In vivo effect of fluoride combined with amoxicillin on enamel development in rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/194710 |
Resumo: | Some evidence in vitro suggested that amoxicillin and fluoride could disturb the enamel mineralization. Objective: To assess the effect of amoxicillin and of the combination of amoxicillin and fluoride on enamel mineralization in rats. Methodology: In total, 40 rats were randomly assigned to four groups: control group (CG); amoxicillin group (AG - amoxicillin (500 mg/kg/day), fluoride group (FG - fluoridated water (100 ppm -221 mg F/L), and amoxicillin + fluoride group (AFG). After 60 days, the samples were collected from plasma and tibiae and analyzed for fluoride (F) concentration. The incisors were also collected to determine the severity of fluorosis using the Dental Fluorosis by Image Analysis (DFIA) software, concentration of F, measurements of enamel thickness, and hardness. The data were analyzed by ANOVA, Tukey’s post-hoc test, or Games-Howell post-hoc test (α=0.05). Results: Enamel thickness of the incisors did not differ statistically among the groups (p=0.228). Groups exposed to fluoride (AFG and FG) have higher F concentrations in plasma, bone and teeth than those not exposed to fluoride (CG and AG). The groups showed a similar behavior in the DFIA and hardness test, with the FG and AFG groups showing more severe fluorosis defects and significant lower hardness when compared with the AG and CG groups, with no difference from each other. Conclusion: The rats exposed to fluoride or fluoride + amoxicillin developed dental fluorosis, while exposure to amoxicillin alone did not lead to enamel defects. |
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Journal of applied oral science (Online) |
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In vivo effect of fluoride combined with amoxicillin on enamel development in ratsDental fluorosisRatsAmoxicillinEnamel defectSome evidence in vitro suggested that amoxicillin and fluoride could disturb the enamel mineralization. Objective: To assess the effect of amoxicillin and of the combination of amoxicillin and fluoride on enamel mineralization in rats. Methodology: In total, 40 rats were randomly assigned to four groups: control group (CG); amoxicillin group (AG - amoxicillin (500 mg/kg/day), fluoride group (FG - fluoridated water (100 ppm -221 mg F/L), and amoxicillin + fluoride group (AFG). After 60 days, the samples were collected from plasma and tibiae and analyzed for fluoride (F) concentration. The incisors were also collected to determine the severity of fluorosis using the Dental Fluorosis by Image Analysis (DFIA) software, concentration of F, measurements of enamel thickness, and hardness. The data were analyzed by ANOVA, Tukey’s post-hoc test, or Games-Howell post-hoc test (α=0.05). Results: Enamel thickness of the incisors did not differ statistically among the groups (p=0.228). Groups exposed to fluoride (AFG and FG) have higher F concentrations in plasma, bone and teeth than those not exposed to fluoride (CG and AG). The groups showed a similar behavior in the DFIA and hardness test, with the FG and AFG groups showing more severe fluorosis defects and significant lower hardness when compared with the AG and CG groups, with no difference from each other. Conclusion: The rats exposed to fluoride or fluoride + amoxicillin developed dental fluorosis, while exposure to amoxicillin alone did not lead to enamel defects.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19471010.1590/1678-7757-2021-0171 Journal of Applied Oral Science; Vol. 29 (2021); e20210171Journal of Applied Oral Science; Vol. 29 (2021); e20210171Journal of Applied Oral Science; v. 29 (2021); e202101711678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/194710/179930Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFeltrin-Souza , Juliana Costa, Silas Alves daBussaneli , Diego Girotto Santos-Pinto , Lourdes Cerri , Paulo Sérgio Cury, Jaime Tenuta , Livia Cordeiro, Rita de Cássia Loiola 2022-02-07T17:35:59Zoai:revistas.usp.br:article/194710Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-02-07T17:35:59Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
title |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
spellingShingle |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats Feltrin-Souza , Juliana Dental fluorosis Rats Amoxicillin Enamel defect |
title_short |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
title_full |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
title_fullStr |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
title_full_unstemmed |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
title_sort |
In vivo effect of fluoride combined with amoxicillin on enamel development in rats |
author |
Feltrin-Souza , Juliana |
author_facet |
Feltrin-Souza , Juliana Costa, Silas Alves da Bussaneli , Diego Girotto Santos-Pinto , Lourdes Cerri , Paulo Sérgio Cury, Jaime Tenuta , Livia Cordeiro, Rita de Cássia Loiola |
author_role |
author |
author2 |
Costa, Silas Alves da Bussaneli , Diego Girotto Santos-Pinto , Lourdes Cerri , Paulo Sérgio Cury, Jaime Tenuta , Livia Cordeiro, Rita de Cássia Loiola |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Feltrin-Souza , Juliana Costa, Silas Alves da Bussaneli , Diego Girotto Santos-Pinto , Lourdes Cerri , Paulo Sérgio Cury, Jaime Tenuta , Livia Cordeiro, Rita de Cássia Loiola |
dc.subject.por.fl_str_mv |
Dental fluorosis Rats Amoxicillin Enamel defect |
topic |
Dental fluorosis Rats Amoxicillin Enamel defect |
description |
Some evidence in vitro suggested that amoxicillin and fluoride could disturb the enamel mineralization. Objective: To assess the effect of amoxicillin and of the combination of amoxicillin and fluoride on enamel mineralization in rats. Methodology: In total, 40 rats were randomly assigned to four groups: control group (CG); amoxicillin group (AG - amoxicillin (500 mg/kg/day), fluoride group (FG - fluoridated water (100 ppm -221 mg F/L), and amoxicillin + fluoride group (AFG). After 60 days, the samples were collected from plasma and tibiae and analyzed for fluoride (F) concentration. The incisors were also collected to determine the severity of fluorosis using the Dental Fluorosis by Image Analysis (DFIA) software, concentration of F, measurements of enamel thickness, and hardness. The data were analyzed by ANOVA, Tukey’s post-hoc test, or Games-Howell post-hoc test (α=0.05). Results: Enamel thickness of the incisors did not differ statistically among the groups (p=0.228). Groups exposed to fluoride (AFG and FG) have higher F concentrations in plasma, bone and teeth than those not exposed to fluoride (CG and AG). The groups showed a similar behavior in the DFIA and hardness test, with the FG and AFG groups showing more severe fluorosis defects and significant lower hardness when compared with the AG and CG groups, with no difference from each other. Conclusion: The rats exposed to fluoride or fluoride + amoxicillin developed dental fluorosis, while exposure to amoxicillin alone did not lead to enamel defects. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/194710 10.1590/1678-7757-2021-0171 |
url |
https://www.revistas.usp.br/jaos/article/view/194710 |
identifier_str_mv |
10.1590/1678-7757-2021-0171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/194710/179930 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 29 (2021); e20210171 Journal of Applied Oral Science; Vol. 29 (2021); e20210171 Journal of Applied Oral Science; v. 29 (2021); e20210171 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221682532614144 |