Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals

Detalhes bibliográficos
Autor(a) principal: OLIVEIRA, Danila de
Data de Publicação: 2017
Outros Autores: HASSUMI, Jaqueline Suemi, GOMES-FERREIRA, Pedro Henrique da Silva, POLO, Tárik Ocon Braga, FERREIRA, Gabriel Ramalho, FAVERANI, Leonardo Perez, OKAMOTO, Roberta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/126735
Resumo: Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis. Objective The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin). Material and Methods A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level. Results Bone volume (BV) and total pore volume were higher for ALE group (P
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spelling Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis. Objective The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin). Material and Methods A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level. Results Bone volume (BV) and total pore volume were higher for ALE group (PUniversidade de São Paulo. Faculdade de Odontologia de Bauru2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/12673510.1590/1678-77572016-0165Journal of Applied Oral Science; Vol. 25 No. 1 (2017); 42-52Journal of Applied Oral Science; Vol. 25 Núm. 1 (2017); 42-52Journal of Applied Oral Science; v. 25 n. 1 (2017); 42-521678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/126735/123714Copyright (c) 2017 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessOLIVEIRA, Danila deHASSUMI, Jaqueline SuemiGOMES-FERREIRA, Pedro Henrique da SilvaPOLO, Tárik Ocon BragaFERREIRA, Gabriel RamalhoFAVERANI, Leonardo PerezOKAMOTO, Roberta2017-02-14T10:08:29Zoai:revistas.usp.br:article/126735Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2017-02-14T10:08:29Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
title Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
spellingShingle Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
OLIVEIRA, Danila de
title_short Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
title_full Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
title_fullStr Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
title_full_unstemmed Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
title_sort Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
author OLIVEIRA, Danila de
author_facet OLIVEIRA, Danila de
HASSUMI, Jaqueline Suemi
GOMES-FERREIRA, Pedro Henrique da Silva
POLO, Tárik Ocon Braga
FERREIRA, Gabriel Ramalho
FAVERANI, Leonardo Perez
OKAMOTO, Roberta
author_role author
author2 HASSUMI, Jaqueline Suemi
GOMES-FERREIRA, Pedro Henrique da Silva
POLO, Tárik Ocon Braga
FERREIRA, Gabriel Ramalho
FAVERANI, Leonardo Perez
OKAMOTO, Roberta
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv OLIVEIRA, Danila de
HASSUMI, Jaqueline Suemi
GOMES-FERREIRA, Pedro Henrique da Silva
POLO, Tárik Ocon Braga
FERREIRA, Gabriel Ramalho
FAVERANI, Leonardo Perez
OKAMOTO, Roberta
description Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis. Objective The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin). Material and Methods A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level. Results Bone volume (BV) and total pore volume were higher for ALE group (P
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/126735
10.1590/1678-77572016-0165
url https://www.revistas.usp.br/jaos/article/view/126735
identifier_str_mv 10.1590/1678-77572016-0165
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/126735/123714
dc.rights.driver.fl_str_mv Copyright (c) 2017 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 25 No. 1 (2017); 42-52
Journal of Applied Oral Science; Vol. 25 Núm. 1 (2017); 42-52
Journal of Applied Oral Science; v. 25 n. 1 (2017); 42-52
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1800221679729770496

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