Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis

Detalhes bibliográficos
Autor(a) principal: Bianch,Fabio José
Data de Publicação: 2007
Outros Autores: Oliveira,Tiago Franco de, Saito,Cristiane Borges Pereira, Peres,Regina Célia Rocha, Line,Sérgio Roberto Peres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572007000500002
Resumo: PURPOSE: Hypodontia is the congenital absence of one or more (up to six) permanent and/or deciduous teeth, being one of the most common alterations of the human dentition. Genetic polymorphisms are variations of DNA sequences occurring in a population. This study investigated whether G-915C single nucleotide polymorphism (SNPs) in the PAX9 gene promoter is associated with hypodontia in humans. MATERIAL AND METHODS: The polymorphism in region G/C-915 of PAX9 gene (NCBI ref SNP ID: rs 2073247) of 240 patients was analyzed, being 110 controls and 130 individuals with third molar agenesis. After DNA extraction, the region of interest was amplified by PCR technique using two different primers. The significance of the differences in observed frequencies of polymorphisms in both groups was assessed by odds-ratio and chi-squared test with 95% confidence interval. RESULTS: Genotype CC was more frequent in patients with agenesis (11.5%) compared to the control (1.8%), while GG was more prevalent in the control group (39.1%) compared to the individuals with agenesis (26.2%). CONCLUSION: These data showed that the allele C could be associated with the third molar agenesis.
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spelling Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesisHypodontiaPAX9 transcription factorTooth abnormalitiesGenetic polymorphismPURPOSE: Hypodontia is the congenital absence of one or more (up to six) permanent and/or deciduous teeth, being one of the most common alterations of the human dentition. Genetic polymorphisms are variations of DNA sequences occurring in a population. This study investigated whether G-915C single nucleotide polymorphism (SNPs) in the PAX9 gene promoter is associated with hypodontia in humans. MATERIAL AND METHODS: The polymorphism in region G/C-915 of PAX9 gene (NCBI ref SNP ID: rs 2073247) of 240 patients was analyzed, being 110 controls and 130 individuals with third molar agenesis. After DNA extraction, the region of interest was amplified by PCR technique using two different primers. The significance of the differences in observed frequencies of polymorphisms in both groups was assessed by odds-ratio and chi-squared test with 95% confidence interval. RESULTS: Genotype CC was more frequent in patients with agenesis (11.5%) compared to the control (1.8%), while GG was more prevalent in the control group (39.1%) compared to the individuals with agenesis (26.2%). CONCLUSION: These data showed that the allele C could be associated with the third molar agenesis.Faculdade De Odontologia De Bauru - USP2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572007000500002Journal of Applied Oral Science v.15 n.5 2007reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572007000500002info:eu-repo/semantics/openAccessBianch,Fabio JoséOliveira,Tiago Franco deSaito,Cristiane Borges PereiraPeres,Regina Célia RochaLine,Sérgio Roberto Pereseng2007-11-06T00:00:00Zoai:scielo:S1678-77572007000500002Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2007-11-06T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
title Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
spellingShingle Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
Bianch,Fabio José
Hypodontia
PAX9 transcription factor
Tooth abnormalities
Genetic polymorphism
title_short Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
title_full Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
title_fullStr Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
title_full_unstemmed Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
title_sort Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis
author Bianch,Fabio José
author_facet Bianch,Fabio José
Oliveira,Tiago Franco de
Saito,Cristiane Borges Pereira
Peres,Regina Célia Rocha
Line,Sérgio Roberto Peres
author_role author
author2 Oliveira,Tiago Franco de
Saito,Cristiane Borges Pereira
Peres,Regina Célia Rocha
Line,Sérgio Roberto Peres
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bianch,Fabio José
Oliveira,Tiago Franco de
Saito,Cristiane Borges Pereira
Peres,Regina Célia Rocha
Line,Sérgio Roberto Peres
dc.subject.por.fl_str_mv Hypodontia
PAX9 transcription factor
Tooth abnormalities
Genetic polymorphism
topic Hypodontia
PAX9 transcription factor
Tooth abnormalities
Genetic polymorphism
description PURPOSE: Hypodontia is the congenital absence of one or more (up to six) permanent and/or deciduous teeth, being one of the most common alterations of the human dentition. Genetic polymorphisms are variations of DNA sequences occurring in a population. This study investigated whether G-915C single nucleotide polymorphism (SNPs) in the PAX9 gene promoter is associated with hypodontia in humans. MATERIAL AND METHODS: The polymorphism in region G/C-915 of PAX9 gene (NCBI ref SNP ID: rs 2073247) of 240 patients was analyzed, being 110 controls and 130 individuals with third molar agenesis. After DNA extraction, the region of interest was amplified by PCR technique using two different primers. The significance of the differences in observed frequencies of polymorphisms in both groups was assessed by odds-ratio and chi-squared test with 95% confidence interval. RESULTS: Genotype CC was more frequent in patients with agenesis (11.5%) compared to the control (1.8%), while GG was more prevalent in the control group (39.1%) compared to the individuals with agenesis (26.2%). CONCLUSION: These data showed that the allele C could be associated with the third molar agenesis.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572007000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572007000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572007000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.15 n.5 2007
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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