Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRPE |
Texto Completo: | http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/9677 |
Resumo: | Due to their large-scale use, insecticides are among the most important risk factors for the health of man, animals, and the environment. As an alternative to the use of chemical insecticides, bioinsecticides based on the Cry proteins of Bacillus thuringiensis are a significant and widely used strategy against insect pests. However, although these proteins are considered safe for vertebrates, studies have shown results that disagree with this statement. Therefore, this research aims to investigate the possible effects on reproductive, hepatic and renal morphophysiology in puppies of rats that received the biological insecticides XenTari® WG and Dipel® during pregnancy and lactation. Twenty rats, Rattus norvegicus albinus of the Wistar strain, 90 days old, mated and divided into the following groups were used: CG - Pregnant rats; GX - Pregnant rats that received XenTari® WG (B. thuringiensis subsp. Aizawai); GDi - Pregnant rats that received Dipel® (B. thuringiensis var. Kurstaki); and GDe - Pregnant rats that received deltamethrin (Keshet® 25EC). Insecticides were administered by gavage, at a dosage of 1mg/100g/day (Groups GX and GDi), and 2mg/Kg/day (Group GDe), throughout pregnancy and lactation. The results revealed that the administration of biological and synthetic insecticides reduced the weight gain of the matrices when compared to the control group. Biological insecticides also promoted a reduction in offspring, weight, and length, causing malformation and mortality. There was a delay in the vaginal opening period, an increase in the metestrus about the other phases, a reduction in estrogen, progesterone (females) and testosterone (males), ovaries with numerous tertiary follicles, atresia and few corpus luteum in the offspring of the three groups that received insecticides and, only in the XenTari® and Dipel® groups, histopathological changes in the testicles were observed, with vacuolations and desquamation of the seminiferous epithelium. Quantitative analysis of androgen and estrogen receptors revealed a significant reduction for both offspring gonads whose rats received biological insecticides and deltamethrin, and in these same groups, testicular morphometry revealed a reduction in tubular diameter, height of seminiferous epithelium and tubular total length, and in the ovaries there was a smaller number of primary, secondary and corpus luteum follicles, and an increase in the number of tertiary and atretic follicles. The administration of insecticides also reduced the levels of biomarkers of toxicity alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine, and the biological insecticides promoted histopathological changes in the liver, with the presence of portal vein, centrilobular and sinusoid capillaries congestion, and in the kidney, presence of cortical congestion and reduction of the subcapsular space. There was a significant reduction in glycogen in the liver, and the morphometry revealed a reduction in the lobular parenchyma and an increase in the non-lobular parenchyma, while in the kidney there was a reduction in the diameter and volume of the glomerulus and Bowman's capsule in the offspring of the rats treated with the insecticides. Thus, it is concluded that both the biological insecticides XenTari® and Dipel®, as well as the synthetic insecticide deltamethrin, in sublethal doses in pregnant rats, promote reproductive, hepatic and renal changes, and in the development of the puppies, being which last until the adult phase, most of these effects were even more expressive in the groups that received biological insecticides. |
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TEIXEIRA, Álvaro Aguiar CoelhoTEIXEIRA, Valéria WanderleyMELO, Ismaela Maria Ferreira deJORDÃO, Ana Janaína Jeanine Martins de LemosSILVA JUNIOR, Valdemiro Amaro dahttp://lattes.cnpq.br/0700922711295090ALVES, Rebeka da Costa2024-07-22T14:10:16Z2020-02-19ALVES, Rebeka da Costa. Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar. 2020. 94 f. Tese (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/9677Due to their large-scale use, insecticides are among the most important risk factors for the health of man, animals, and the environment. As an alternative to the use of chemical insecticides, bioinsecticides based on the Cry proteins of Bacillus thuringiensis are a significant and widely used strategy against insect pests. However, although these proteins are considered safe for vertebrates, studies have shown results that disagree with this statement. Therefore, this research aims to investigate the possible effects on reproductive, hepatic and renal morphophysiology in puppies of rats that received the biological insecticides XenTari® WG and Dipel® during pregnancy and lactation. Twenty rats, Rattus norvegicus albinus of the Wistar strain, 90 days