Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis
Main Author: | |
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Publication Date: | 2010 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Journal of applied oral science (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000500018 |
Summary: | OBJECTIVE: Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC. METHODS: Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation. RESULTS: Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia. CONCLUSIONS: The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects. |
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Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitisDiclofenacHyaluronic acidCheilitisActinic raysOral leukoplakiaOBJECTIVE: Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC. METHODS: Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation. RESULTS: Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia. CONCLUSIONS: The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.Faculdade De Odontologia De Bauru - USP2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000500018Journal of Applied Oral Science v.18 n.5 2010reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572010000500018info:eu-repo/semantics/openAccessLima,Giana da SilveiraSilva,Gabriela Ferrari daGomes,Ana Paula NeutzlingAraújo,Lenita Maria Aver deSalum,Fernanda Gonçalveseng2010-11-05T00:00:00Zoai:scielo:S1678-77572010000500018Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2010-11-05T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
title |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
spellingShingle |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis Lima,Giana da Silveira Diclofenac Hyaluronic acid Cheilitis Actinic rays Oral leukoplakia |
title_short |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
title_full |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
title_fullStr |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
title_full_unstemmed |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
title_sort |
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis |
author |
Lima,Giana da Silveira |
author_facet |
Lima,Giana da Silveira Silva,Gabriela Ferrari da Gomes,Ana Paula Neutzling Araújo,Lenita Maria Aver de Salum,Fernanda Gonçalves |
author_role |
author |
author2 |
Silva,Gabriela Ferrari da Gomes,Ana Paula Neutzling Araújo,Lenita Maria Aver de Salum,Fernanda Gonçalves |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lima,Giana da Silveira Silva,Gabriela Ferrari da Gomes,Ana Paula Neutzling Araújo,Lenita Maria Aver de Salum,Fernanda Gonçalves |
dc.subject.por.fl_str_mv |
Diclofenac Hyaluronic acid Cheilitis Actinic rays Oral leukoplakia |
topic |
Diclofenac Hyaluronic acid Cheilitis Actinic rays Oral leukoplakia |
description |
OBJECTIVE: Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC. METHODS: Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation. RESULTS: Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia. CONCLUSIONS: The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000500018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000500018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-77572010000500018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.18 n.5 2010 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936436159086592 |