Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias

Detalhes bibliográficos
Autor(a) principal: COSTA NETO, Eduardo de Oliveira
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRPE
Texto Completo: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5359
Resumo: Tumor of the breast is the most common tumor in bitches, and how to apprimorate the methods to investigative about its origin and development causes is a new research in order to unravel the mechanisms established by the body in an attempt to defend against this disease. The goal of this study was to investigate the expression of extracellular heat shock protein (HSPs) to the bone marrow and peripheral levels in bitches with mammary tumors, met in the Veterinary Hospital outpatient service of the Universidade Federal Rural de Pernambuco, 40 samples were collected from these bitches, 20 were with mammary tumors, and were forwarded to mastectomy forming the group study, and other clinically healthy 20 bitches were forwarded to sterilization (O.S.H) elective (control group). HSP 90 kDa has been detected in 85% of the samples of peripheral level study group, 60% samples of the bone marrow in the same group and 35% of the samples of peripheral level control group. Another protein detected was the molecular weight 150 kDa, also regarded as linked to cellular stress, her expression was appear in 25% of the samples at bone marrow and in 75% of the samples at peripheral level group study. Generally, the results obtained demonstrate there is expression of sorological proteins linked to cellular stress both at the peripheral and bone marrow levels in bitches with mammary tumors, though we cannot say that their extra-cellular expressions are connected only at presence of tumor.
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spelling COELHO, Maria Cristina de Oliveira CardosoRÊGO, Eneida WilcoxTEIXEIRA, Mírian NogueiraALENCAR, Sylvana Pontual dehttp://lattes.cnpq.br/6761761960085563COSTA NETO, Eduardo de Oliveira2016-08-16T15:29:05Z2011-02-16COSTA NETO, Eduardo de Oliveira. Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias. 2011. 51 f.Dissertação (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5359Tumor of the breast is the most common tumor in bitches, and how to apprimorate the methods to investigative about its origin and development causes is a new research in order to unravel the mechanisms established by the body in an attempt to defend against this disease. The goal of this study was to investigate the expression of extracellular heat shock protein (HSPs) to the bone marrow and peripheral levels in bitches with mammary tumors, met in the Veterinary Hospital outpatient service of the Universidade Federal Rural de Pernambuco, 40 samples were collected from these bitches, 20 were with mammary tumors, and were forwarded to mastectomy forming the group study, and other clinically healthy 20 bitches were forwarded to sterilization (O.S.H) elective (control group). HSP 90 kDa has been detected in 85% of the samples of peripheral level study group, 60% samples of the bone marrow in the same group and 35% of the samples of peripheral level control group. Another protein detected was the molecular weight 150 kDa, also regarded as linked to cellular stress, her expression was appear in 25% of the samples at bone marrow and in 75% of the samples at peripheral level group study. Generally, the results obtained demonstrate there is expression of sorological proteins linked to cellular stress both at the peripheral and bone marrow levels in bitches with mammary tumors, though we cannot say that their extra-cellular expressions are connected only at presence of tumor.O tumor de mama é a neoplasia mais frequente nas cadelas, e o aprimoramento de métodos investigatórios sobre sua origem e desenvolvimento fazem com que novas pesquisas surjam no intuito de desvendar os mecanismos elaborados pelo organismo na tentativa de se defender contra esta enfermidade. A expressão da proteína de choque térmico (HSP) tem sido observada em muitas neoplasias, incluindo o câncer de mama. O objetivo deste trabalho foi investigar a expressão extracelular das proteínas de choque térmico (HSPs) a níveis medular e periférico em cadelas portadoras de neoplasias mamárias atendidas no serviço ambulatorial do Hospital Veterinário da Universidade Federal Rural de Pernambuco. Foram coletadas amostras de 40 cadelas, destas, 20 eram portadoras de neoplasias mamárias e foram encaminhas para mastectomia formando o grupo estudo, e outras 20 cadelas clinicamente sadias foram encaminhadas para cirurgia de ovariosalpingohisterectomia (OSH) eletiva (grupo controle). A HSP 90 kDa foi detectada em 20% das amostras do grupo estudo e em 10 % das amostras do grupo controle a nível periférico e a HSP 99 kDa se expressou em 50% das amostras do grupo estudo a