The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/123007 |
Resumo: | Objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month. Results: The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE. Conclusion: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX. |
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Journal of applied oral science (Online) |
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The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate Objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month. Results: The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE. Conclusion: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX. Universidade de São Paulo. Faculdade de Odontologia de Bauru2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/12300710.1590/1678-775720160139Journal of Applied Oral Science; Vol. 24 No. 5 (2016); 423-430Journal of Applied Oral Science; Vol. 24 Núm. 5 (2016); 423-430Journal of Applied Oral Science; v. 24 n. 5 (2016); 423-4301678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/123007/119386Copyright (c) 2016 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessKuduban, OzanMazlumoglu, Muhammed RecaiKuduban, Selma DenktasErhan, ErtugrulCetin, NihalKukula, OsmanYarali, OguzhanCimen, Ferda KeskinCankaya, Murat2016-11-18T10:37:37Zoai:revistas.usp.br:article/123007Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2016-11-18T10:37:37Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
title |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
spellingShingle |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate Kuduban, Ozan |
title_short |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
title_full |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
title_fullStr |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
title_full_unstemmed |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
title_sort |
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate |
author |
Kuduban, Ozan |
author_facet |
Kuduban, Ozan Mazlumoglu, Muhammed Recai Kuduban, Selma Denktas Erhan, Ertugrul Cetin, Nihal Kukula, Osman Yarali, Oguzhan Cimen, Ferda Keskin Cankaya, Murat |
author_role |
author |
author2 |
Mazlumoglu, Muhammed Recai Kuduban, Selma Denktas Erhan, Ertugrul Cetin, Nihal Kukula, Osman Yarali, Oguzhan Cimen, Ferda Keskin Cankaya, Murat |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kuduban, Ozan Mazlumoglu, Muhammed Recai Kuduban, Selma Denktas Erhan, Ertugrul Cetin, Nihal Kukula, Osman Yarali, Oguzhan Cimen, Ferda Keskin Cankaya, Murat |
description |
Objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month. Results: The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE. Conclusion: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/123007 10.1590/1678-775720160139 |
url |
https://www.revistas.usp.br/jaos/article/view/123007 |
identifier_str_mv |
10.1590/1678-775720160139 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/123007/119386 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 24 No. 5 (2016); 423-430 Journal of Applied Oral Science; Vol. 24 Núm. 5 (2016); 423-430 Journal of Applied Oral Science; v. 24 n. 5 (2016); 423-430 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221679677341696 |