Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da USC |
Texto Completo: | http://tede2.usc.br:8080/jspui/handle/tede/298 |
Resumo: | The present study aimed to evaluate the effect of the Indomethacin and the Celecoxib anti-inflammatories on the alveolar bone resorption caused by the primary occlusal trauma (OT) experimentally developed in Wistar rats, from the insertion of a unilateral occlusal interference in a lower first molar randomly chosen. Therefore, 55 animals received the treatments during a 14-day period, and were randomly divided in the following groups: Positive Control (PC) (n=15) – OT + distilled water; OT+Indomethacin (n=15); OT+Celecoxib (n=15); Negative Control (NC) (n=10) – No treatment, with the objective of obtaining baseline data. The furcal region of the inferior first molars that underwent occlusal trauma was evaluated through histometry and histochemistry. A morphometric analysis was performed to compare the degree of bone resorption in the labial surface of the first molar, in the area between the cementum-enamel junction and the mesial and distal alveolar bone crest. Histometrically, the inter-group analysis showed greater bone resorption in the OT+Celebra, OT+Indomethacin and PC compared to NC (p<0.0001) groups. There was greater bone resorption in the OT+Celebra group compared to the PC (p=1.524E-05) and OT+Indomethacin (p=0.001064) groups; there was no statistic difference in bone resorption between OT+Indomethacin x PC (p=0.2003). The intergroup histochemical analysis showed a significantly higher number of osteoclasts/mm in the OT+Celecoxib group when compared to NC (p=0.03877). The inter-group morphometric analysis showed no significant difference between the OT+Indomethacin x NC (p=0.1613) groups; however, in the comparison between the two groups, differences between OT+Celecoxib and NC (p=0.04813) and between PC and NC (p=0.01182) were verified. There was a strong positive correlation between the resorption degree and the number of TRAP-positive cells in the PC (r=0.894) and OT+Celecoxib (r=0.933) groups, as well as a low correlation in the NC (r=0.259) and OT+Indomethacin (r=0.234) groups. It could be concluded that the anti-inflammatories utilized did not contribute to bone loss reduction in the OT, considering that the Indomethacin was ineffective and the Celecoxib exacerbated the alveolar bone resorption and the number of osteoclasts resulting from the OT. |
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Campos, Mirella Lindoso Gomeshttp://lattes.cnpq.br/6478305130957187Ishikiriama, Bella Luna Colombini22401833811http://lattes.cnpq.br/965572476172991462237535272http://lattes.cnpq.br/3410619397064898Lopes, Ana Cristina Távora de Albuquerque2016-02-01T20:34:01Z2015-09-02LOPES, Ana Cristina Távora de Albuquerque. Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário. 2015. 75 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2015.http://tede2.usc.br:8080/jspui/handle/tede/298The present study aimed to evaluate the effect of the Indomethacin and the Celecoxib anti-inflammatories on the alveolar bone resorption caused by the primary occlusal trauma (OT) experimentally developed in Wistar rats, from the insertion of a unilateral occlusal interference in a lower first molar randomly chosen. Therefore, 55 animals received the treatments during a 14-day period, and were randomly divided in the following groups: Positive Control (PC) (n=15) – OT + distilled water; OT+Indomethacin (n=15); OT+Celecoxib (n=15); Negative Control (NC) (n=10) – No treatment, with the objective of obtaining baseline data. The furcal region of the inferior first molars that underwent occlusal trauma was evaluated through histometry and histochemistry. A morphometric analysis was performed to compare the degree of bone resorption in the labial surface of the first molar, in the area between the cementum-enamel junction and the mesial and distal alveolar bone crest. Histometrically, the inter-group analysis showed greater bone resorption in the OT+Celebra, OT+Indomethacin and PC compared to NC (p<0.0001) groups. There was greater bone resorption in the OT+Celebra group compared to the PC (p=1.524E-05) and OT+Indomethacin (p=0.001064) groups; there was no statistic difference in bone resorption between OT+Indomethacin x PC (p=0.2003). The intergroup histochemical analysis showed a significantly higher number of osteoclasts/mm in the OT+Celecoxib group when compared to NC (p=0.03877). The inter-group morphometric analysis showed no significant difference between the OT+Indomethacin x NC (p=0.1613) groups; however, in the comparison between the two groups, differences between OT+Celecoxib and NC (p=0.04813) and between PC and NC (p=0.01182) were verified. There was a strong positive correlation between the resorption degree and the number of TRAP-positive cells in the PC (r=0.894) and OT+Celecoxib (r=0.933) groups, as well as a low correlation in the NC (r=0.259) and OT+Indomethacin (r=0.234) groups. It could be concluded that the anti-inflammatories utilized did not contribute to bone loss reduction in the OT, considering that the Indomethacin was ineffective and the Celecoxib exacerbated the alveolar bone resorption and the number of osteoclasts resulting from the OT.O objetivo do presente estudo foi avaliar o efeito dos anti-inflamatórios Indometacina e Celecoxibe na reabsorção óssea alveolar promovida pelo trauma oclusal primário (TO) desenvolvido experimentalmente em ratos Wistar, a partir da inserção de uma interferência oclusal unilateral em um primeiro molar inferior escolhido aleatoriamente. Assim, 55 animais receberam os tratamentos por 14 dias e foram aleatoriamente divididos em um dos grupos: Controle positivo (CP) (n=15) - TO + Água destilada; TO+Indometacina (n=15); TO+Celecoxibe (n=15); Controle negativo (CN) (n=10). A região da furca dos primeiros molares inferiores submetidos ao trauma oclusal foi avaliada por meio da histometria e histoquímica. Realizou-se ainda a análise morfométrica para comparar o grau de reabsorção óssea, na face vestibular do primeiro molar, na área entre a junção cemento-esmalte e as cristas ósseas alveolares mesial e distal. Histometricamente, a análise intergrupos mostrou maior reabsorção óssea nos grupos TO+Celebra, TO+Indometacina e CP quando comparados ao CN (p<0,0001). Houve maior reabsorção óssea no grupo TO+Celebra quando comparado aos grupos CP (p=1,524E-05) e TO+Indometacina (p=0,001064) e não houve diferença estatística na reabsorção óssea entre TO+Indometacina x CP (p=0,2003). A análise histoquímica intergrupos mostrou um número significativamente maior de osteoclastos/mm no grupo TO+Celecoxibe quando comparado ao CN (p=0,03877). A análise morfométrica intergrupos não mostrou diferença significativa entre os grupos TO+Indometacina x CN (p=0,1613); porém, na comparação entre dois grupos, apontou diferença entre TO+Celecoxibe e CN (p=0,04813) e entre CP e CN (p=0,01182). Verificou-se uma forte correlação positiva entre o grau de reabsorção e o número de células TRAP-positivas, nos grupos CP (r=0,894) e TO+Celecoxibe (r=0,933) e uma correlação fraca no CN (r=0,259) e TO+Indometacina (r=0,234). Pôde-se concluir que os anti-inflamatórios utilizados não contribuíram na redução da perda óssea no TO, sendo que a Indometacina foi ineficaz e o Celecoxibe exacerbou a reabsorção óssea alveolar e o número de osteoclastos decorrente do TO.Submitted by Valquiria Tavares (valquiria.tavares@usc.br) on 2016-02-01T20:34:01Z No. of bitstreams: 1 dissertacao_ana_cristina_lopes.pdf: 789491 bytes, checksum: c2ef6f12f2b77f3d3c1289ef63218839 (MD5)Made available in DSpace on 2016-02-01T20:34:01Z (GMT). No. of bitstreams: 1 dissertacao_ana_cristina_lopes.pdf: 789491 bytes, checksum: c2ef6f12f2b77f3d3c1289ef63218839 (MD5) Previous issue date: 2015-09-02application/pdfporUniversidade do Sagrado CoraçãoBiologia OralUSCBrasilCiências da Saúde e BiológicasOclusão dentária traumáticaAnti-inflamatóriosPeriodontiaDental Occlusion, TraumaticAnti-inflammatory agentsPeriodonticsCIENCIAS DA SAUDE::ODONTOLOGIAEfeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primárioEffect of non-steroidal anti-inflammatory drugs on the alveolar bone resorption promoted by the primary occlusal traumainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8043334104093724546600600600-753428887677182963-2070498469879244349info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da USCinstname:Universidade do Sagrado Coração (USC)instacron:USCLICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/298/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALdissertacao_ana_cristina_lopes.pdfdissertacao_ana_cristina_lopes.pdfapplication/pdf789491http://localhost:8080/tede/bitstream/tede/298/2/dissertacao_ana_cristina_lopes.pdfc2ef6f12f2b77f3d3c1289ef63218839MD52tede/2982016-02-01 18:34:01.762oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede2.usc.br:8443/http://tede2.usc.br:8080/oai/requestbiblicorjesu@unisagrado.edu.br||normalizacao@usc.bropendoar:2016-02-01T20:34:01Biblioteca Digital de Teses e Dissertações da USC - Universidade do Sagrado Coração (USC)false |
dc.title.eng.fl_str_mv |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
dc.title.alternative.eng.fl_str_mv |
Effect of non-steroidal anti-inflammatory drugs on the alveolar bone resorption promoted by the primary occlusal trauma |
title |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
spellingShingle |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário Lopes, Ana Cristina Távora de Albuquerque Oclusão dentária traumática Anti-inflamatórios Periodontia Dental Occlusion, Traumatic Anti-inflammatory agents Periodontics CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
title_full |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
