Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
DOI: | 10.1590/1678-7757-2020-0702 |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/197923 |
Resumo: | Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer. Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection. Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. For the TSCC samples, the number of DCs per area was evaluated in the intra- and peritumoral compartments. For the NTs, the quantification of DCs was evaluated in the intra- and peritonsillar compartments. HPV detection methods were determined according to the ASCO Clinical Practice Guidelines from the College of American Pathologists Guideline (2018). Results: There were fewer intratumoral CD1a+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.05). In the peritumoral compartment, there were fewer CD83+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.001). The quantification of DCs subtypes showed no statistical differences between HPV-positive and HPV-negative TSCC groups (p>0.137). Patients with HPV-positive TSCC had significantly better overall survival rate than those with HPV-negative TSCC (p=0.004). Conclusion: Tumor activity contributes to DC depletion regardless of intralesional HPV positivity. An improved prognosis has been reported in patients with HPV-positive TSCC. |
id |
USP-17_85fbd85afb3b8ae7573dc87107690c88 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/197923 |
network_acronym_str |
USP-17 |
network_name_str |
Journal of applied oral science (Online) |
spelling |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV statusPapillomaviridaeTonsillar neoplasmsDendritic cellsCD83 antigenCD1a antigenDendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer. Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection. Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. For the TSCC samples, the number of DCs per area was evaluated in the intra- and peritumoral compartments. For the NTs, the quantification of DCs was evaluated in the intra- and peritonsillar compartments. HPV detection methods were determined according to the ASCO Clinical Practice Guidelines from the College of American Pathologists Guideline (2018). Results: There were fewer intratumoral CD1a+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.05). In the peritumoral compartment, there were fewer CD83+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.001). The quantification of DCs subtypes showed no statistical differences between HPV-positive and HPV-negative TSCC groups (p>0.137). Patients with HPV-positive TSCC had significantly better overall survival rate than those with HPV-negative TSCC (p=0.004). Conclusion: Tumor activity contributes to DC depletion regardless of intralesional HPV positivity. An improved prognosis has been reported in patients with HPV-positive TSCC.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-05-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19792310.1590/1678-7757-2020-0702Journal of Applied Oral Science; Vol. 30 (2022); e20210702Journal of Applied Oral Science; Vol. 30 (2022); e20210702Journal of Applied Oral Science; v. 30 (2022); e202107021678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/197923/182080Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGama-Cuellar, Ana GuadalupeFrancisco, Ana Lúcia NoronhaScarini, João FigueiraMariano, Fernanda VivianeKowalski, Luiz PauloGondak, Rogério2022-05-17T17:29:02Zoai:revistas.usp.br:article/197923Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-05-17T17:29:02Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
title |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
spellingShingle |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status Gama-Cuellar, Ana Guadalupe Papillomaviridae Tonsillar neoplasms Dendritic cells CD83 antigen CD1a antigen Gama-Cuellar, Ana Guadalupe Papillomaviridae Tonsillar neoplasms Dendritic cells CD83 antigen CD1a antigen |
title_short |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
title_full |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
title_fullStr |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
title_full_unstemmed |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
title_sort |
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status |
author |
Gama-Cuellar, Ana Guadalupe |
author_facet |
Gama-Cuellar, Ana Guadalupe Gama-Cuellar, Ana Guadalupe Francisco, Ana Lúcia Noronha Scarini, João Figueira Mariano, Fernanda Viviane Kowalski, Luiz Paulo Gondak, Rogério Francisco, Ana Lúcia Noronha Scarini, João Figueira Mariano, Fernanda Viviane Kowalski, Luiz Paulo Gondak, Rogério |
author_role |
author |
author2 |
Francisco, Ana Lúcia Noronha Scarini, João Figueira Mariano, Fernanda Viviane Kowalski, Luiz Paulo Gondak, Rogério |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gama-Cuellar, Ana Guadalupe Francisco, Ana Lúcia Noronha Scarini, João Figueira Mariano, Fernanda Viviane Kowalski, Luiz Paulo Gondak, Rogério |
dc.subject.por.fl_str_mv |
Papillomaviridae Tonsillar neoplasms Dendritic cells CD83 antigen CD1a antigen |
topic |
Papillomaviridae Tonsillar neoplasms Dendritic cells CD83 antigen CD1a antigen |
description |
Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer. Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection. Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. For the TSCC samples, the number of DCs per area was evaluated in the intra- and peritumoral compartments. For the NTs, the quantification of DCs was evaluated in the intra- and peritonsillar compartments. HPV detection methods were determined according to the ASCO Clinical Practice Guidelines from the College of American Pathologists Guideline (2018). Results: There were fewer intratumoral CD1a+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.05). In the peritumoral compartment, there were fewer CD83+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.001). The quantification of DCs subtypes showed no statistical differences between HPV-positive and HPV-negative TSCC groups (p>0.137). Patients with HPV-positive TSCC had significantly better overall survival rate than those with HPV-negative TSCC (p=0.004). Conclusion: Tumor activity contributes to DC depletion regardless of intralesional HPV positivity. An improved prognosis has been reported in patients with HPV-positive TSCC. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/197923 10.1590/1678-7757-2020-0702 |
url |
https://www.revistas.usp.br/jaos/article/view/197923 |
identifier_str_mv |
10.1590/1678-7757-2020-0702 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/197923/182080 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 30 (2022); e20210702 Journal of Applied Oral Science; Vol. 30 (2022); e20210702 Journal of Applied Oral Science; v. 30 (2022); e20210702 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1822179109811257344 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1678-7757-2020-0702 |