old, mated and divided into the following groups were used: CG - Pregnant rats; GX - Pregnant rats that received XenTari® WG (B. thuringiensis subsp. Aizawai); GDi - Pregnant rats that received Dipel® (B. thuringiensis var. Kurstaki); and GDe - Pregnant rats that received deltamethrin (Keshet® 25EC). Insecticides were administered by gavage, at a dosage of 1mg/100g/day (Groups GX and GDi), and 2mg/Kg/day (Group GDe), throughout pregnancy and lactation. The results revealed that the administration of biological and synthetic insecticides reduced the weight gain of the matrices when compared to the control group. Biological insecticides also promoted a reduction in offspring, weight, and length, causing malformation and mortality. There was a delay in the vaginal opening period, an increase in the metestrus about the other phases, a reduction in estrogen, progesterone (females) and testosterone (males), ovaries with numerous tertiary follicles, atresia and few corpus luteum in the offspring of the three groups that received insecticides and, only in the XenTari® and Dipel® groups, histopathological changes in the testicles were observed, with vacuolations and desquamation of the seminiferous epithelium. Quantitative analysis of androgen and estrogen receptors revealed a significant reduction for both offspring gonads whose rats received biological insecticides and deltamethrin, and in these same groups, testicular morphometry revealed a reduction in tubular diameter, height of seminiferous epithelium and tubular total length, and in the ovaries there was a smaller number of primary, secondary and corpus luteum follicles, and an increase in the number of tertiary and atretic follicles. The administration of insecticides also reduced the levels of biomarkers of toxicity alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine, and the biological insecticides promoted histopathological changes in the liver, with the presence of portal vein, centrilobular and sinusoid capillaries congestion, and in the kidney, presence of cortical congestion and reduction of the subcapsular space. There was a significant reduction in glycogen in the liver, and the morphometry revealed a reduction in the lobular parenchyma and an increase in the non-lobular parenchyma, while in the kidney there was a reduction in the diameter and volume of the glomerulus and Bowman's capsule in the offspring of the rats treated with the insecticides. Thus, it is concluded that both the biological insecticides XenTari® and Dipel®, as well as the synthetic insecticide deltamethrin, in sublethal doses in pregnant rats, promote reproductive, hepatic and renal changes, and in the development of the puppies, being which last until the adult phase, most of these effects were even more expressive in the groups that received biological insecticides.Devido à utilização em larga escala, os inseticidas estão entre os fatores de risco mais importantes para a saúde do homem, animais e meio ambiente. Como alternativa ao uso de inseticidas químicos, os bioinseticidas à base das proteínas Cry de Bacillus thuringiensis são uma estratégia significativa e muito utilizada contra insetos praga. Porém, apesar destas proteínas serem consideradas seguras para vertebrados, estudos tem apresentado resultados que discordam dessa afirmação. Sendo assim, esta pesquisa se propõe a investigar os possíveis efeitos na morfofisiologia reprodutiva, hepática e renal, em filhotes de ratas que receberam os inseticidas biológicos XenTari® WG e Dipel® durante prenhez e lactação. Foram utilizadas 20 ratas, Rattus norvegicus albinus da linhagem Wistar com 90 dias de idade, acasaladas e divididas nos seguintes grupos: GC – Ratas prenhes; GX – Ratas prenhes que receberam XenTari® WG (B. thuringiensis subsp. Aizawai); GDi – Ratas prenhes que receberam Dipel® (B. thuringiensis var. Kurstaki); e GDe – Ratas prenhes que receberam deltametrina (Keshet® 25EC). A administração dos inseticidas foi realizada por gavagem, na dosagem de 1mg/100g/dia (Grupos GX e GDi), e 2mg/Kg/dia (Grupo GDe), durante toda a gestação e lactação. Os resultados revelaram que a administração dos inseticidas biológicos e sintético reduziu o ganho de peso das matrizes quando comparados ao grupo controle. Os inseticidas biológicos também promoveram redução da prole, do peso, do comprimento, causaram malformação e mortalidade. Houve retardo no período de abertura vaginal, aumento do metaestro em relação as outras fases, redução do estrógeno, progesterona (fêmeas) e testosterona (machos), ovários com numerosos folículos terciários, atrésicos e poucos corpos lúteos na prole dos três grupos que receberam inseticidas e, apenas nos grupos XenTari® e Dipel® foi observado alterações histopatológicas nos testículos, com vacuolizações e descamação do epitélio seminífero. A análise quantitativa dos receptores de andrógeno e estrógeno revelou redução significativa para ambos nas gônadas da prole cujas ratas receberam os inseticidas