title_fullStr |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
title_full_unstemmed |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
title_sort |
Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário |
author |
Lopes, Ana Cristina Távora de Albuquerque |
author_facet |
Lopes, Ana Cristina Távora de Albuquerque |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Campos, Mirella Lindoso Gomes |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6478305130957187 |
dc.contributor.advisor-co1.fl_str_mv |
Ishikiriama, Bella Luna Colombini |
dc.contributor.advisor-co1ID.fl_str_mv |
22401833811 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/9655724761729914 |
dc.contributor.authorID.fl_str_mv |
62237535272 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3410619397064898 |
dc.contributor.author.fl_str_mv |
Lopes, Ana Cristina Távora de Albuquerque |
contributor_str_mv |
Campos, Mirella Lindoso Gomes Ishikiriama, Bella Luna Colombini |
dc.subject.por.fl_str_mv |
Oclusão dentária traumática Anti-inflamatórios Periodontia |
topic |
Oclusão dentária traumática Anti-inflamatórios Periodontia Dental Occlusion, Traumatic Anti-inflammatory agents Periodontics CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Dental Occlusion, Traumatic Anti-inflammatory agents Periodontics |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
The present study aimed to evaluate the effect of the Indomethacin and the Celecoxib anti-inflammatories on the alveolar bone resorption caused by the primary occlusal trauma (OT) experimentally developed in Wistar rats, from the insertion of a unilateral occlusal interference in a lower first molar randomly chosen. Therefore, 55 animals received the treatments during a 14-day period, and were randomly divided in the following groups: Positive Control (PC) (n=15) – OT + distilled water; OT+Indomethacin (n=15); OT+Celecoxib (n=15); Negative Control (NC) (n=10) – No treatment, with the objective of obtaining baseline data. The furcal region of the inferior first molars that underwent occlusal trauma was evaluated through histometry and histochemistry. A morphometric analysis was performed to compare the degree of bone resorption in the labial surface of the first molar, in the area between the cementum-enamel junction and the mesial and distal alveolar bone crest. Histometrically, the inter-group analysis showed greater bone resorption in the OT+Celebra, OT+Indomethacin and PC compared to NC (p<0.0001) groups. There was greater bone resorption in the OT+Celebra group compared to the PC (p=1.524E-05) and OT+Indomethacin (p=0.001064) groups; there was no statistic difference in bone resorption between OT+Indomethacin x PC (p=0.2003). The intergroup histochemical analysis showed a significantly higher number of osteoclasts/mm in the OT+Celecoxib group when compared to NC (p=0.03877). The inter-group morphometric analysis showed no significant difference between the OT+Indomethacin x NC (p=0.1613) groups; however, in the comparison between the two groups, differences between OT+Celecoxib and NC (p=0.04813) and between PC and NC (p=0.01182) were verified. There was a strong positive correlation between the resorption degree and the number of TRAP-positive cells in the PC (r=0.894) and OT+Celecoxib (r=0.933) groups, as well as a low correlation in the NC (r=0.259) and OT+Indomethacin (r=0.234) groups. It could be concluded that the anti-inflammatories utilized did not contribute to bone loss reduction in the OT, considering that the Indomethacin was ineffective and the Celecoxib exacerbated the alveolar bone resorption and the number of osteoclasts resulting from the OT. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-09-02 |
dc.date.accessioned.fl_str_mv |
2016-02-01T20:34:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
LOPES, Ana Cristina Távora de Albuquerque. Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário. 2015. 75 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2015. |
dc.identifier.uri.fl_str_mv |
http://tede2.usc.br:8080/jspui/handle/tede/298 |
identifier_str_mv |
LOPES, Ana Cristina Távora de Albuquerque. Efeito dos anti-inflamatórios não-esteroidais sobre a reabsorção óssea alveolar promovida pelo trauma oclusal primário. 2015. 75 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2015. |
url |
http://tede2.usc.br:8080/jspui/handle/tede/298 |
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Universidade do Sagrado Coração |
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Biologia Oral |
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USC |
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Brasil |
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Ciências da Saúde e Biológicas |
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Universidade do Sagrado Coração |
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