Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da USC |
Texto Completo: | http://tede2.usc.br:8080/jspui/handle/tede/386 |
Resumo: | The endodontic treatment aims to promote the maximum elimination of bacteria from the root canal system, however, the persistence of these microorganisms, either by previous endodontic treatment or by reinfection in the canal through microleakage, favors treatment failure. Enterococcus faecalis is the bacterial species isolated from root canals with the highest prevalence in secondary infections. It is of concern to the dental surgeon that the root canal system be thoroughly cleaned during the bio-mechanical preparation and a complete sealing with sealing cements. In order to inhibit bacterial growth, it is extremely important that the obturator materials possess antimicrobial activity so that in the filling they can confine and, if possible, eliminate the microorganisms that have adapted to the new environment. The addition of antibiotics to endodontic cements has been proposed in order to enhance the antibacterial action of the sealing materials. Therefore, the objective of this work was to evaluate the antibiofilm efficacy of the AH Plus, Sealer 26 and Endofill sealants, associated to amoxicillin, tri-antibiotic powder and diclofenac sodium, when submitted to biofilm formation by E. faecalis strain ATCC 29212. Blocks of each pure cement were made and associated with the medications with approximately 5 mm of diameter by 2 mm of thickness. For 21 days, the blocks of the cements were subjected to a culture of E. faecalis ATCC 29212. At the end of the biofilm formation, the blocks were examined by laser scanning confocal microscopy at 40X magnification in order to determine the percentage of bacterial viability. Three specimens were photographed in each group and 4 photos were taken per specimen, totaling 12 photos per group. The images were analyzed by bioImage_L software. The evaluation of the physical properties of the cements and the time of prey of the pure cements and associated with the drugs were evaluated according to ANSI / ADA standards. The association of Endofill cement associated with tri-antibiotic powder revealed better antimicrobial performance (1.011% viability) on E. faecalis biofilm ATCC 29212, followed by the combination of AH Plus with the anti-inflammatory diclofenac sodium (5.64% viability). In relation to the physical tests all the cements and their associations presented yield results within the values specified by ISO 6876 of 2012. In relation to the holding time the results were evaluated in minutes. In the test of initial prey time the pure cement Endofill was the one that presented lower average (60 min) and the association of Sealer 26 with the antibiotic amoxicillin major (922 min). In the test of final prey time the pure cement Endofill presented lower value (130 min) and cement AH Plus associated with diclofenac sodium indicated the highest values (1605 min). Therefore, as combinations of Endofill + tri-antibiotic powder and AH Plus + diclofenac sodium presented better results in relation to antimicrobial activity and adequate flow values. However, the holding time of all pure and associated cements presented values for the variation allowed by the standard 57 ANSI/ADA. Thus, future studies are needed, mainly, regarding solubility and biological behavior, these mixtures. |
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Weckwerth, Paulo Henrique10620442-7137.283.208-46http://lattes.cnpq.br/502584619843096048.803.100-x409.692.788-02http://lattes.cnpq.br/1443539308668479Freitas, Rafaela Pignatti de2018-03-21T18:28:37Z2018-01-25FREITAS, Rafaela Pignatti de. Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico. 2018. 46 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2018.http://tede2.usc.br:8080/jspui/handle/tede/386The endodontic treatment aims to promote the maximum elimination of bacteria from the root canal system, however, the persistence of these microorganisms, either by previous endodontic treatment or by reinfection in the canal through microleakage, favors treatment failure. Enterococcus faecalis is the bacterial species isolated from root canals with the highest prevalence in secondary infections. It is of concern to the dental surgeon that the root canal system be thoroughly cleaned during the bio-mechanical preparation and a complete sealing with sealing cements. In order to inhibit bacterial growth, it is extremely important that the obturator materials possess antimicrobial activity so that in the filling they can confine and, if possible, eliminate the microorganisms that have adapted to the new environment. The addition of antibiotics