biológicos e a deltametrina e, nestes mesmos grupos, a morfometria testicular revelou redução do diâmetro tubular, da altura do epitélio seminífero e do comprimento total tubular, e nos ovários observou-se menor número de folículos primários, secundários e corpos lúteos, e aumento no número de folículos terciários e atrésicos. A administração dos inseticidas também reduziu os níveis dos biomarcadores de toxicidade alanina aminotransferase (ALT), aspartato aminotransferase (AST), ureia e creatinina, e os inseticidas biológicos promoveram alterações histopatológicas no fígado, com a presença de congestão de veia porta, centrolobular e nos capilares sinusóides, e no rim presença de congestão cortical e redução do espaço subcapsular. Houve redução significativa de glicogênio no fígado, e a morfometria revelou redução do parênquima lobular e aumento no parênquima não lobular, enquanto no rim observou-se redução do diâmetro e volume do glomérulo e da cápsula de Bowman na prole das ratas tratadas com os inseticidas. Assim, conclui-se que tanto os inseticidas biológicos XenTari® e Dipel®, quanto o inseticida sintético deltametrina, em doses subletais em ratas prenhes, promovem alterações reprodutivas, hepáticas, renais, e no desenvolvimento dos filhotes, que se prolongam até a fase adulta, sendo a maioria desses efeitos ainda mais expressivos nos grupos que receberam os inseticidas biológicos.Submitted by (ana.araujo@ufrpe.br) on 2024-07-22T14:10:16Z No. of bitstreams: 1 Rebeka da Costa Alves.pdf: 4905338 bytes, checksum: ee2c7ae7e0e13404e3209339a76b3714 (MD5)Made available in DSpace on 2024-07-22T14:10:16Z (GMT). No. of bitstreams: 1 Rebeka da Costa Alves.pdf: 4905338 bytes, checksum: ee2c7ae7e0e13404e3209339a76b3714 (MD5) Previous issue date: 2020-02-19application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em Biociência AnimalUFRPEBrasilDepartamento de Morfologia e Fisiologia AnimalInseticidas biológicosBacillus thuringiensisToxicidadeCIENCIAS AGRARIAS::MEDICINA VETERINARIAEfeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistarinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-1510757014399315592600600600-8922364187987396204453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPEORIGINALRebeka da Costa Alves.pdfRebeka da Costa Alves.pdfapplication/pdf4905338http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/9677/2/Rebeka+da+Costa+Alves.pdfee2c7ae7e0e13404e3209339a76b3714MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/9677/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede2/96772024-07-22 11:10:16.895oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-07-22T14:10:16Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false |
dc.title.por.fl_str_mv |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
title |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
spellingShingle |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar ALVES, Rebeka da Costa Inseticidas biológicos Bacillus thuringiensis Toxicidade CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
title_full |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
title_fullStr |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
title_full_unstemmed |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
title_sort |
Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar |
author |
ALVES, Rebeka da Costa |
author_facet |
ALVES, Rebeka da Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
TEIXEIRA, Álvaro Aguiar Coelho |
dc.contributor.advisor-co1.fl_str_mv |
TEIXEIRA, Valéria Wanderley |
dc.contributor.referee1.fl_str_mv |
MELO, Ismaela Maria Ferreira de |
dc.contributor.referee2.fl_str_mv |
JORDÃO, Ana Janaína Jeanine Martins de Lemos |
dc.contributor.referee3.fl_str_mv |
SILVA JUNIOR, Valdemiro Amaro da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0700922711295090 |
dc.contributor.author.fl_str_mv |
ALVES, Rebeka da Costa |
contributor_str_mv |
TEIXEIRA, Álvaro Aguiar Coelho TEIXEIRA, Valéria Wanderley MELO, Ismaela Maria Ferreira de JORDÃO, Ana Janaína Jeanine Martins de Lemos SILVA JUNIOR, Valdemiro Amaro da |
dc.subject.por.fl_str_mv |
Inseticidas biológicos Bacillus thuringiensis Toxicidade |
topic |
Inseticidas biológicos Bacillus thuringiensis Toxicidade CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
