respectively. The mean for peak P3 latency in the CCD groups, Control Group 1 and Control Group 2 was 141.5 (p = 58.7), 125.5 (p = 55.3) and 105.9 (p = 25.5) respectively. Conclusion: The use of VEP-F should be considered as a useful tool to assess and monitor the progression of CCD.