Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/216967 |
Resumo: | Background: Genetic polymorphisms have been shown to influence several physiological traits, including dental and craniofacial characteristics. Understanding the clinical relevance of genetic polymorphisms in dental practice is crucial to personalize treatment plans and improve treatment outcomes. Objective: to evaluate the association between dental age and genetic polymorphisms in genes encoding estrogen receptors alpha and beta (ESR1 and ESR2, respectively) in a sample of Brazilian children. Methodology: This retrospective cross-sectional study was performed with children undergoing orthodontic treatment. Patients with syndromes, congenital anomalies, craniofacial deformities, under hormonal or systemic treatment, and with a previous history of facial trauma were excluded. Panoramic radiographs were used to assess dental age according to the Demirjian, Goldstein, and Tanner method. A delta [dental age-chronological age (DA-CA)] was obtained, which shows whether the patient tends to have a normal, delayed (negative values), or advanced (positive values) dental age. DNA isolated from buccal cells was used to genotype four genetic polymorphisms: rs9340799 (A>G) and rs2234693 (C>T), located in ESR1; and rs1256049 (C>T) and rs4986938 (C>T), located in ESR2. A statistical analysis was performed and values of p<0.05 indicated statistical difference. Results: A total of 79 patients were included, 44 (55.70%) girls and 35 (44.30%) boys. The Demirjian, Goldstein, and Tanner method, in general, overestimated patients’ age by 0.75 years. There was no difference in the delta of dental age between the sexes (p>0.05). Genetic polymorphisms in ESR1 and ESR2 were not associated with dental age (p>0.05). Conclusion: The studied genetic polymorphisms in ESR1 and ESR2 were not associated with dental age in Brazilian children |
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Journal of applied oral science (Online) |
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Investigating the association between dental age and polymorphisms in genes encoding estrogen receptorsOdontogenesisEstrogenGenesBackground: Genetic polymorphisms have been shown to influence several physiological traits, including dental and craniofacial characteristics. Understanding the clinical relevance of genetic polymorphisms in dental practice is crucial to personalize treatment plans and improve treatment outcomes. Objective: to evaluate the association between dental age and genetic polymorphisms in genes encoding estrogen receptors alpha and beta (ESR1 and ESR2, respectively) in a sample of Brazilian children. Methodology: This retrospective cross-sectional study was performed with children undergoing orthodontic treatment. Patients with syndromes, congenital anomalies, craniofacial deformities, under hormonal or systemic treatment, and with a previous history of facial trauma were excluded. Panoramic radiographs were used to assess dental age according to the Demirjian, Goldstein, and Tanner method. A delta [dental age-chronological age (DA-CA)] was obtained, which shows whether the patient tends to have a normal, delayed (negative values), or advanced (positive values) dental age. DNA isolated from buccal cells was used to genotype four genetic polymorphisms: rs9340799 (A>G) and rs2234693 (C>T), located in ESR1; and rs1256049 (C>T) and rs4986938 (C>T), located in ESR2. A statistical analysis was performed and values of p<0.05 indicated statistical difference. Results: A total of 79 patients were included, 44 (55.70%) girls and 35 (44.30%) boys. The Demirjian, Goldstein, and Tanner method, in general, overestimated patients’ age by 0.75 years. There was no difference in the delta of dental age between the sexes (p>0.05). Genetic polymorphisms in ESR1 and ESR2 were not associated with dental age (p>0.05). Conclusion: The studied genetic polymorphisms in ESR1 and ESR2 were not associated with dental age in Brazilian childrenUniversidade de São Paulo. Faculdade de Odontologia de Bauru2023-10-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/21696710.1590/1678-7757-2023-0184 Journal of Applied Oral Science; Vol. 31 (2023); e20230184Journal of Applied Oral Science; v. 31 (2023); e20230184Journal of Applied Oral Science; Vol. 31 (2023); e202301841678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/216967/198523Copyright (c) 2023 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMadalena, Isabela RibeiroReis, Caio Luiz BitencourtMatsumoto, Mirian Aiko NakaneStuani, Maria Bernadete SassoMattos, Natanael Henrique RibeiroOliveira, Daniela Silva Barroso deOliveira, Maria Angélica Hueb de MenezesRoskamp, LilianeKüchler, Erika CalvanoBaratto-Filho, Flares 2024-02-07T17:41:05Zoai:revistas.usp.br:article/216967Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2024-02-07T17:41:05Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
