Systemic effect of mineral aggregate-based cements: histopathological analysis in rats

Detalhes bibliográficos
Autor(a) principal: Garcia, Lucas da Fonseca Roberti
Data de Publicação: 2017
Outros Autores: Huck, Claudia, Magalhães, Fernando Augusto Cintra, Souza, Pedro Paulo Chaves de, Souza Costa, Carlos Alberto de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/142421
Resumo: Objective: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. Material and Methods: Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats. After 7 and 30 d, samples of subcutaneous, liver and kidney tissues were submitted to histopathological analysis. A score (0-3) was used to grade the inflammatory reaction. Blood samples were collected to evaluate changes in hepatic and renal functions of animals. Results: The moderate inflammatory reaction (2) observed for 7 d in the subcutaneous tissue decreased with time for all cements. The thickness of inflammatory capsules also presented a significant decrease with time (P
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spelling Systemic effect of mineral aggregate-based cements: histopathological analysis in ratsEndodonticsBiocompatible materialsInflammationLiverKidney Objective: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. Material and Methods: Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats. After 7 and 30 d, samples of subcutaneous, liver and kidney tissues were submitted to histopathological analysis. A score (0-3) was used to grade the inflammatory reaction. Blood samples were collected to evaluate changes in hepatic and renal functions of animals. Results: The moderate inflammatory reaction (2) observed for 7 d in the subcutaneous tissue decreased with time for all cements. The thickness of inflammatory capsules also presented a significant decrease with time (PUniversidade de São Paulo. Faculdade de Odontologia de Bauru2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/14242110.1590/1678-7757-2016-0634Journal of Applied Oral Science; Vol. 25 No. 6 (2017); 620-630Journal of Applied Oral Science; Vol. 25 Núm. 6 (2017); 620-630Journal of Applied Oral Science; v. 25 n. 6 (2017); 620-6301678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/142421/137530Copyright (c) 2017 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessGarcia, Lucas da Fonseca RobertiHuck, ClaudiaMagalhães, Fernando Augusto CintraSouza, Pedro Paulo Chaves deSouza Costa, Carlos Alberto de2018-01-18T16:07:28Zoai:revistas.usp.br:article/142421Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2018-01-18T16:07:28Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
title Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
spellingShingle Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
Garcia, Lucas da Fonseca Roberti
Endodontics
Biocompatible materials
Inflammation
Liver
Kidney
title_short Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
title_full Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
title_fullStr Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
title_full_unstemmed Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
title_sort Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
author Garcia, Lucas da Fonseca Roberti
author_facet Garcia, Lucas da Fonseca Roberti
Huck, Claudia
Magalhães, Fernando Augusto Cintra
Souza, Pedro Paulo Chaves de
Souza Costa, Carlos Alberto de
author_role author
author2 Huck, Claudia
Magalhães, Fernando Augusto Cintra
Souza, Pedro Paulo Chaves de
Souza Costa, Carlos Alberto de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Garcia, Lucas da Fonseca Roberti
Huck, Claudia
Magalhães, Fernando Augusto Cintra
Souza, Pedro Paulo Chaves de
Souza Costa, Carlos Alberto de
dc.subject.por.fl_str_mv Endodontics
Biocompatible materials
Inflammation
Liver
Kidney
topic Endodontics
Biocompatible materials
Inflammation
Liver
Kidney
description Objective: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. Material and Methods: Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats. After 7 and 30 d, samples of subcutaneous, liver and kidney tissues were submitted to histopathological analysis. A score (0-3) was used to grade the inflammatory reaction. Blood samples were collected to evaluate changes in hepatic and renal functions of animals. Results: The moderate inflammatory reaction (2) observed for 7 d in the subcutaneous tissue decreased with time for all cements. The thickness of inflammatory capsules also presented a significant decrease with time (P
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/142421
10.1590/1678-7757-2016-0634
url https://www.revistas.usp.br/jaos/article/view/142421
identifier_str_mv 10.1590/1678-7757-2016-0634
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/142421/137530
dc.rights.driver.fl_str_mv Copyright (c) 2017 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 25 No. 6 (2017); 620-630
Journal of Applied Oral Science; Vol. 25 Núm. 6 (2017); 620-630
Journal of Applied Oral Science; v. 25 n. 6 (2017); 620-630
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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