The effect of natural products in animal models of temporomandibular disorders
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/190322 |
Resumo: | Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective: This systematic review aims to summarize the natural products used in treatment of experimental models of TMD. Methodology: A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias. Results: 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers. Conclusions: 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results. |
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The effect of natural products in animal models of temporomandibular disordersTemporomandibular joint disordersBiological productSystematic reviewPreclinical drug evaluationTreatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective: This systematic review aims to summarize the natural products used in treatment of experimental models of TMD. Methodology: A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias. Results: 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers. Conclusions: 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results.Universidade de São Paulo. Faculdade de Odontologia de Bauru2021-09-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19032210.1590/1678-7757-2020-0272Journal of Applied Oral Science; Vol. 28 (2020); e20200272Journal of Applied Oral Science; Vol. 28 (2020); e20200272Journal of Applied Oral Science; v. 28 (2020); e202002721678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/190322/175724Copyright (c) 2021 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Janaíne Prata Nampo, Fernando Kenji Souza, Marilia Trindade Santana Cercato, Luana Mendonça Camargo, Enilton Aparecido 2021-09-02T14:44:36Zoai:revistas.usp.br:article/190322Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2021-09-02T14:44:36Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effect of natural products in animal models of temporomandibular disorders |
title |
The effect of natural products in animal models of temporomandibular disorders |
spellingShingle |
The effect of natural products in animal models of temporomandibular disorders Oliveira, Janaíne Prata Temporomandibular joint disorders Biological product Systematic review Preclinical drug evaluation |
title_short |
The effect of natural products in animal models of temporomandibular disorders |
title_full |
The effect of natural products in animal models of temporomandibular disorders |
title_fullStr |
The effect of natural products in animal models of temporomandibular disorders |
title_full_unstemmed |
The effect of natural products in animal models of temporomandibular disorders |
title_sort |
The effect of natural products in animal models of temporomandibular disorders |
author |
Oliveira, Janaíne Prata |
author_facet |
Oliveira, Janaíne Prata Nampo, Fernando Kenji Souza, Marilia Trindade Santana Cercato, Luana Mendonça Camargo, Enilton Aparecido |
author_role |
author |
author2 |
Nampo, Fernando Kenji Souza, Marilia Trindade Santana Cercato, Luana Mendonça Camargo, Enilton Aparecido |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Janaíne Prata Nampo, Fernando Kenji Souza, Marilia Trindade Santana Cercato, Luana Mendonça Camargo, Enilton Aparecido |
dc.subject.por.fl_str_mv |
Temporomandibular joint disorders Biological product Systematic review Preclinical drug evaluation |
topic |
Temporomandibular joint disorders Biological product Systematic review Preclinical drug evaluation |
description |
Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective: This systematic review aims to summarize the natural products used in treatment of experimental models of TMD. Methodology: A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias. Results: 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers. Conclusions: 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/190322 10.1590/1678-7757-2020-0272 |
url |
https://www.revistas.usp.br/jaos/article/view/190322 |
identifier_str_mv |
10.1590/1678-7757-2020-0272 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/190322/175724 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 28 (2020); e20200272 Journal of Applied Oral Science; Vol. 28 (2020); e20200272 Journal of Applied Oral Science; v. 28 (2020); e20200272 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221681982111744 |