Effects of budlein A on human neutrophils and lymphocytes
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271 |
Resumo: | ABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells. |
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USP-17 |
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Journal of applied oral science (Online) |
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|
spelling |
Effects of budlein A on human neutrophils and lymphocytesLactonesNeutrophilsLymphocytesABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.Faculdade De Odontologia De Bauru - USP2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271Journal of Applied Oral Science v.24 n.3 2016reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-775720150540info:eu-repo/semantics/openAccessKNOB,Carollinie DiasSILVA,MilenaGASPAROTO,Thaís HelenaOLIVEIRA,Carine ErvolinoAMÔR,Nádia GhinelliARAKAWA,Nilton SyogoCOSTA,Fernando BatistaCAMPANELLI,Ana Paulaeng2016-06-30T00:00:00Zoai:scielo:S1678-77572016000300271Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2016-06-30T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effects of budlein A on human neutrophils and lymphocytes |
title |
Effects of budlein A on human neutrophils and lymphocytes |
spellingShingle |
Effects of budlein A on human neutrophils and lymphocytes KNOB,Carollinie Dias Lactones Neutrophils Lymphocytes |
title_short |
Effects of budlein A on human neutrophils and lymphocytes |
title_full |
Effects of budlein A on human neutrophils and lymphocytes |
title_fullStr |
Effects of budlein A on human neutrophils and lymphocytes |
title_full_unstemmed |
Effects of budlein A on human neutrophils and lymphocytes |
title_sort |
Effects of budlein A on human neutrophils and lymphocytes |
author |
KNOB,Carollinie Dias |
author_facet |
KNOB,Carollinie Dias SILVA,Milena GASPAROTO,Thaís Helena OLIVEIRA,Carine Ervolino AMÔR,Nádia Ghinelli ARAKAWA,Nilton Syogo COSTA,Fernando Batista CAMPANELLI,Ana Paula |
author_role |
author |
author2 |
SILVA,Milena GASPAROTO,Thaís Helena OLIVEIRA,Carine Ervolino AMÔR,Nádia Ghinelli ARAKAWA,Nilton Syogo COSTA,Fernando Batista CAMPANELLI,Ana Paula |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
KNOB,Carollinie Dias SILVA,Milena GASPAROTO,Thaís Helena OLIVEIRA,Carine Ervolino AMÔR,Nádia Ghinelli ARAKAWA,Nilton Syogo COSTA,Fernando Batista CAMPANELLI,Ana Paula |
dc.subject.por.fl_str_mv |
Lactones Neutrophils Lymphocytes |
topic |
Lactones Neutrophils Lymphocytes |
description |
ABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-775720150540 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.24 n.3 2016 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936438990241792 |