Diagnostic potential of Type VII Collagen during oral carcinogenesis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/212051 |
Resumo: | Type VII collagen (Col7) is a major component of anchoring fibrils. Col7 plays a role in tumor development and aggressiveness of cutaneous squamous cell carcinoma of recessive dystrophic epidermolysis bullosa. However, the role of Col7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL) remains largely unknown. Objective: To elucidate the role of Col7 and its diagnostic potential during oral carcinogenesis. Methodology: Col7 expression was immunohistochemically studied in 254 samples, including normal oral mucosa (NM), OL without dysplasia, OL with dysplasia, and OSCC. The correlation between Col7 expression and clinicopathologic parameters of OSCC was also determined. Results: Col7 was present as a linear deposit at the basement membrane of NM, OL without dysplasia and OL with dysplasia, and at the tumor-stromal junction around tumor islands in OSCC. Discontinuity of expression was frequently observed in OL with dysplasia and OSCC. OSCC had the significantly lowest Col7 expression (p<0.0001). Compared with OL without dysplasia, OL with dysplasia showed significantly reduced Col7 expression. Patients in clinical stage 4 with positive nodes had low Col7 expression compared with those in clinical stage 1 and negative nodes, respectively. Conclusion: Loss of Col7 is associated with tumorigenesis and aggressiveness in OSCC. A significantly reduced Col7 expression in OSCC implies that Col7 may be a useful marker for diagnosis and therapeutic targets. |
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Journal of applied oral science (Online) |
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Diagnostic potential of Type VII Collagen during oral carcinogenesisDysplasiaOral leukoplakiaOral potentially malignant disordersOral squamous cell carcinomaType VII collagenType VII collagen (Col7) is a major component of anchoring fibrils. Col7 plays a role in tumor development and aggressiveness of cutaneous squamous cell carcinoma of recessive dystrophic epidermolysis bullosa. However, the role of Col7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL) remains largely unknown. Objective: To elucidate the role of Col7 and its diagnostic potential during oral carcinogenesis. Methodology: Col7 expression was immunohistochemically studied in 254 samples, including normal oral mucosa (NM), OL without dysplasia, OL with dysplasia, and OSCC. The correlation between Col7 expression and clinicopathologic parameters of OSCC was also determined. Results: Col7 was present as a linear deposit at the basement membrane of NM, OL without dysplasia and OL with dysplasia, and at the tumor-stromal junction around tumor islands in OSCC. Discontinuity of expression was frequently observed in OL with dysplasia and OSCC. OSCC had the significantly lowest Col7 expression (p<0.0001). Compared with OL without dysplasia, OL with dysplasia showed significantly reduced Col7 expression. Patients in clinical stage 4 with positive nodes had low Col7 expression compared with those in clinical stage 1 and negative nodes, respectively. Conclusion: Loss of Col7 is associated with tumorigenesis and aggressiveness in OSCC. A significantly reduced Col7 expression in OSCC implies that Col7 may be a useful marker for diagnosis and therapeutic targets.Universidade de São Paulo. Faculdade de Odontologia de Bauru2023-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/21205110.1590/1678-7757-2022-0486Journal of Applied Oral Science; Vol. 31 (2023); e2022-0486Journal of Applied Oral Science; Vol. 31 (2023); e2022-0486Journal of Applied Oral Science; v. 31 (2023); e2022-04861678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/212051/194186Copyright (c) 2023 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPoomsawat, SopeeKariya, Abdulshukor Nimmanon, ThirayostJuengsomjit, RachaiSanguansin, Sirima 2023-05-15T20:07:23Zoai:revistas.usp.br:article/212051Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2023-05-15T20:07:23Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
title |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
spellingShingle |
Diagnostic potential of Type VII Collagen during oral carcinogenesis Poomsawat, Sopee Dysplasia Oral leukoplakia Oral potentially malignant disorders Oral squamous cell carcinoma Type VII collagen |
title_short |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
title_full |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
title_fullStr |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
title_full_unstemmed |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
title_sort |
Diagnostic potential of Type VII Collagen during oral carcinogenesis |
author |
Poomsawat, Sopee |
author_facet |
Poomsawat, Sopee Kariya, Abdulshukor Nimmanon, Thirayost Juengsomjit, Rachai Sanguansin, Sirima |
author_role |
author |
author2 |
Kariya, Abdulshukor Nimmanon, Thirayost Juengsomjit, Rachai Sanguansin, Sirima |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Poomsawat, Sopee Kariya, Abdulshukor Nimmanon, Thirayost Juengsomjit, Rachai Sanguansin, Sirima |
dc.subject.por.fl_str_mv |
Dysplasia Oral leukoplakia Oral potentially malignant disorders Oral squamous cell carcinoma Type VII collagen |
topic |
Dysplasia Oral leukoplakia Oral potentially malignant disorders Oral squamous cell carcinoma Type VII collagen |
description |
Type VII collagen (Col7) is a major component of anchoring fibrils. Col7 plays a role in tumor development and aggressiveness of cutaneous squamous cell carcinoma of recessive dystrophic epidermolysis bullosa. However, the role of Col7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL) remains largely unknown. Objective: To elucidate the role of Col7 and its diagnostic potential during oral carcinogenesis. Methodology: Col7 expression was immunohistochemically studied in 254 samples, including normal oral mucosa (NM), OL without dysplasia, OL with dysplasia, and OSCC. The correlation between Col7 expression and clinicopathologic parameters of OSCC was also determined. Results: Col7 was present as a linear deposit at the basement membrane of NM, OL without dysplasia and OL with dysplasia, and at the tumor-stromal junction around tumor islands in OSCC. Discontinuity of expression was frequently observed in OL with dysplasia and OSCC. OSCC had the significantly lowest Col7 expression (p<0.0001). Compared with OL without dysplasia, OL with dysplasia showed significantly reduced Col7 expression. Patients in clinical stage 4 with positive nodes had low Col7 expression compared with those in clinical stage 1 and negative nodes, respectively. Conclusion: Loss of Col7 is associated with tumorigenesis and aggressiveness in OSCC. A significantly reduced Col7 expression in OSCC implies that Col7 may be a useful marker for diagnosis and therapeutic targets. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/212051 10.1590/1678-7757-2022-0486 |
url |
https://www.revistas.usp.br/jaos/article/view/212051 |
identifier_str_mv |
10.1590/1678-7757-2022-0486 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/212051/194186 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 31 (2023); e2022-0486 Journal of Applied Oral Science; Vol. 31 (2023); e2022-0486 Journal of Applied Oral Science; v. 31 (2023); e2022-0486 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221683563364352 |