to endodontic cements has been proposed in order to enhance the antibacterial action of the sealing materials. Therefore, the objective of this work was to evaluate the antibiofilm efficacy of the AH Plus, Sealer 26 and Endofill sealants, associated to amoxicillin, tri-antibiotic powder and diclofenac sodium, when submitted to biofilm formation by E. faecalis strain ATCC 29212. Blocks of each pure cement were made and associated with the medications with approximately 5 mm of diameter by 2 mm of thickness. For 21 days, the blocks of the cements were subjected to a culture of E. faecalis ATCC 29212. At the end of the biofilm formation, the blocks were examined by laser scanning confocal microscopy at 40X magnification in order to determine the percentage of bacterial viability. Three specimens were photographed in each group and 4 photos were taken per specimen, totaling 12 photos per group. The images were analyzed by bioImage_L software. The evaluation of the physical properties of the cements and the time of prey of the pure cements and associated with the drugs were evaluated according to ANSI / ADA standards. The association of Endofill cement associated with tri-antibiotic powder revealed better antimicrobial performance (1.011% viability) on E. faecalis biofilm ATCC 29212, followed by the combination of AH Plus with the anti-inflammatory diclofenac sodium (5.64% viability). In relation to the physical tests all the cements and their associations presented yield results within the values specified by ISO 6876 of 2012. In relation to the holding time the results were evaluated in minutes. In the test of initial prey time the pure cement Endofill was the one that presented lower average (60 min) and the association of Sealer 26 with the antibiotic amoxicillin major (922 min). In the test of final prey time the pure cement Endofill presented lower value (130 min) and cement AH Plus associated with diclofenac sodium indicated the highest values (1605 min). Therefore, as combinations of Endofill + tri-antibiotic powder and AH Plus + diclofenac sodium presented better results in relation to antimicrobial activity and adequate flow values. However, the holding time of all pure and associated cements presented values for the variation allowed by the standard 57 ANSI/ADA. Thus, future studies are needed, mainly, regarding solubility and biological behavior, these mixtures.O tratamento endodôntico tem como finalidade promover a eliminação máxima de bactérias do sistema de canais radiculares, entretanto a persistência desses microrganismos, seja por um tratamento endodôntico anterior ou por uma reinfecção no canal por meio de microinfiltrações, favorece o insucesso do tratamento. Enterococcus faecalis é a espécie bacteriana isolada dos canais radiculares com maior prevalência nas infecções secundárias. É de preocupação do cirurgião dentista um completo saneamento do sistema de canais radiculares durante o preparo biomecânico e um completo selamento com cimentos obturadores. Para inibir o crescimento bacteriano é extremamente importante que os materiais obturadores possuam atividade antimicrobiana para que na obturação possam confinar, e se possível, eliminar os microrganismos que, se adaptaram ao novo ambiente. A adição de antibióticos aos cimentos endodônticos tem sido proposta a fim de intensificar a ação antibacteriana dos materiais obturadores. Diante disso, o objetivo desse trabalho foi avaliar a eficácia antibiofilme dos cimentos obturadores AH Plus, Sealer 26 e Endofill, associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico, quando submetidos à formação de biofilme por linhagem de E. faecalis ATCC 29212. Foram confeccionados blocos de cada cimento puro e associado às medicações com aproximadamente 5 mm de diâmetro por 2 mm de espessura. Durante 21 dias, os blocos dos cimentos foram submetidos a uma cultura de E. faecalis ATCC 29212. Ao final da formação do biofilme, os blocos foram examinados por microscopia confocal de varredura a laser em aumento de 40X a fim de se determinar a porcentagem de viabilidade bacteriana. Três espécimes foram fotografados em cada grupo e foram tiradas 4 fotos por espécime, totalizando 12 fotos por grupo. As imagens foram analisadas pelo software bioImage_L. A avaliação das propriedades físicas escoamento e tempo de presa dos cimentos puros e associados aos fármacos foram avaliadas obedecendo às normas da ANSI/ADA. A associação do cimento Endofill associado ao pó tri-antibiótico revelou melhor desempenho antimicrobiano (1,011% de viabilidade) sobre o biofilme de E. faecalis ATCC 29212, seguido da combinação do AH Plus com o anti-inflamatório diclofenaco sódico (5,64% de viabilidade). Em relação