Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy

Detalhes bibliográficos
Autor(a) principal: Meca,Lívia Buzati
Data de Publicação: 2009
Outros Autores: Souza,Fátima Regina Nunes de, Tanimoto,Helio Massaioshi, Castro,Alvimar Lima de, Gaetti-Jardim Júnior,Elerson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572009000700003
Resumo: The aim of this study was to evaluate the influence of chlorhexidine gluconate, sodium fluoride and sodium iodine on mutans streptococci counts in saliva of irradiated patients. MATERIAL AND METHODS: Forty-five patients were separated into three experimental groups and received chlorhexidine (0.12%), sodium fluoride (0.5%) or sodium iodine (2%), which were used daily during radiotherapy and for 6 months after the conclusion of the treatment. In addition, a fourth group, composed by 15 additional oncologic patients, who did not receive the mouthwash or initial dental treatment, constituted the control group. Clinical evaluations were performed in the first visit to dental clinic, after initial dental treatment, immediately before radiotherapy, after radiotherapy and 30, 60, 90 days and 6 months after the conclusion of radiotherapy. After clinical examinations, samples of saliva were inoculated on SB20 selective agar and incubated under anaerobiosis, at 37ºC for 48 h. Total mutans streptococci counts were also evaluated by using real-time PCR, through TaqMan system, with specific primers and probes for S. mutans and S. sobrinus. RESULTS: All preventive protocols were able to reduce significantly mutans streptococci counts, but chlorhexidine gluconate was the most effective, and induced a significant amelioration of radiotherapy side effects, such as mucositis and candidosis. CONCLUSION: These results highlights the importance of the initial dental treatment for patients who will be subjected to radiotherapy for head and neck cancer treatment.
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spelling Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapyRadiotherapyStreptococcus mutansDental cariesThe aim of this study was to evaluate the influence of chlorhexidine gluconate, sodium fluoride and sodium iodine on mutans streptococci counts in saliva of irradiated patients. MATERIAL AND METHODS: Forty-five patients were separated into three experimental groups and received chlorhexidine (0.12%), sodium fluoride (0.5%) or sodium iodine (2%), which were used daily during radiotherapy and for 6 months after the conclusion of the treatment. In addition, a fourth group, composed by 15 additional oncologic patients, who did not receive the mouthwash or initial dental treatment, constituted the control group. Clinical evaluations were performed in the first visit to dental clinic, after initial dental treatment, immediately before radiotherapy, after radiotherapy and 30, 60, 90 days and 6 months after the conclusion of radiotherapy. After clinical examinations, samples of saliva were inoculated on SB20 selective agar and incubated under anaerobiosis, at 37ºC for 48 h. Total mutans streptococci counts were also evaluated by using real-time PCR, through TaqMan system, with specific primers and probes for S. mutans and S. sobrinus. RESULTS: All preventive protocols were able to reduce significantly mutans streptococci counts, but chlorhexidine gluconate was the most effective, and induced a significant amelioration of radiotherapy side effects, such as mucositis and candidosis. CONCLUSION: These results highlights the importance of the initial dental treatment for patients who will be subjected to radiotherapy for head and neck cancer treatment.Faculdade De Odontologia De Bauru - USP2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572009000700003Journal of Applied Oral Science v.17 n.spe 2009reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572009000700003info:eu-repo/semantics/openAccessMeca,Lívia BuzatiSouza,Fátima Regina Nunes deTanimoto,Helio MassaioshiCastro,Alvimar Lima deGaetti-Jardim Júnior,Elersoneng2011-03-04T00:00:00Zoai:scielo:S1678-77572009000700003Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2011-03-04T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
title Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
spellingShingle Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
Meca,Lívia Buzati
Radiotherapy
Streptococcus mutans
Dental caries
title_short Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
title_full Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
title_fullStr Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
title_full_unstemmed Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
title_sort Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy
author Meca,Lívia Buzati
author_facet Meca,Lívia Buzati
Souza,Fátima Regina Nunes de
Tanimoto,Helio Massaioshi
Castro,Alvimar Lima de
Gaetti-Jardim Júnior,Elerson
author_role author
author2 Souza,Fátima Regina Nunes de
Tanimoto,Helio Massaioshi
Castro,Alvimar Lima de
Gaetti-Jardim Júnior,Elerson
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Meca,Lívia Buzati
Souza,Fátima Regina Nunes de
Tanimoto,Helio Massaioshi
Castro,Alvimar Lima de
Gaetti-Jardim Júnior,Elerson
dc.subject.por.fl_str_mv Radiotherapy
Streptococcus mutans
Dental caries
topic Radiotherapy
Streptococcus mutans
Dental caries
description The aim of this study was to evaluate the influence of chlorhexidine gluconate, sodium fluoride and sodium iodine on mutans streptococci counts in saliva of irradiated patients. MATERIAL AND METHODS: Forty-five patients were separated into three experimental groups and received chlorhexidine (0.12%), sodium fluoride (0.5%) or sodium iodine (2%), which were used daily during radiotherapy and for 6 months after the conclusion of the treatment. In addition, a fourth group, composed by 15 additional oncologic patients, who did not receive the mouthwash or initial dental treatment, constituted the control group. Clinical evaluations were performed in the first visit to dental clinic, after initial dental treatment, immediately before radiotherapy, after radiotherapy and 30, 60, 90 days and 6 months after the conclusion of radiotherapy. After clinical examinations, samples of saliva were inoculated on SB20 selective agar and incubated under anaerobiosis, at 37ºC for 48 h. Total mutans streptococci counts were also evaluated by using real-time PCR, through TaqMan system, with specific primers and probes for S. mutans and S. sobrinus. RESULTS: All preventive protocols were able to reduce significantly mutans streptococci counts, but chlorhexidine gluconate was the most effective, and induced a significant amelioration of radiotherapy side effects, such as mucositis and candidosis. CONCLUSION: These results highlights the importance of the initial dental treatment for patients who will be subjected to radiotherapy for head and neck cancer treatment.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572009000700003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572009000700003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572009000700003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.17 n.spe 2009
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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