Effects of budlein A on human neutrophils and lymphocytes

Detalhes bibliográficos
Autor(a) principal: KNOB,Carollinie Dias
Data de Publicação: 2016
Outros Autores: SILVA,Milena, GASPAROTO,Thaís Helena, OLIVEIRA,Carine Ervolino, AMÔR,Nádia Ghinelli, ARAKAWA,Nilton Syogo, COSTA,Fernando Batista, CAMPANELLI,Ana Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271
Resumo: ABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.
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spelling Effects of budlein A on human neutrophils and lymphocytesLactonesNeutrophilsLymphocytesABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.Faculdade De Odontologia De Bauru - USP2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271Journal of Applied Oral Science v.24 n.3 2016reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-775720150540info:eu-repo/semantics/openAccessKNOB,Carollinie DiasSILVA,MilenaGASPAROTO,Thaís HelenaOLIVEIRA,Carine ErvolinoAMÔR,Nádia GhinelliARAKAWA,Nilton SyogoCOSTA,Fernando BatistaCAMPANELLI,Ana Paulaeng2016-06-30T00:00:00Zoai:scielo:S1678-77572016000300271Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2016-06-30T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effects of budlein A on human neutrophils and lymphocytes
title Effects of budlein A on human neutrophils and lymphocytes
spellingShingle Effects of budlein A on human neutrophils and lymphocytes
KNOB,Carollinie Dias
Lactones
Neutrophils
Lymphocytes
title_short Effects of budlein A on human neutrophils and lymphocytes
title_full Effects of budlein A on human neutrophils and lymphocytes
title_fullStr Effects of budlein A on human neutrophils and lymphocytes
title_full_unstemmed Effects of budlein A on human neutrophils and lymphocytes
title_sort Effects of budlein A on human neutrophils and lymphocytes
author KNOB,Carollinie Dias
author_facet KNOB,Carollinie Dias
SILVA,Milena
GASPAROTO,Thaís Helena
OLIVEIRA,Carine Ervolino
AMÔR,Nádia Ghinelli
ARAKAWA,Nilton Syogo
COSTA,Fernando Batista
CAMPANELLI,Ana Paula
author_role author
author2 SILVA,Milena
GASPAROTO,Thaís Helena
OLIVEIRA,Carine Ervolino
AMÔR,Nádia Ghinelli
ARAKAWA,Nilton Syogo
COSTA,Fernando Batista
CAMPANELLI,Ana Paula
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv KNOB,Carollinie Dias
SILVA,Milena
GASPAROTO,Thaís Helena
OLIVEIRA,Carine Ervolino
AMÔR,Nádia Ghinelli
ARAKAWA,Nilton Syogo
COSTA,Fernando Batista
CAMPANELLI,Ana Paula
dc.subject.por.fl_str_mv Lactones
Neutrophils
Lymphocytes
topic Lactones
Neutrophils
Lymphocytes
description ABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000300271
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-775720150540
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.24 n.3 2016
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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