aos testes físicos todos os cimentos e suas associações apresentaram resultados de escoamento dentro dos valores especificados pela ISO 6876 de 2012. Em relação ao tempo de presa os resultados foram avaliados em minutos. No teste do tempo de presa inicial o cimento Endofill puro foi o que apresentou menor média (60 min) e a associação do Sealer 26 com o antibiótico amoxicilina maior (922 min). No teste de tempo de presa final o cimento Endofill puro apresentou menor valor (130 min) e o cimento AH Plus associado ao diclofenaco sódico indicou os maiores valores (1605 min). Diante disso, as associações Endofill + pó tri-antibiótico e AH Plus + diclofenaco sódico apresentaram melhores resultados em relação a atividade antimicrobiana e valores de escoamento adequados. No entanto, o tempo de presa de todos os cimentos puros e associados apresentaram valores fora da variação permitida pela norma nº57 ANSI/ADA. Assim, estudos futuros são necessários, principalmente, em relação a solubilidade e comportamento biológico destas misturas.Submitted by Laudeceia Machado (laudeceia.machado@usc.br) on 2018-03-21T18:28:37Z No. of bitstreams: 1 Atividade antibiofilme e propriedades fisicas de cimentos endodonticos associados a amoxicilina... (215215)_SUMARIO.pdf: 307437 bytes, checksum: 16370d52f43bc26d7d32065094b0f170 (MD5)Made available in DSpace on 2018-03-21T18:28:37Z (GMT). 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(215215)_SUMARIO.pdf: 307437 bytes, checksum: 16370d52f43bc26d7d32065094b0f170 (MD5) Previous issue date: 2018-01-25Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade do Sagrado CoraçãoBiologia OralUSCBrasilCiências da Saúde e BiológicasCimentos dentáriosAntibacterianosAnti-inflamatóriosBiofilmeDental CementsAnti-Bacterial AgentsAnti-Inflammatory AgentsBiofilmEnterococcus faecalisCIENCIAS DA SAUDE::ODONTOLOGIAAtividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódicoAntibiofilm activity and physical properties of endodontic cements associated with amoxicillin, tri-antibiotic powder and diclofenac sodiuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8043334104093724546600600600600-753428887677182963-20704984698792443492075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da USCinstname:Universidade do Sagrado Coração (USC)instacron:USCORIGINALAtividade antibiofilme e propriedades fisicas de cimentos endodonticos associados a amoxicilina... 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dc.title.eng.fl_str_mv |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
dc.title.alternative.eng.fl_str_mv |
Antibiofilm activity and physical properties of endodontic cements associated with amoxicillin, tri-antibiotic powder and diclofenac sodium |
title |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
spellingShingle |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico Freitas, Rafaela Pignatti de Cimentos dentários Antibacterianos Anti-inflamatórios Biofilme Dental Cements Anti-Bacterial Agents Anti-Inflammatory Agents Biofilm Enterococcus faecalis CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
title_full |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
title_fullStr |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
title_full_unstemmed |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
title_sort |
Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico |
author |
Freitas, Rafaela Pignatti de |
author_facet |
Freitas, Rafaela Pignatti de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Weckwerth, Paulo Henrique |
dc.contributor.advisor1ID.fl_str_mv |
10620442-7 137.283.208-46 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5025846198430960 |
dc.contributor.authorID.fl_str_mv |
48.803.100-x 409.692.788-02 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1443539308668479 |
dc.contributor.author.fl_str_mv |
Freitas, Rafaela Pignatti de |
contributor_str_mv |
Weckwerth, Paulo Henrique |
dc.subject.por.fl_str_mv |
Cimentos dentários Antibacterianos Anti-inflamatórios Biofilme |
topic |
Cimentos dentários Antibacterianos Anti-inflamatórios Biofilme Dental Cements Anti-Bacterial Agents Anti-Inflammatory Agents Biofilm Enterococcus faecalis CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Dental Cements Anti-Bacterial Agents Anti-Inflammatory Agents Biofilm Enterococcus faecalis |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
