Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry

Detalhes bibliográficos
Autor(a) principal: Crivelini, Marcelo Macedo
Data de Publicação: 2005
Outros Autores: Soubhia, Ana Maria Pires, Felipini, Renata Callestini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3316
Resumo: The adenomatoid odontogenic tumor (AOT) is a clinically benign lesion. Discussions about the AOT hamartomatous or neoplastic nature, and the probable odontogenic epithelial cell it originates from still exist. This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium. The results have shown that CK14 labelling indicated differentiation grades for secreting ameloblasts or ameloblasts in the post-secreting stage in the adenomatoid structure of AOT. Laminin, found on the luminal surface of adenomatoid structures, was compatible with the reduced enamel epithelium during the "protective stage of amelogenesis". PCNA specifically labelled the spindled areas and peripheral cords of the AOT, indicating that these areas are responsible for tumor growth. After considerations about pathogenesis, the authors suggested that the nature of AOT is hamartomatous with histogenesis from the reduced enamel epithelium.
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spelling Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry Estudo da origem e natureza do tumor odontogênico adenomatóide pela imunoistoquímica Neoplasias odontogênicasTumor odontogênico adenomatóideImunoistoquímicaOdontogenic neoplasmsAdenomatoid odontogenic tumorImmunohistochemistry The adenomatoid odontogenic tumor (AOT) is a clinically benign lesion. Discussions about the AOT hamartomatous or neoplastic nature, and the probable odontogenic epithelial cell it originates from still exist. This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium. The results have shown that CK14 labelling indicated differentiation grades for secreting ameloblasts or ameloblasts in the post-secreting stage in the adenomatoid structure of AOT. Laminin, found on the luminal surface of adenomatoid structures, was compatible with the reduced enamel epithelium during the "protective stage of amelogenesis". PCNA specifically labelled the spindled areas and peripheral cords of the AOT, indicating that these areas are responsible for tumor growth. After considerations about pathogenesis, the authors suggested that the nature of AOT is hamartomatous with histogenesis from the reduced enamel epithelium. O tumor odontogênico adenomatóide (TOA) é uma lesão clinicamente benigna, cujas discussões acerca de sua natureza hamartomatosa ou neoplásica, e provável célula epitelial odontogênica de origem ainda existem. Este projeto de pesquisa teve por objetivo estudar o assunto através da detecção imuno-histoquímica das citoqueratinas, laminina, colágeno IV, PCNA e p53, utilizando-se para isso 08 amostras do tumor e 08 amostras de folículo pericoronário contendo epitélio reduzido do órgão do esmalte (EROE). Os resultados mostraram que a marcação da CK14 sinalizou graus de diferenciação para ameloblastos secretores ou pós-secretores nas estruturas adenomatóides do TOA, e a laminina presente em sua superfície luminal foi compatível com o EROE durante o "estágio protetor" da amelogênese. O PCNA marcou especificamente áreas enoveladas e cordões periféricos do TOA, indicando serem estes os responsáveis pelo seu crescimento. Após considerações sobre patogênese, os autores propuseram natureza hamartomatosa e histogênese a partir do EROE para o TOA. Universidade de São Paulo. Faculdade de Odontologia de Bauru2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/331610.1590/S1678-77572005000400017Journal of Applied Oral Science; Vol. 13 No. 4 (2005); 406-412 Journal of Applied Oral Science; Vol. 13 Núm. 4 (2005); 406-412 Journal of Applied Oral Science; v. 13 n. 4 (2005); 406-412 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3316/4006Copyright (c) 2005 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCrivelini, Marcelo MacedoSoubhia, Ana Maria PiresFelipini, Renata Callestini2012-04-27T11:52:06Zoai:revistas.usp.br:article/3316Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:52:06Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
Estudo da origem e natureza do tumor odontogênico adenomatóide pela imunoistoquímica
title Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
spellingShingle Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
Crivelini, Marcelo Macedo
Neoplasias odontogênicas
Tumor odontogênico adenomatóide
Imunoistoquímica
Odontogenic neoplasms
Adenomatoid odontogenic tumor
Immunohistochemistry
title_short Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
title_full Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
title_fullStr Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
title_full_unstemmed Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
title_sort Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry
author Crivelini, Marcelo Macedo
author_facet Crivelini, Marcelo Macedo
Soubhia, Ana Maria Pires
Felipini, Renata Callestini
author_role author
author2 Soubhia, Ana Maria Pires
Felipini, Renata Callestini
author2_role author
author
dc.contributor.author.fl_str_mv Crivelini, Marcelo Macedo
Soubhia, Ana Maria Pires
Felipini, Renata Callestini
dc.subject.por.fl_str_mv Neoplasias odontogênicas
Tumor odontogênico adenomatóide
Imunoistoquímica
Odontogenic neoplasms
Adenomatoid odontogenic tumor
Immunohistochemistry
topic Neoplasias odontogênicas
Tumor odontogênico adenomatóide
Imunoistoquímica
Odontogenic neoplasms
Adenomatoid odontogenic tumor
Immunohistochemistry
description The adenomatoid odontogenic tumor (AOT) is a clinically benign lesion. Discussions about the AOT hamartomatous or neoplastic nature, and the probable odontogenic epithelial cell it originates from still exist. This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium. The results have shown that CK14 labelling indicated differentiation grades for secreting ameloblasts or ameloblasts in the post-secreting stage in the adenomatoid structure of AOT. Laminin, found on the luminal surface of adenomatoid structures, was compatible with the reduced enamel epithelium during the "protective stage of amelogenesis". PCNA specifically labelled the spindled areas and peripheral cords of the AOT, indicating that these areas are responsible for tumor growth. After considerations about pathogenesis, the authors suggested that the nature of AOT is hamartomatous with histogenesis from the reduced enamel epithelium.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3316
10.1590/S1678-77572005000400017
url https://www.revistas.usp.br/jaos/article/view/3316
identifier_str_mv 10.1590/S1678-77572005000400017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3316/4006
dc.rights.driver.fl_str_mv Copyright (c) 2005 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2005 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 13 No. 4 (2005); 406-412
Journal of Applied Oral Science; Vol. 13 Núm. 4 (2005); 406-412
Journal of Applied Oral Science; v. 13 n. 4 (2005); 406-412
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1800221672145420288

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