nível medular. Outra proteína detectada foi a de peso molecular 150 kDa, também considerada como proteína ligada ao estresse celular, sua expressão foi evidênciada em 25% das amostras a nível medular no grupo estudo. De um modo geral, os resultados obtidos demonstraram haver expressão sorológica das proteínas ligadas ao estresse celular tanto a nível medular quanto a nível periférico em cadelas portadoras de neoplasias mamárias, porém não se pode afirmar que a suas expressões extracelulares estejam ligadas unicamente à presença da neoplasia.Submitted by (edna.saturno@ufrpe.br) on 2016-08-16T15:29:05Z No. of bitstreams: 1 Eduardo de Oliveira Costa Neto.pdf: 806133 bytes, checksum: 9ada3e1ac83723a3256ede794f48e79f (MD5)Made available in DSpace on 2016-08-16T15:29:05Z (GMT). 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dc.title.por.fl_str_mv Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
title Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
spellingShingle Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
COSTA NETO, Eduardo de Oliveira
Tumor de mama
Cadela
Dog
Bone Marrow
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
title_full Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
title_fullStr Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
title_full_unstemmed Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
title_sort Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias
author COSTA NETO, Eduardo de Oliveira
author_facet COSTA NETO, Eduardo de Oliveira
author_role author
dc.contributor.advisor1.fl_str_mv COELHO, Maria Cristina de Oliveira Cardoso
dc.contributor.advisor-co1.fl_str_mv RÊGO, Eneida Wilcox
dc.contributor.referee1.fl_str_mv TEIXEIRA, Mírian Nogueira
dc.contributor.referee2.fl_str_mv ALENCAR, Sylvana Pontual de
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6761761960085563
dc.contributor.author.fl_str_mv COSTA NETO, Eduardo de Oliveira
contributor_str_mv COELHO, Maria Cristina de Oliveira Cardoso
RÊGO, Eneida Wilcox
TEIXEIRA, Mírian Nogueira
ALENCAR, Sylvana Pontual de
dc.subject.por.fl_str_mv Tumor de mama
Cadela
topic Tumor de mama
Cadela
Dog
Bone Marrow
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv Dog
Bone Marrow
dc.subject.cnpq.fl_str_mv CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description Tumor of the breast is the most common tumor in bitches, and how to apprimorate the methods to investigative about its origin and development causes is a new research in order to unravel the mechanisms established by the body in an attempt to defend against this disease. The goal of this study was to investigate the expression of extracellular heat shock protein (HSPs) to the bone marrow and peripheral levels in bitches with mammary tumors, met in the Veterinary Hospital outpatient service of the Universidade Federal Rural de Pernambuco, 40 samples were collected from these bitches, 20 were with mammary tumors, and were forwarded to mastectomy forming the group study, and other clinically healthy 20 bitches were forwarded to sterilization (O.S.H) elective (control group). HSP 90 kDa has been detected in 85% of the samples of peripheral level study group, 60% samples of the bone marrow in the same group and 35% of the samples of peripheral level control group. Another protein detected was the molecular weight 150 kDa, also regarded as linked to cellular stress, her expression was appear in 25% of the samples at bone marrow and in 75% of the samples at peripheral level group study. Generally, the results obtained demonstrate there is expression of sorological proteins linked to cellular stress both at the peripheral and bone marrow levels in bitches with mammary tumors, though we cannot say that their extra-cellular expressions are connected only at presence of tumor.
publishDate 2011
dc.date.issued.fl_str_mv 2011-02-16
dc.date.accessioned.fl_str_mv 2016-08-16T15:29:05Z
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dc.identifier.citation.fl_str_mv COSTA NETO, Eduardo de Oliveira. Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias. 2011. 51 f.Dissertação (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife.
dc.identifier.uri.fl_str_mv http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5359
identifier_str_mv COSTA NETO, Eduardo de Oliveira. Expressão extracelular das proteínas de choque térmico a níveis medular e periférico em cadelas (Canis familiaris) portadoras de neoplasias mamárias. 2011. 51 f.Dissertação (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife.
url http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5359
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dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Departamento de Medicina Veterinária
publisher.none.fl_str_mv Universidade Federal Rural de Pernambuco
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