Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/3844 |
Resumo: | OBJECTIVES: This study evaluated the resistance to antimicrobials of aerobes and facultative anaerobes isolated from patients wearing complete dentures, patients with gingivitis and periodontitis, and periodontally health subjects. MATERIAL AND METHODS: Three hundred and four isolates were tested. The minimal inhibitory concentrations of the drugs were evaluated through the agar dilution method using Mueller-Hinton agar. RESULTS: The most active antimicrobial drugs were the carbapenems (meropenem and imipenem), and resistance to these drugs was restrict to 1.6-2.3% of the isolates, as well as ciprofloxacin and rifampin. Microbial resistance to ampicillin, amoxicillin/clavulanic acid, cefoxitin, cephalothin, amikacin, chloramphenicol and nalidixic acid was particularly high. In most cases, the resistance to β-lactams was mediated by the production of hydrolytic enzymes, especially in gram-negative enteric rods, while enterococci did not evidence production of these enzymes. The association amoxicillin/clavulanic acid was not effective in 28.3% of the tested isolates. CONCLUSIONS: The results of this investigation confirmed that the oral cavity of patients with periodontitis and gingivitis, and particularly edentulous patients wearing complete dentures could harbor microorganisms with several antimicrobial resistance markers, and these microorganisms are frequently implicated in multiresistant, systemic, oral or nosocomial infections. |
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Journal of applied oral science (Online) |
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Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity PeriodontitisGingivitisBacteriaAnti-bacterial agents OBJECTIVES: This study evaluated the resistance to antimicrobials of aerobes and facultative anaerobes isolated from patients wearing complete dentures, patients with gingivitis and periodontitis, and periodontally health subjects. MATERIAL AND METHODS: Three hundred and four isolates were tested. The minimal inhibitory concentrations of the drugs were evaluated through the agar dilution method using Mueller-Hinton agar. RESULTS: The most active antimicrobial drugs were the carbapenems (meropenem and imipenem), and resistance to these drugs was restrict to 1.6-2.3% of the isolates, as well as ciprofloxacin and rifampin. Microbial resistance to ampicillin, amoxicillin/clavulanic acid, cefoxitin, cephalothin, amikacin, chloramphenicol and nalidixic acid was particularly high. In most cases, the resistance to β-lactams was mediated by the production of hydrolytic enzymes, especially in gram-negative enteric rods, while enterococci did not evidence production of these enzymes. The association amoxicillin/clavulanic acid was not effective in 28.3% of the tested isolates. CONCLUSIONS: The results of this investigation confirmed that the oral cavity of patients with periodontitis and gingivitis, and particularly edentulous patients wearing complete dentures could harbor microorganisms with several antimicrobial resistance markers, and these microorganisms are frequently implicated in multiresistant, systemic, oral or nosocomial infections. Universidade de São Paulo. Faculdade de Odontologia de Bauru2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/384410.1590/S1678-77572010000600004Journal of Applied Oral Science; Vol. 18 No. 6 (2010); 551-559 Journal of Applied Oral Science; Vol. 18 Núm. 6 (2010); 551-559 Journal of Applied Oral Science; v. 18 n. 6 (2010); 551-559 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3844/4534Copyright (c) 2010 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessGaetti-Jardim, Ellen CristinaMarqueti, Antônio CarlosFaverani, Leonardo PerezGaetti-Jardim Júnior, Elerson2012-04-27T12:11:18Zoai:revistas.usp.br:article/3844Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:11:18Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
title |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
spellingShingle |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity Gaetti-Jardim, Ellen Cristina Periodontitis Gingivitis Bacteria Anti-bacterial agents |
title_short |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
title_full |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
title_fullStr |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
title_full_unstemmed |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
title_sort |
Antimicrobial resistance of aerobes and facultative anaerobes isolated from the oral cavity |
author |
Gaetti-Jardim, Ellen Cristina |
author_facet |
Gaetti-Jardim, Ellen Cristina Marqueti, Antônio Carlos Faverani, Leonardo Perez Gaetti-Jardim Júnior, Elerson |
author_role |
author |
author2 |
Marqueti, Antônio Carlos Faverani, Leonardo Perez Gaetti-Jardim Júnior, Elerson |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gaetti-Jardim, Ellen Cristina Marqueti, Antônio Carlos Faverani, Leonardo Perez Gaetti-Jardim Júnior, Elerson |
dc.subject.por.fl_str_mv |
Periodontitis Gingivitis Bacteria Anti-bacterial agents |
topic |
Periodontitis Gingivitis Bacteria Anti-bacterial agents |
description |
OBJECTIVES: This study evaluated the resistance to antimicrobials of aerobes and facultative anaerobes isolated from patients wearing complete dentures, patients with gingivitis and periodontitis, and periodontally health subjects. MATERIAL AND METHODS: Three hundred and four isolates were tested. The minimal inhibitory concentrations of the drugs were evaluated through the agar dilution method using Mueller-Hinton agar. RESULTS: The most active antimicrobial drugs were the carbapenems (meropenem and imipenem), and resistance to these drugs was restrict to 1.6-2.3% of the isolates, as well as ciprofloxacin and rifampin. Microbial resistance to ampicillin, amoxicillin/clavulanic acid, cefoxitin, cephalothin, amikacin, chloramphenicol and nalidixic acid was particularly high. In most cases, the resistance to β-lactams was mediated by the production of hydrolytic enzymes, especially in gram-negative enteric rods, while enterococci did not evidence production of these enzymes. The association amoxicillin/clavulanic acid was not effective in 28.3% of the tested isolates. CONCLUSIONS: The results of this investigation confirmed that the oral cavity of patients with periodontitis and gingivitis, and particularly edentulous patients wearing complete dentures could harbor microorganisms with several antimicrobial resistance markers, and these microorganisms are frequently implicated in multiresistant, systemic, oral or nosocomial infections. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3844 10.1590/S1678-77572010000600004 |
url |
https://www.revistas.usp.br/jaos/article/view/3844 |
identifier_str_mv |
10.1590/S1678-77572010000600004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3844/4534 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2010 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2010 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 18 No. 6 (2010); 551-559 Journal of Applied Oral Science; Vol. 18 Núm. 6 (2010); 551-559 Journal of Applied Oral Science; v. 18 n. 6 (2010); 551-559 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221676118474752 |