The endodontic treatment aims to promote the maximum elimination of bacteria from the root canal system, however, the persistence of these microorganisms, either by previous endodontic treatment or by reinfection in the canal through microleakage, favors treatment failure. Enterococcus faecalis is the bacterial species isolated from root canals with the highest prevalence in secondary infections. It is of concern to the dental surgeon that the root canal system be thoroughly cleaned during the bio-mechanical preparation and a complete sealing with sealing cements. In order to inhibit bacterial growth, it is extremely important that the obturator materials possess antimicrobial activity so that in the filling they can confine and, if possible, eliminate the microorganisms that have adapted to the new environment. The addition of antibiotics to endodontic cements has been proposed in order to enhance the antibacterial action of the sealing materials. Therefore, the objective of this work was to evaluate the antibiofilm efficacy of the AH Plus, Sealer 26 and Endofill sealants, associated to amoxicillin, tri-antibiotic powder and diclofenac sodium, when submitted to biofilm formation by E. faecalis strain ATCC 29212. Blocks of each pure cement were made and associated with the medications with approximately 5 mm of diameter by 2 mm of thickness. For 21 days, the blocks of the cements were subjected to a culture of E. faecalis ATCC 29212. At the end of the biofilm formation, the blocks were examined by laser scanning confocal microscopy at 40X magnification in order to determine the percentage of bacterial viability. Three specimens were photographed in each group and 4 photos were taken per specimen, totaling 12 photos per group. The images were analyzed by bioImage_L software. The evaluation of the physical properties of the cements and the time of prey of the pure cements and associated with the drugs were evaluated according to ANSI / ADA standards. The association of Endofill cement associated with tri-antibiotic powder revealed better antimicrobial performance (1.011% viability) on E. faecalis biofilm ATCC 29212, followed by the combination of AH Plus with the anti-inflammatory diclofenac sodium (5.64% viability). In relation to the physical tests all the cements and their associations presented yield results within the values specified by ISO 6876 of 2012. In relation to the holding time the results were evaluated in minutes. In the test of initial prey time the pure cement Endofill was the one that presented lower average (60 min) and the association of Sealer 26 with the antibiotic amoxicillin major (922 min). In the test of final prey time the pure cement Endofill presented lower value (130 min) and cement AH Plus associated with diclofenac sodium indicated the highest values (1605 min). Therefore, as combinations of Endofill + tri-antibiotic powder and AH Plus + diclofenac sodium presented better results in relation to antimicrobial activity and adequate flow values. However, the holding time of all pure and associated cements presented values for the variation allowed by the standard 57 ANSI/ADA. Thus, future studies are needed, mainly, regarding solubility and biological behavior, these mixtures. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-03-21T18:28:37Z |
dc.date.issued.fl_str_mv |
2018-01-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, Rafaela Pignatti de. Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico. 2018. 46 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2018. |
dc.identifier.uri.fl_str_mv |
http://tede2.usc.br:8080/jspui/handle/tede/386 |
identifier_str_mv |
FREITAS, Rafaela Pignatti de. Atividade antibiofilme e propriedades físicas de cimentos endodônticos associados à amoxicilina, pó tri-antibiótico e diclofenaco sódico. 2018. 46 f. Dissertação (Mestrado em Biologia Oral) - Universidade do Sagrado Coração, Bauru, 2018. |
url |
http://tede2.usc.br:8080/jspui/handle/tede/386 |
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por |
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por |
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8043334104093724546 |
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600 600 600 600 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Sagrado Coração |
dc.publisher.program.fl_str_mv |
Biologia Oral |
dc.publisher.initials.fl_str_mv |
USC |
dc.publisher.country.fl_str_mv |
Brasil |
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Ciências da Saúde e Biológicas |
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Universidade do Sagrado Coração |
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Biblioteca Digital de Teses e Dissertações da USC |
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MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da USC - Universidade do Sagrado Coração (USC) |
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biblicorjesu@unisagrado.edu.br||normalizacao@usc.br |
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