title |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
spellingShingle |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors Madalena, Isabela Ribeiro Odontogenesis Estrogen Genes |
title_short |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
title_full |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
title_fullStr |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
title_full_unstemmed |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
title_sort |
Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors |
author |
Madalena, Isabela Ribeiro |
author_facet |
Madalena, Isabela Ribeiro Reis, Caio Luiz Bitencourt Matsumoto, Mirian Aiko Nakane Stuani, Maria Bernadete Sasso Mattos, Natanael Henrique Ribeiro Oliveira, Daniela Silva Barroso de Oliveira, Maria Angélica Hueb de Menezes Roskamp, Liliane Küchler, Erika Calvano Baratto-Filho, Flares |
author_role |
author |
author2 |
Reis, Caio Luiz Bitencourt Matsumoto, Mirian Aiko Nakane Stuani, Maria Bernadete Sasso Mattos, Natanael Henrique Ribeiro Oliveira, Daniela Silva Barroso de Oliveira, Maria Angélica Hueb de Menezes Roskamp, Liliane Küchler, Erika Calvano Baratto-Filho, Flares |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Madalena, Isabela Ribeiro Reis, Caio Luiz Bitencourt Matsumoto, Mirian Aiko Nakane Stuani, Maria Bernadete Sasso Mattos, Natanael Henrique Ribeiro Oliveira, Daniela Silva Barroso de Oliveira, Maria Angélica Hueb de Menezes Roskamp, Liliane Küchler, Erika Calvano Baratto-Filho, Flares |
dc.subject.por.fl_str_mv |
Odontogenesis Estrogen Genes |
topic |
Odontogenesis Estrogen Genes |
description |
Background: Genetic polymorphisms have been shown to influence several physiological traits, including dental and craniofacial characteristics. Understanding the clinical relevance of genetic polymorphisms in dental practice is crucial to personalize treatment plans and improve treatment outcomes. Objective: to evaluate the association between dental age and genetic polymorphisms in genes encoding estrogen receptors alpha and beta (ESR1 and ESR2, respectively) in a sample of Brazilian children. Methodology: This retrospective cross-sectional study was performed with children undergoing orthodontic treatment. Patients with syndromes, congenital anomalies, craniofacial deformities, under hormonal or systemic treatment, and with a previous history of facial trauma were excluded. Panoramic radiographs were used to assess dental age according to the Demirjian, Goldstein, and Tanner method. A delta [dental age-chronological age (DA-CA)] was obtained, which shows whether the patient tends to have a normal, delayed (negative values), or advanced (positive values) dental age. DNA isolated from buccal cells was used to genotype four genetic polymorphisms: rs9340799 (A>G) and rs2234693 (C>T), located in ESR1; and rs1256049 (C>T) and rs4986938 (C>T), located in ESR2. A statistical analysis was performed and values of p<0.05 indicated statistical difference. Results: A total of 79 patients were included, 44 (55.70%) girls and 35 (44.30%) boys. The Demirjian, Goldstein, and Tanner method, in general, overestimated patients’ age by 0.75 years. There was no difference in the delta of dental age between the sexes (p>0.05). Genetic polymorphisms in ESR1 and ESR2 were not associated with dental age (p>0.05). Conclusion: The studied genetic polymorphisms in ESR1 and ESR2 were not associated with dental age in Brazilian children |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/216967 10.1590/1678-7757-2023-0184 |
url |
https://www.revistas.usp.br/jaos/article/view/216967 |
identifier_str_mv |
10.1590/1678-7757-2023-0184 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/216967/198523 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 31 (2023); e20230184 Journal of Applied Oral Science; v. 31 (2023); e20230184 Journal of Applied Oral Science; Vol. 31 (2023); e20230184 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221670365986816 |