Due to their large-scale use, insecticides are among the most important risk factors for the health of man, animals, and the environment. As an alternative to the use of chemical insecticides, bioinsecticides based on the Cry proteins of Bacillus thuringiensis are a significant and widely used strategy against insect pests. However, although these proteins are considered safe for vertebrates, studies have shown results that disagree with this statement. Therefore, this research aims to investigate the possible effects on reproductive, hepatic and renal morphophysiology in puppies of rats that received the biological insecticides XenTari® WG and Dipel® during pregnancy and lactation. Twenty rats, Rattus norvegicus albinus of the Wistar strain, 90 days old, mated and divided into the following groups were used: CG - Pregnant rats; GX - Pregnant rats that received XenTari® WG (B. thuringiensis subsp. Aizawai); GDi - Pregnant rats that received Dipel® (B. thuringiensis var. Kurstaki); and GDe - Pregnant rats that received deltamethrin (Keshet® 25EC). Insecticides were administered by gavage, at a dosage of 1mg/100g/day (Groups GX and GDi), and 2mg/Kg/day (Group GDe), throughout pregnancy and lactation. The results revealed that the administration of biological and synthetic insecticides reduced the weight gain of the matrices when compared to the control group. Biological insecticides also promoted a reduction in offspring, weight, and length, causing malformation and mortality. There was a delay in the vaginal opening period, an increase in the metestrus about the other phases, a reduction in estrogen, progesterone (females) and testosterone (males), ovaries with numerous tertiary follicles, atresia and few corpus luteum in the offspring of the three groups that received insecticides and, only in the XenTari® and Dipel® groups, histopathological changes in the testicles were observed, with vacuolations and desquamation of the seminiferous epithelium. Quantitative analysis of androgen and estrogen receptors revealed a significant reduction for both offspring gonads whose rats received biological insecticides and deltamethrin, and in these same groups, testicular morphometry revealed a reduction in tubular diameter, height of seminiferous epithelium and tubular total length, and in the ovaries there was a smaller number of primary, secondary and corpus luteum follicles, and an increase in the number of tertiary and atretic follicles. The administration of insecticides also reduced the levels of biomarkers of toxicity alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine, and the biological insecticides promoted histopathological changes in the liver, with the presence of portal vein, centrilobular and sinusoid capillaries congestion, and in the kidney, presence of cortical congestion and reduction of the subcapsular space. There was a significant reduction in glycogen in the liver, and the morphometry revealed a reduction in the lobular parenchyma and an increase in the non-lobular parenchyma, while in the kidney there was a reduction in the diameter and volume of the glomerulus and Bowman's capsule in the offspring of the rats treated with the insecticides. Thus, it is concluded that both the biological insecticides XenTari® and Dipel®, as well as the synthetic insecticide deltamethrin, in sublethal doses in pregnant rats, promote reproductive, hepatic and renal changes, and in the development of the puppies, being which last until the adult phase, most of these effects were even more expressive in the groups that received biological insecticides. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-02-19 |
dc.date.accessioned.fl_str_mv |
2024-07-22T14:10:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALVES, Rebeka da Costa. Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar. 2020. 94 f. Tese (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife. |
dc.identifier.uri.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/9677 |
identifier_str_mv |
ALVES, Rebeka da Costa. Efeitos de doses subletais de inseticidas biológicos, administrados durante prenhez e lactação, sobre aspectos reprodutivos, hepático e renal de filhotes de ratas Wistar. 2020. 94 f. Tese (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife. |
url |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/9677 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-8922364187987396204 |
dc.relation.cnpq.fl_str_mv |
453670264235017319 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal Rural de Pernambuco |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Biociência Animal |
dc.publisher.initials.fl_str_mv |
UFRPE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Departamento de Morfologia e Fisiologia Animal |
publisher.none.fl_str_mv |
Universidade Federal Rural de Pernambuco |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFRPE instname:Universidade Federal Rural de Pernambuco (UFRPE) instacron:UFRPE |
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Universidade Federal Rural de Pernambuco (UFRPE) |
instacron_str |
UFRPE |
institution |
UFRPE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFRPE |
collection |
Biblioteca Digital de Teses e Dissertações da UFRPE |
bitstream.url.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/9677/2/Rebeka+da+Costa+Alves.pdf http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/9677/1/license.txt |
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MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE) |
repository.mail.fl_str_mv |
bdtd@ufrpe.br ||bdtd@ufrpe.br |
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